Intercoat Gel (Oxiplex): Efficacy, Safety, and Tissue Response in a Laparoscopic Mouse Model

Journal of Minimally Invasive Gynecology

Volumn 16, Issue 2, 2009, Pages 188-194

  Schonman, Ron ^a,b   Corona, Roberta ^a   Bastidas, Adriana ^a   De Cicco, Carlo ^a   Mailova, Karina ^a   Koninckx, Philippe Robert ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

Adhesion formation; Animal Model; Intercoat; Laparoscopy; Oxiplex

Indexed keywords

CD45 ANTIGEN; EOSIN; HEMATOXYLIN;

ADHESION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EDEMA; FEMALE; GEL; HISTOLOGY; INFLAMMATION; LAPAROSCOPIC SURGERY; MICROSCOPY; MORPHOLOGY; MOUSE; NONHUMAN; PNEUMOPERITONEUM; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SAFETY; TISSUE REACTION; VASODILATATION;

ANIMALS; CELLULOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GELS; LAPAROSCOPY; MICE; MICE, INBRED BALB C; OMENTUM; PNEUMOPERITONEUM, ARTIFICIAL; POLYETHYLENE GLYCOLS; PROTECTIVE AGENTS; TISSUE ADHESIONS; WOUND HEALING;

EID: 68749099603     PISSN: 15534650     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmig.2008.12.014     Document Type: Article

References (38)

