Polyethylene glycol 4000 attenuates adhesion formation in rats by suppression of peritoneal inflammation and collagen incorporation

American Journal of Surgery

Volumn 176, Issue 1, 1998, Pages 76-80

  Nagelschmidt, Manfred ^a   Minor, Thomas ^a   Saad, Stefan ^a   Nagelschmidt II, Manfred ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL 400;

ABDOMINAL SURGERY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PERITONEUM ADHESION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RAT;

ADHESIONS; ADMINISTRATION, TOPICAL; ANIMALS; COLLAGEN; EXCIPIENTS; FOLLOW-UP STUDIES; LEUKOCYTE COUNT; LEUKOCYTES; MALE; PERITONEUM; PERITONITIS; POLYETHYLENE GLYCOLS; POSTOPERATIVE COMPLICATIONS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME;

EID: 0032127150     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9610(98)00102-0     Document Type: Article

References (25)

1. Menzies D., Ellis H. Intestinal obstruction from adhesions. How big is the problem? Ann R Coll Surg Engl. 72:1990;60-63.
2. Ellis H. Internal overhealing the problem of intraperitoneal adhesions . World J Surg. 4:1980;303-306.
3. Goldberg E.P., Burns J.W., Yaacobi Y. Prevention of postoperative adhesions by precoating tissues with dilute sodium hyaluronate solutions. Prog Clin Biol Res. 381:1993;191-204.
4. Kalitala E.H., Lenkkeri H., Larmi J.K. Mechanical intestinal obstruction. An analysis of 577 cases. Ann Chir Gynecol. 61:1972;87-90.
5. Leffall S.D., Syphax B. Clinical aids in strangulated intestinal obstruction. Am J Surg. 120:1970;756-758.
6. Ray N.F., Larsen J.W., Stillman R.J. Jr, Jacobs R.J. Economic impact of hospitalizations for lower abdominal adhesioloysis in the United States in 1988. Surg Gynecol Obstet. 176:1993;271-276.
7. Holtz G. Prevention and management of peritoneal adhesions. Fertil Steril. 41:1984;497-507.
8. Buckman R.F., Woods M., Sargent L., Gervin A.S. A unifying pathogenic mechanism in the etiology of intraperitoneal adhesions. J Surg Res. 20:1976;1-5.
9. Holtz G. Overview of classical adjuvant approaches gynecologic surgery and adhesion prevention . Prog Clin Biol Res. 381:1993;81-95.
10. Pfeffer W.H. Adjuvants in tubal surgery. Fertil Steril. 33:1980;245-256.
11. Soules M.R., Dennis L., Bosarge A., Moore D.E. The prevention of postoperative pelvic adhesions an animal study comparing barrier methods with dextran 70 . Am J Obstet Gynecol. 143:1982;829-834.
12. Prevention of postsurgical adhesions by INTERCEED (TC7), an absorbable adhesion barrier: a prospective, randomized multicenter clinical study. Fertil Steril. 51:1989;933-938.
13. Beck D.E. The role of Seprafilm™ bioresorbable membrane in adhesion prevention. Eur J Surg. 163:(suppl 577):1997;49-55.
14. Ryan C.K., Sax H.C. Evaluation of a carboxymethylcellulose sponge for prevention of postoperative adhesions. Am J Surg. 169:1995;154-160.
15. Punnonen R., Viinamäki O. Polyethylene glycol 4000 in the prevention of peritoneal adhesions. Fertil Steril. 38:1982;491-492.
16. O'Sullivan D., O'Riordain M., O'Connell R.P., et al. Peritoneal adhesion formation after lysis inhibition by polyethylene glycol 4000 . Br J Surg. 78:1991;427-429.
17. Nagelschmidt M., Saad S. Influence of polyethylene glycol 400 and dextran 70 on adhesion formation in rats. J Surg Res. 67:1997;113-118.
18. Swolin K. Experimentelle Studien zur Prophylaxe von intraabdominalen Verwachsungen. Acta Obstet Gynecol Scand. 45:1966;473-498.
19. Knightly J.J., Agostino D., Cliffton E.E. The effect of fibrinolysin and heparin on the formation of peritoneal adhesions. Surgery. 52:1962;250-258.
20. Arakawa T., Timasheff S.N. Mechanism of poly(ethylene glycol) interaction with proteins. Biochemistry. 24:1985;6756-6762.
21. Mayer M., Yedgar S., Hurwitz A. Effect of viscous macromolecules on plasminogen activator activity. A potential mechanism for their ability to reduce postoperative adhesion formation. Am J Obstet Gynecol. 159:1988;957-963.
22. Hao YL, Wickerhauser M. An integrated plasma fractionation system based on use of polyethylene glycol. In: Sandberg HE, ed. Proceedings of the International Workshop on Technology for Protein Separation and Improvement of Blood Plasma Fractionation. Bethesda, Md: National Institutes of Health; 1977:372-379.
23. diZerega G.S. Biochemical events in peritoneal tissue repair. Eur J Surg. 163:(suppl 577):1997;10-16.
24. Montz F.J., Fowler J.M., Wolff A.J., et al. The ability of recombinant tissue plasminogen activator to inhibit post-radical pelvic surgery adhesions in the dog model. Am J Obstet Gynecol. 165:1991;1539-1542.
25. Holmdahl L., Al-Jabreen M., Risberg B. The role of fibrinolysis in the formation of postoperative adhesions. Wound Rep Reg. 2:1994;171-176.