Gastrin-Releasing Peptide Receptor in Breast Cancer Mediates Cellular Migration and Interleukin-8 Expression

Journal of Surgical Research

Volumn 156, Issue 1, 2009, Pages 26-31

  Chao, Celia ^a,b   Ives, Kirk ^a   Hellmich, Helen L ^a   Townsend Jr , Courtney M ^a   Hellmich, Mark R ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

bombesin; breast cancer; gastrin releasing peptide receptor; interleukin 8; migration

Indexed keywords

BOMBESIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; GASTRIN RELEASING PEPTIDE; GASTRIN RELEASING PEPTIDE RECEPTOR; INTERLEUKIN 8; MESSENGER RNA;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; COULTER COUNTER; GENE EXPRESSION; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; METASTASIS; MULTIGENE FAMILY; NORTHERN BLOTTING; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM;

BOMBESIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DRUG SYNERGISM; EPIDERMAL GROWTH FACTOR; FEMALE; HUMANS; INTERLEUKIN-8; NEUROTRANSMITTER AGENTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, BOMBESIN; RNA, MESSENGER; UP-REGULATION;

EID: 68649095592     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2009.03.072     Document Type: Article

References (25)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2008. CA Cancer J Clin 58 (2008) 71
2. Giacchetti S., Gauville C., de Cremoux P., et al. Characterization, in some human breast cancer cell lines, of gastrin-releasing peptide-like receptors which are absent in normal breast epithelial cells. Int J Cancer 46 (1990) 293
3. Gugger M., and Reubi J.C. Gastrin-releasing peptide receptors in non-neoplastic and neoplastic human breast. Am J Pathol 155 (1999) 2067
4. Bold R.J., Ishizuka J., Yao C.Z., et al. Bombesin stimulates in vitro growth of human breast cancer independent of estrogen receptors status. Anticancer Res 18 (1998) 4051
5. Miyazaki M., Lamharzi N., Schally A.V., et al. Inhibition of growth of MDA-MB-231 human breast cancer xenografts in nude mice by bombesin/gastrin-releasing peptide (GRP) antagonists RC-3940-II and RC-3095. Eur J Cancer 34 (1998) 710
6. Scopinaro F., Di Santo G.P., Tofani A., et al. Fast cancer uptake of 99mTc-labelled bombesin (99mTc BN1). In Vivo 19 (2005) 1071
7. Parry J.J., Andrews R., and Rogers B.E. MicroPET imaging of breast cancer using radiolabeled bombesin analogs targeting the gastrin-releasing peptide receptor. Breast Cancer Res Treat 101 (2007) 175
8. Schwartsmann G., DiLeone L.P., Horowitz M., et al. A phase I trial of the bombesin/gastrin-releasing peptide (BN/GRP) antagonist RC3095 in patients with advanced solid malignancies. Invest New Drugs 24 (2006) 403
9. Patel O., Shulkes A., and Baldwin G.S. Gastrin-releasing peptide and cancer. Biochim Biophys Acta 1766 (2006) 23
10. Guo Y.S., Hellmich M.R., Wen X.D., et al. Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. J Biol Chem 276 (2001) 22941
11. Davidson N.E., Gelmann E.P., Lippman M.E., et al. Epidermal growth factor receptor gene expression in estrogen receptor-positive and negative human breast cancer cell lines. Mol Endocrinol 1 (1987) 216
12. Yano T., Pinski J., Groot K., et al. Stimulation by bombesin and inhibition by bombesin/gastrin-releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines. Cancer Res 52 (1992) 4545
13. Price J.T., Tiganis T., Agarwal A., et al. Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism. Cancer Res 59 (1999) 5475
14. Corral R.S., Iniguez M.A., Duque J., et al. Bombesin induces cyclooxygenase-2 expression through the activation of the nuclear factor of activated T cells and enhances cell migration in Caco-2 colon carcinoma cells. Oncogene 26 (2007) 958
15. Zheng R., Iwase A., Shen R., et al. Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidase. Oncogene 25 (2006) 5942
16. Freund A., Chauveau C., Brouillet J.P., et al. IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells. Oncogene 22 (2003) 256
17. Levine L., Lucci III J.A., Pazdrak B., et al. Bombesin stimulates nuclear factor-κB activation and expression of proangiogenic factors in prostate cancer cells. Cancer Res 63 (2003) 3495
18. Liebow C., Crean D.H., Lee M.T., et al. Synergistic effects of bombesin and epidermal growth factor on cancers. Proc Natl Acad Sci U S A 91 (1994) 3804
19. Prenzel N., Zwick E., Leserer M., et al. Tyrosine kinase signaling in breast cancer. Epidermal growth factor receptor: Convergence point for signal integration and diversification. Breast Cancer Res 2 (2000) 184
20. Prenzel N., Zwick E., Daub H., et al. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402 (1999) 884
21. Madarame J., Higashiyama S., Kiyota H., et al. Transactivation of epidermal growth factor receptor after heparin-binding epidermal growth factor-like growth factor shedding in the migration of prostate cancer cells promoted by bombesin. Prostate 57 (2003) 187
22. De Larco J.E., Wuertz B.R., Rosner K.A., et al. A potential role for interleukin-8 in the metastatic phenotype of breast carcinoma cells. Am J Pathol 158 (2001) 639
23. Sun B., Schally A.V., and Halmos G. The presence of receptors for bombesin/GRP and mRNA for three receptor subtypes in human ovarian epithelial cancers. Regul Pept 90 (2000) 77
24. Engel J.B., Schally A.V., Halmos G., et al. Targeted cytotoxic bombesin analog AN-215 effectively inhibits experimental human breast cancers with a low induction of multi-drug resistance proteins. Endocr Relat Cancer 12 (2005) 999
25. Cornelio D.B., Roesler R., and Schwartsmann G. Gastrin-releasing peptide receptor as a molecular target in experimental anticancer therapy. Ann Oncol 18 (2007) 1457