Effect on the nasal bioavailability of co-processing drug and bioadhesive carrier via spray-drying

International Journal of Pharmaceutics

Volumn 379, Issue 1-2, 2009, Pages 67-71

  Coucke, D ^a   Vervaet, C ^a   Foreman, P ^b   Adriaensens, P ^c   Carleer, R ^c   Remon, J P ^a  

^a GHENT UNIVERSITY   (Belgium)

^b NATIONAL STARCH AND CHEMICAL COMPANY   (United States)

^c HASSELT UNIVERSITY   (Belgium)

Author keywords

Amioca Carbopol 974P powder formulation; Co spray drying as all in one process; Metoprolol tartrate; Nasal administration

Indexed keywords

AMYLOPECTIN; CARBOMER; METOPROLOL TARTRATE; POLYACRYLIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRY POWDER; FREEZE DRYING; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPRAY DRYING;

ACRYLATES; ADHESIVENESS; ADMINISTRATION, INTRANASAL; AMYLOPECTIN; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; FREEZE DRYING; METOPROLOL; POWDERS; RABBITS;

EID: 68649123770     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.06.008     Document Type: Article

References (17)

1. ® 974P mixtures as buccal bioadhesive carriers. Int. J. Pharm. 301 (2005) 170-180
2. ® 974P mixtures for the nasal delivery of insulin in rabbits. J. Control. Release 66 (2000) 215-220
3. Chang S.F., and Chien Y.W. Intranasal drug administration for systemic medication. Pharm. Int. 5 (1984) 287-288
4. Chien Y.W., and Chang Y. Historical developments of transnasal systemic medications. In: Chien Y.W. (Ed). Transnasal Systemic Medications: Fundamentals, Developmental Concepts and Biomedical Assessments (1985), Elsevier, Amsterdam, The Netherlands 1-100
5. Coucke D., Schotsaert M., Libert C., Pringels E., Vervaet C., Foreman P., Saelens X., and Remon J.P. Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine. Vaccine 27 (2009) 1279-1286
6. ® 974P used as carriers for nasal drug delivery, Int. J. Pharm., doi:10.1016/j.ijpharm.2009.05.041.
7. Frishman W.H., and Alwarshetty M. β-Adrenergic blockers in systemic hypertension. pharmacokinetic considerations related to the current guidelines. Clin. Pharmacokin. 41 (2002) 505-516
8. Garmise R.J., Mar K., Crowder T.M., Hwang C.R., Ferriter M., Huang J., Mikszta J.A., Sullivan V.J., and Hickey A.J. Formulation of a dry powder influenza vaccine for nasal delivery. AAPS Pharm. Sci. Tech. 7 (2006) 19
9. Gonnissen Y., Verhoeven E., Peeters E., Remon J.P., and Vervaet C. Coprocessing via spray drying as a formulation platform to improve the compactibility of various drugs. Eur. J. Pharm. Biopharm. 69 (2008) 320-334
10. Hinchcliffe M., and Illum L. Intranasal insulin delivery and therapy. Adv. Drug Del. Rev. 35 (1999) 199-234
11. Hinds W.C. Aerosol Technology: Properties, Behaviour and Measurement of Airborne Particles (1999), John Wiley, New York, NY
12. Kilian N., and Müller D.G. The effect of a viscosity and an absorption enhancer on the intra nasal absorption of metoprolol in rats. Int. J. Pharm. 163 (1998) 211-217
13. Pringels, E., 2005. Nasal delivery of peptides using powder carriers based on starch/poly(acrylic acid). Doctoral thesis, Ghent University, Belgium.
14. Rajinikanth P.S., Sankar C., and Mishra B. Sodium alginate microspheres of metoprolol tartrate for intranasal systemic delivery: development and evaluation. Drug Del. 1 (2003) 21-28
15. Sørensen, A., 1991. Animal models for buccal and nasal delivery studies, in: Duchêne, D. (Ed.), Buccal and Nasal Administration as an Alternative to Parenteral Administration, European Symposium, Paris, 10-11 December, Editions de Santé, pp. 162-173.
16. Teshima D., Yamauchi A., Makino K., Kataoka Y., Arita Y., Nawata H., and Oishi R. Nasal glucagon delivery using microcrystalline cellulose in healthy volunteers. Int. J. Pharm. 233 (2002) 61-66
17. Ugwoke M.I., Agu R.U., Verbeke N., and Kinget R. Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives. Adv. Drug Del. Rev. 57 (2005) 1640-1665