Production of human β-hexosaminidase A with highly phosphorylated N-glycans by the overexpression of the Ogataea minuta MNN4 gene

Glycobiology

Volumn 19, Issue 9, 2009, Pages 1002-1009

  Akeboshi, Hiromi ^a,b   Kasahara, Yoshiko ^a,b   Tsuji, Daisuke ^b,c   Itoh, Kohji ^b,c   Sakuraba, Hitoshi ^b,d   Chiba, Yasunori ^a,b   Jigami, Yoshifumi ^a,b  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

hexosaminidase A; Enzyme replacement therapy; GM2 gangliosidosis; Methylotrophic yeast; MNN4

Indexed keywords

4 METHYLUMBERLLIFERYL N ACETYL BETA DEXTRO GLUCOSAMINIDE; ALCOHOL OXIDASE; BETA N ACETYLHEXOSAMINIDASE A; GANGLIOSIDE GM2; GLUCOSAMINE; GLYCAN; MANNOSYLTRANSFERASE; MANNOSYLTRANSFERASE 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GENE OVEREXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; LIPID DEGRADATION; MOLECULAR CLONING; MOUSE; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OGATAEA MINUTA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRUCTURE ANALYSIS; YEAST;

AMINO ACID SEQUENCE; BETA-N-ACETYLHEXOSAMINIDASES; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; POLYSACCHARIDES; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID;

PICHIA MINUTA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 68749097166     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwp080     Document Type: Article

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