In vitro interaction between suramin and fluvastatin against clinically important Zygomycetes

Mycoses

Volumn 52, Issue 5, 2009, Pages 447-453

  Galgóczy, László ^a   Papp, Tamás ^a   Vágvölgyi, Csaba ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Drug interaction; Fluvastatin; Suramin; Zygomycetes

Indexed keywords

FLUINDOSTATIN; SURAMIN;

ABSIDIA; ANTIFUNGAL ACTIVITY; ARTICLE; DRUG ANTAGONISM; DRUG POTENTIATION; FUNGAL STRAIN; FUNGUS ISOLATION; GROWTH INHIBITION; HUMAN; IN VITRO STUDY; MORTIERELLA; MUCOR; NONHUMAN; PRIORITY JOURNAL; RHIZOMUCOR; RHIZOPUS; SAKSENAEA; SYNCEPHALASTRUM; ZYGOMYCETES;

ANIMALS; ANTIFUNGAL AGENTS; DRUG INTERACTIONS; FATTY ACIDS, MONOUNSATURATED; FUNGI; HUMANS; INDOLES; MICROBIAL SENSITIVITY TESTS; SURAMIN;

ABSIDIA; ANIMALIA; MICROMUCOR; MORTIERELLA; MUCOR; RHIZOMUCOR; RHIZOPUS; SAKSENAEA; SYNCEPHALASTRUM; ZYGOMYCETES;

EID: 68749118713     PISSN: 09337407     EISSN: 14390507     Source Type: Journal    
DOI: 10.1111/j.1439-0507.2008.01634.x     Document Type: Article

References (29)

1. Ribes JA, Vanhover-Sams CL, Baker DJ. Zygomycetes in human disease. Clin Microbiol Rev 2000 13 : 236 301.
2. Vazquez JA. Combination antifungal therapy: the new frontier. Future Microbiol 2007 2 : 115 39.
3. Gallagher CG, Ashley ESD, Drew RH, Perfect JR. Antifungal pharmacotherapy for invasive mould infections. Expert Opin Pharmacother 2003 4 : 147 64.
4. Vicente MF, Basilio A, Cabello A, Pelaez F. Microbial natural products as a source of antifungals. Clin Microbiol Infect 2003 9 : 15 32.
5. Kontoyiannis DP. Decrease in the number of reported cases of zygomycosis among patients with diabetes mellitus: a hypothesis. Clin Infect Dis 2007 44 : 1089 90.
6. Liao JK, Laufs U. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 2005 45 : 89 118.
7. Roze LV, Linz JE. Lovastatin triggers an apoptosis-like cell death process in the fungus Mucor racemosus. Fungal Genet Biol 1998 25 : 119 33.
8. Lukács Gy, Papp T, Nyilasi I, Nagy E, Vágvölgyi Cs. Differentiation of Rhizomucor species on the basis of their different sensitivities to lovastatin. J Clin Microbiol 2004 42 : 5400 2.
9. Chamilos G, Lewis RE, Kontoyiannis DP. Lovastatin has significant activity against Zygomycetes and interacts synergistically with voriconazole. Antimicrob Agents Chemother 2006 50 : 96 103.
10. Galgóczy L, Papp T, Lukács Gy, Leiter É, Pócsi I, Vágvölgyi Cs. Interactions between statins and Penicillium chrysogenum antifungal protein (PAF) to inhibit the germination of sporangiospores of different sensitive Zygomycetes. FEMS Microbiol Lett 2007 270 : 109 15.
11. Liao JK. Isoprenoids as mediators of the biological effects of statins. J Clin Invest 2002 110 : 285 8.
12. Westermann AM, Dubbelman R, Moolenaar WH, Beijnen J, Rodenhuis S. Successful intraperitoneal suramin treatment of peritoneal mesothelioma. Ann Oncol 1997 8 : 801 2.
13. Villalona-Calero MA, Wientjes MG, Otterson GA et al. Phase I study of low-dose suramin as a chemosensitizer in patients with advanced non-small cell lung cancer. Clin Cancer Res 2003 9 : 3303 11.
14. National Committee for Clinical Laboratory Standards. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi; Approved Standard. NCCLS document M38-A. NCCLS, Wayne, Pennsylvania, USA : NCCLS, 2002.
15. Rodriguez-Tudela JL, Arendrup MC, Arikan S et al. Method for the Determination of Broth Dilution Minimum Inhibitory Concentrations of Antifungal Agents for Conidia Forming Moulds. EUCAST Discussion Document, Basel, Switzerland : European Society of Clinical Microbiology and Infectious Disease, 2007. Available at http://www.escmid.org/sites/index-f.aspx?par=2.4.
16. Meletiadis J, te Dorsthorst DA, Verweij PE. The concentration-dependent nature of in vitro amphotericin B-itraconazole interaction against Aspergillus fumigatus: isobolographic and response surface analysis of complex pharmacodynamic interactions. Int J Antimicrob Agents 2006 28 : 439 49.
17. Moreno AB, del Pozo AM, Borja M, San Segudo B. Activity of the antifungal protein from Aspergillus giganteus against Botrytis cinerea. Phytopathology 2003 93 : 1344 53.
18. Afeltra J, Verweij PE. Antifungal activity of nonantifungal drugs. Eur J Clin Microbiol Infect Dis 2003 22 : 397 407.
19. Ghittoni R, Patrussi L, Pirozzi K et al. Simvastatin inhibits T cell activation by selectively impairing the function of Ras superfamily GTPases. FASEB J 2005 19 : 605 7. online article.
20. Cordle A, Koenigsknecht-Talboo J, Wilkinson B, Limpert A, Landreth G. Mechanism of statin-mediated inhibition of small G-protein function. J Biol Chem 2005 280 : 34202 9.
21. Miida T, Hirayama S, Nakamura Y. Cholesterol-independent effects of statins and new therapeutic strategies: ischemic stroke and dementia. J Atheroscler Thromb 2004 11 : 253 64.
22. Braga-Silva LA, Souza dos Santos AL, Portela MB, Souto-Padrón T, de AraújoSoaresRM. Effect of suramin on the human pathogen Candida albicans: implications on the fungal development and virulence. FEMS Immunol Med Microbiol 2007 51 : 399 406.
23. Hussain M, Fisher EI, Petrylak DP et al. Androgen deprivation and four courses of fixed-schedule suramin treatment in patients with newly diagnosed metastatic prostate Cancer: a southwest oncology group study. J Clin Oncol 2000 18 : 1043 9.
24. Gschwendta M, Kittsteina W, Johannesb F-J. Differential effects of suramin on protein kinase C isoenzymes. A novel tool for discriminating protein kinase C activities. FEBS Lett 1998 421 : 165 8.
25. Shea JM, Del Poeta M. Lipid signaling in pathogenic fungi. Curr Opin Microbiol 2006 9 : 352 8.
26. Herrmann M, Spröte P, Brakhage AA. Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production. Appl Environ Microbiol 2006 72 : 2957 70.
27. Herman RJ. Drug interactions and the statins. Can Med Assoc J 1999 161 : 1281 6.
28. Chan KKW, Oza AM, Siu LL. The statins as anticancer agents. Clin Cancer Res 2003 9 : 10 19.
29. Bapiro TE, Egnell A-C, Hasler JA, Masimirembwa CM. Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450S. Drug Metab Dispos 2001 29 : 30 35.