Utilization of telemetry system to assess the cardiovascular profile of AH-1058, a new cardioselective Ca2+ channel blocker, in conscious dogs

Japanese Journal of Pharmacology

Volumn 85, Issue 3, 2001, Pages 331-334

  Takahara, A ^a   Dohmoto, H ^a   Yoshimoto, R ^a   Sugiyama, A ^a   Hashimoto, K ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

AH 1058; Ca2+ channel blocker; Cardiovascular action

Indexed keywords

4 (5H DIBENZO[A,D]CYCLOHEPT 5 YLIDENE) 1 [3 (3 METHOXY 2 NITROPHENYL) 2 PROPENYL]PIPERIDINE; 4 (5H DIBENZO[A,D]CYCLOHEPTEN 5 YLIDENE) 1 [3 (3 METHOXY 2 NITRO)PHENYL 2 PROPENYL]PIPERIDINE; CALCIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ANGINA PECTORIS; ANIMAL EXPERIMENT; AORTA DISSECTING ANEURYSM; ARTICLE; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RESPONSE; CONCENTRATION RESPONSE; CONSCIOUSNESS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOG; DRUG MECHANISM; DRUG SCREENING; ELECTROCARDIOGRAM; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE PRESSURE; HEART RATE; HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY; INOTROPISM; MALE; NONHUMAN; RECORDER; SYNCOPE; SYSTOLIC BLOOD PRESSURE; TELEMETRY;

EID: 0035067902     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.85.331     Document Type: Article

References (13)

1. Effects of AH-1058, a new antiarrhythmic drug, on experimental arrhythmias and cardiac membrane currents
2. Calcium channel antagonistic effects of AH-1058, a novel antiarrhythmic drug, on guinea-pig myocardium
3. Comparison of cardiovascular effects of a new calcium channel blocker AH-1058 with those of verapamil assessed in blood-perfused canine heart preparations
4. Electrophysiological and cardiohemodynamic effects of a new type of calcium channel blocker AH-1058 assessed by the canine in vivo model
5. Validation of a radiotelemetry system for continuous blood pressure and heart rate monitoring in dogs
6. Validation of a telemetry system for measurement of blood pressure, electrocardiogram and locomotor activity in beagle dogs
7. Pharmacologic characterization of FR172516: A new combined calcium channel-blocking and β-adrenoceptor-blocking agent
8. 2+ channel blocker, AH-1058, assessed in canine arrhythmia models
9. Comparison of electropharmacological effects of verapamil and propranolol assessed in the halothane-anesthetized in vivo canine model under the monitoring of monophasic action potential
10. Differences in cardiovascular profile among calcium antagonists
11. Effects of nifedipine with isoflurane, halothane, or enflurane on automaticity, conduction, and contractilty is isolated guinea pig hearts
12. Comparative haemodynamic effects of lidocaine, mexiletine, and disopyramide
13. Effects of betaxolol on cardiohemodynamics and coronary circulation in anesthetized dogs: Comparison with atenolol and propranolol