1. DeCherney A.H., and diZerega G.S. Clinical problem of intraperitoneal post surgical adhesion formation following general surgery and the use of adhesion prevention barriers. Surg Clin North Am 77 (1997) 671-688
2. Kutlay J., Ozer Y., Isik B., and Kargici H. Comparative effectiveness of several agents for preventing postoperative adhesions. World J Surg 28 (2004) 662-665
3. Ustun C., Kocak I., and Akpolat I. Effects of Seprafilm (sodium hyaluranate-based bioresorbable), Sepracoat (0.4% hyaluronic acid), and Ringer's lactate on the prevention of postsurgical adhesion formation in rat models. J Obstet Gynaecol 20 (2000) 78-80
4. Eroglu A., Demirci S., Kurtman C., Akbay A., and Eroglu N. Prevention of intra-abdominal adhesions by using Seprafilm in rats undergoing bowel resection and radiation therapy. Colorectal Dis 3 (2000) 33-37
5. Vrijland W.W., Tseng L.N., Eijkman H.J., et al. Fewer intraperitoneal adhesions with use of hyaluronic acid-carboxymethylcellulose membrane: a randomized clinical trial. Ann Surg 235 (2002) 193-199
6. Wallwiener M., Brucker S., Hierlemann H., Brochhausen C., Solomayer E., and Wallwiener C. Innovative barriers for peritoneal adhesion prevention: liquid or solid? A rat uterine horn model. Fertil Steril 86 (2006) 1266-1276
7. Nordic Adhesion Prevention Study Group. The efficacy of Interceed (TC7)* for prevention of reformation of postoperative adhesions on ovaries, fallopian tubes, and fimbriae in microsurgical operations for fertility: a multicenter study. Fertil Steril 63 (1995) 709-714
8. INTERCEED(TC7) Adhesion Barrier Study Group. Prevention of postsurgical adhesions by INTERCEED(TC7), an absorbable adhesion barrier: a prospective randomized multicenter clinical study. Fertil Steril 51 (1989) 933-938
9. Dunn R., Lyman M.D., Edelman P.G., and Campbell P.K. Evaluation of the SprayGel adhesion barrier in the rat cecum abrasion and rabbit uterine horn adhesion models. Fertil Steril 75 (2001) 411-416
10. Ferland R., Mulani D., and Campbell P.K. Evaluation of a sprayable polyethylene glycol adhesion barrier in a porcine efficacy model. Hum Reprod 16 (2001) 2718-2723
11. Johns D.A., Ferland R., and Dunn R. Initial feasibility study of a sprayable hydrogel adhesion barrier system in patients undergoing laparoscopic ovarian surgery. J Am Assoc Gynecol Laparosc 10 (2003) 334-338
12. Mettler L., Audebert A., Lehmann-Willenbrock E., Schive K., and Jacobs V.R. Prospective clinical trial of SprayGel as a barrier to adhesion formation: an interim analysis. J Am Assoc Gynecol Laparosc 10 (2003) 339-344
13. Mettler L., Audebert A., Lehmann-Willenbrock E., Schive-Peterhansl K., and Jacobs V.R. A randomized, prospective, controlled, multicenter clinical trial of a sprayable, site-specific adhesion barrier system in patients undergoing myomectomy. Fertil Steril 82 (2004) 398-404
14. De Iaco P.A., Stefanetti M., Pressato D., et al. A novel hyaluronan-based gel in laparoscopic adhesion prevention: preclinical evaluation in an animal model. Fertil Steril 69 (1998) 318-323
15. De Iaco P.A., Muzzupapa G., Bigon E., et al. Efficacy of a hyaluronan derivative gel in postsurgical adhesion prevention in the presence of inadequate hemostasis. Surgery 130 (2001) 60-64
16. Belluco C., Meggiolaro F., Pressato D., et al. Prevention of postsurgical adhesions with an autocrosslinked hyaluronan derivative gel. J Surg Res 100 (2001) 217-221
17. Kocak I., Unlu C., Akcan Y., and Yakin K. Reduction of adhesion formation with cross-linked hyaluronic acid after peritoneal surgery in rats. Fertil Steril 72 (1999) 873-878
18. Pellicano M., Bramante S., Cirillo D., et al. Effectiveness of autocrosslinked hyaluronic acid gel after laparoscopic myomectomy in infertile patients: a prospective, randomized, controlled study. Fertil Steril 80 (2003) 441-444
19. Pellicano M., Guida M., Bramante S., et al. Reproductive outcome after autocrosslinked hyaluronic acid gel application in infertile patients who underwent laparoscopic myomectomy. Fertil Steril 83 (2005) 498-500
20. Acunzo G., Guida M., Pellicano M., et al. Effectiveness of auto-cross-linked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic adhesiolysis: a prospective, randomized, controlled study. Hum Reprod 18 (2003) 1918-1921
21. Guida M., Acunzo G., Di Spiezio S.A., et al. Effectiveness of auto-crosslinked hyaluronic acid gel in the prevention of intrauterine adhesions after hysteroscopic surgery: a prospective, randomized, controlled study. Hum Reprod 19 (2004) 1461-1464
22. Rodgers K.E., Schwartz H.E., Roda N., Thornton M., Kobak W., and diZerega G.S. Effect of Oxiplex* films (PEO/CMC) on adhesion formation and reformation in rabbit models and on peritoneal infection in a rat model. Fertil Steril 73 (2000) 831-838
23. Rodgers K.E., Robertson J.T., Espinoza T., et al. Reduction of epidural fibrosis in lumbar surgery with Oxiplex adhesion barriers of carboxymethylcellulose and polyethylene oxide. Spine J 3 (2003) 277-283
24. Kim K.D., Wang J.C., Robertson D.P., et al. Reduction of radiculopathy and pain with Oxiplex/SP gel after laminectomy, laminotomy, and discectomy: a pilot clinical study. Spine 28 (2003) 1080-1087
25. Lundorff P., Donnez J., Korell M., Audebert A.J., Block K., and diZerega G.S. Clinical evaluation of a viscoelastic gel for reduction of adhesions following gynecological surgery by laparoscopy in Europe. Hum Reprod 20 (2005) 514-520
26. diZerega G.S., Coad J., and Donnez J. Clinical evaluation of endometriosis and differential response to surgical therapy with and without application of Oxiplex/AP* adhesion barrier gel. Fertil Steril 87 (2007) 485-489
27. Molinas C.R., Mynbaev O., Pauwels A., Novak P., and Koninckx P.R. Peritoneal mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation in a laparoscopic mouse model. Fertil Steril 76 (2001) 560-567
28. Binda M.M., Molinas C.R., Mailova K., and Koninckx P.R. Effect of temperature upon adhesion formation in a laparoscopic mouse model. Hum Reprod 19 (2004) 2626-2632
29. Elkelani O.A., Binda M.M., Molinas C.R., and Koninckx P.R. Effect of adding more than 3% of oxygen to carbon dioxide pneumoperitoneum upon adhesion formation in a laparoscopic mouse model. Fertil Steril 82 (2004) 1616-1622
30. Molinas C.R., Campo R., Elkelani O.A., Binda M.M., Carmeliet P., and Koninckx P.R. Role of hypoxia inducible factors 1alpha and 2alpha in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 80 (2003) 795-802
31. Binda M.M., Molinas C.R., Hansen P., and Koninckx P.R. Effect of desiccation and temperature during laparoscopy on adhesion formation in mice. Fertil Steril 86 (2006) 166-175
32. Molinas C.R., Campo R., Dewerchin M., Eriksson U., Carmeliet P., and Koninckx P.R. Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 80 (2003) 803-811
33. Molinas C.R., Elkelani O., Campo R., Luttun A., Carmeliet P., and Koninckx P.R. Role of the plasminogen system in basal adhesion formation and carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril 80 (2003) 184-192
34. Elkelani O.A., Molinas C.R., Mynbaev O., and Koninckx P.R. Prevention of adhesions with crystalloids during laparoscopic surgery in mice. J Am Assoc Gynecol Laparosc 9 (2002) 447-452
35. Molinas C.R., Binda M.M., Campo R., and Koninckx P.R. Adhesion formation and interanimal variability in a laparoscopic mouse model varies with strains. Fertil Steril 83 (2005) 1871-1874
36. 2 on the dissipation of residual gas following laparoscopy in piglets. J Am Assoc Gynecol Laparosc 11 (2004) 204-210
37. diZerega G.S., Cortese S., Rodgers K.E., et al. A modern biomaterial for adhesion prevention. J Biomed Mater Res B Appl Biomater 81 (2007) 239-250
38. Nagelschmidt M., Minor T., and Saad S. Polyethylene glycol 4000 attenuates adhesion formation in rats by suppression of peritoneal inflammation and collagen incorporation. Am J Surg 176 (1998) 76-80