Effects of acute intravenous administration of pentamidine, a typical hERG-trafficking inhibitor, on the cardiac repolarization process of halothane-anesthetized dogs

Journal of Pharmacological Sciences

Volumn 110, Issue 4, 2009, Pages 476-482

  Yokoyama, Hirofumi ^a,b   Nakamura, Yuji ^a   Iwasaki, Hiroshi ^a   Nagayama, Yukitoshi ^a,b,c   Hoshiai, Kiyotaka ^a,b,c   Mitsumori, Yoshitaka ^a   Sugiyama, Atsushi ^a,b  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b Yamanashi Research Center of Clinical Pharmacology   (Japan)

^c Sugi Institute of Biological Science   (Japan)

Author keywords

Monophasic action potential; Pentamidine; QT prolongation; Torsades de pointes; Trafficking

Indexed keywords

BENAMBAX; HALOTHANE; PENTAMIDINE; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; BLOOD VESSEL TONE; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; FEMALE; HEART FUNCTION; HEART PRELOAD; HEART REPOLARIZATION; HEART VENTRICLE CONTRACTION; HEMODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; REPOLARIZATION; SYMPATHETIC TONE; VASCULAR RESISTANCE;

ANESTHETICS, INHALATION; ANIMALS; ANTIPROTOZOAL AGENTS; BLOOD PRESSURE; DOGS; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HALOTHANE; INFUSIONS, INTRAVENOUS; MALE; MYOCARDIAL CONTRACTION; PENTAMIDINE; PROTEIN TRANSPORT;

EID: 68849086657     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.09071FP     Document Type: Article

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