Elevated levels of IL-1β in Fanconi anaemia group A patients due to a constitutively active phosphoinositide 3-kinase-Akt pathway are capable of promoting tumour cell proliferation

Biochemical Journal

Volumn 422, Issue 1, 2009, Pages 161-170

  Ibáñez, Ana ^a   Río, Paula ^b   Casado, José Antonio ^b   Bueren, Juan Antonio ^b   Fernández Luna, José Luis ^a   Pipaón, Carlos ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b CIEMAT   (Spain)

Author keywords

catenin; Akt; Fanconi anaemia (FA); Glycogen synthase kinase 3 (GSK3 ); Interleukin 1 (IL 1 ); Nuclear factor B (NF B)

Indexed keywords

AKT; BONE MARROW; CELL CYCLE; CONGENITAL MALFORMATIONS; CONSTITUTIVELY ACTIVES; ELEVATED LEVEL; FANCONI ANAEMIA (FA); GLIOBLASTOMAS; GLYCOGEN SYNTHASE KINASE-3; INTERLEUKIN-1; NUCLEAR FACTORS; OVER-EXPRESSION; PHOSPHOINOSITIDE 3-KINASE; PROGENITOR CELL; PROINFLAMMATORY CYTOKINES; TUMOUR CELLS; WILD TYPES;

CELL PROLIFERATION; ENZYMES; TRANSCRIPTION FACTORS; TUMORS;

CELL MEMBRANES;

COMPLEMENTARY DNA; FANCONI ANEMIA GROUP A PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ARTICLE; BLOOD SAMPLING; CANCER STEM CELL; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FANCONI ANEMIA; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; LYMPHOBLAST; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR GROWTH;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL PROLIFERATION; ENZYME ACTIVATION; FANCONI ANEMIA; FANCONI ANEMIA COMPLEMENTATION GROUP A PROTEIN; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTERLEUKIN-1BETA; LYMPHOCYTES; MUTATION; NEOPLASMS; NF-KAPPA B; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 68749092964     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20082118     Document Type: Article

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