Coprocessing via spray drying as a formulation platform to improve the compactability of various drugs

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 69, Issue 1, 2008, Pages 320-334

  Gonnissen, Y ^a   Verhoeven, E ^a   Peeters, E ^a   Remon, J P ^a   Vervaet, C ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Acetaminophen; Carbohydrates; Cimetidine; Co spray drying; Compression; Continuous processing; Ibuprofen; Scaling up

Indexed keywords

AEROSIL; CARBOHYDRATE; CIMETIDINE; CROSPOVIDONE; DISINTEGRATING AGENT; ERIDEX; ERYTHRITOL; GLIDING AGENT; GLUCIDEX; IBUPROFEN; MALTODEXTRIN; MANNIDEX; MANNITOL; PARACETAMOL; POLYSORBATE 80; POVIDONE; SILICON DIOXIDE; SURFACTANT; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; DRUG FORMULATION; DRUG MANUFACTURE; EXPERIMENTAL DESIGN; POWDER; PROCESS DEVELOPMENT; REPRODUCIBILITY; SCALE UP; SOLID; SPRAY DRYING; SUSPENSION; TABLET COMPRESSION; TABLET FORMULATION;

ACETAMINOPHEN; CARBOHYDRATES; CHEMISTRY, PHARMACEUTICAL; CIMETIDINE; DESICCATION; DOSAGE FORMS; DRUG COMPOUNDING; IBUPROFEN; MICROSCOPY, ELECTRON, SCANNING; MODELS, STATISTICAL; PARTICLE SIZE; POVIDONE; POWDERS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; X-RAY DIFFRACTION;

EID: 41549113408     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.11.009     Document Type: Article

References (12)

1. Gohel M.C. A review of co-processed directly compressible excipients. J. Pharm. Pharm. Sci. 8 1 (2005) 76-93
2. Gohel M.C., and Jogani P.D. Exploration of melt granulation technique for the development of coprocessed directly compressible adjuvant containing lactose and microcrystalline cellulose. Pharm. Dev. Technol. 8 2 (2003) 175-185
3. Gonnissen Y., Remon J.P., and Vervaet C. Development of directly compressible powders via co-spray drying. Eur. J. Pharm. Biopharm. 67 (2007) 220-226
4. Y.Gonnissen, S.I.V. Gonçalves, J.P. Remon, C. Vervaet, Mixture design applied to optimise a directly compressible powder produced via co-spray drying, Drug Dev. Ind. Pharm., in press.
5. Y.Gonnissen, Remon J.P., and Vervaet C. Maltodextrin and superdisintegrant evaluation in coprocessed directly compressible powder mixtures. Eur. J. Pharm. Biopharm. 68 (2008) 277-282
6. Y.Gonnissen, Gonçalves S.I.V., De Geest B.G., Remon J.P., and Vervaet C. Process design applied to optimise a directly compressible powder produced via co-spray drying. Eur. J. Pharm. Biopharm. 68 (2008) 760-770
7. Hicks C.R., and Turner K.V. Fundamental Concepts in the Design of Experiments (1999), Oxford University Press, England
8. Manual Design-Expert version 6.0.10, Stat-Ease Inc., Minneapolis, USA.
9. Röck M., and Schwedes J. Investigations on the caking behaviour of bulk solids-macroscale experiments. Powder Technol. 157 (2005) 121-127
10. Fell J.T., and Newton J.M. The tensile strength of lactose tablets. J. Pharm. Pharmacol. 20 (1968) 657-658
11. Masters K. Spray Drying in Practice (2002), SprayDryConsult Intl, ApS Denmark
12. Al-Asheh S., Jumah R., Banat F., and Hammad S. The use of experimental factorial design for analysing the effect of spray dryer operating variables on the production of tomato powder. Food Bioprod. Process. 81 C2 (2003) 81-88