Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2-/y mice

Genomics

Volumn 94, Issue 3, 2009, Pages 188-195

  Pawlowski, Traci L ^a,b   Heringer Walther, Silvia ^c   Cheng, Chun Huai ^b   Archie, John G ^a   Chen, Chin Fu ^b   Walther, Thomas ^c   Srivastava, Anand K ^a,b  

^a GREENWOOD GENETIC CENTER   (United States)

^b CLEMSON UNIVERSITY   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Agtr2; Dendritic spine; Expression profiling; Intellectual disability; Learning and memory

Indexed keywords

ACYLTRANSFERASE; ADAPTOR PROTEIN; ANGIOTENSIN 2 RECEPTOR; BINDING PROTEIN; CYCLIN A; KRUPPEL LIKE FACTOR; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN 2; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 2; PHOSPHATIDYLSERINE DECARBOXYLASE; PHOSPHOLIPASE C; PHOSPHOPROTEIN PHOSPHATASE 1; PROSTAGLANDIN E SYNTHASE; RNA; TATA BINDING PROTEIN; UBIQUITIN CONJUGATING ENZYME E2; UNSPECIFIC MONOOXYGENASE; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; BEHAVIOR; BRAIN DEVELOPMENT; BRAIN FUNCTION; CELL ACTIVITY; CONTROLLED STUDY; DENDRITIC SPINE; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; INTELLECTUAL IMPAIRMENT; LEARNING; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; MICROARRAY ANALYSIS; MICROTUBULE; MORPHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERINATAL PERIOD; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SPATIAL MEMORY; UNINDEXED SEQUENCE;

ANIMALS; BIOLOGICAL MARKERS; BRAIN; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTOR, ANGIOTENSIN, TYPE 2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

MUS; RODENTIA;

EID: 68549139879     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2009.05.011     Document Type: Article

References (48)

1. Inlow J.K., and Restifo L.L. Molecular and comparative genetics of mental retardation. Genetics 166 (2004) 835-881
2. Hein L., Barsh G., Pratt R., Dzau V., and Kobilka B. Behavioral and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature 377 (1995) 744-747
3. Ichiki T., et al. Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor. Nature 377 (1995) 748-750
4. Vervoort V.S., et al. AGTR2 mutations in X-linked mental retardation. Science 296 (2002) 2401-2403
5. Bienvenu T., et al. Rare polymorphic variants of the AGTR2 gene in boys with non-specific mental retardation. J. Med. Genet. 40 (2003) 357-359
6. Ylisaukko-ojo T., et al. Identification of two AGTR2 mutations in male patients with non-syndromic mental retardation. Hum. Genet. 114 (2004) 211-213
7. Okuyama S., Sakagawa T., Chaki S., Imagawa Y., Ichiki T., and Inagami T. Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor. Brain Res. 821 (1999) 150-159
8. Sakagawa T., et al. Pain threshold, learning and formation of brain edema in mice lacking the angiotensin II type 2 receptor. Life Sci. 67 (2000) 2577-2585
9. Maul B., et al. Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice. J. Mol. Med. 86 (2008) 563-571
10. Grossman A.W., Elisseou N.M., McKinney B.C., and Greenough W.T. Hippocampal pyramidal cells in adult Fmr1 knockout mice exhibit an immature-appearing profile of dendritic spines. Brain Res. 1084 (2006) 158-164
11. Irwin S.A., Galvez R., and Greenough W.T. Dendritic spine structural anomalies in fragile-X mental retardation syndrome. Cereb. Cortex 10 (2000) 1038-1044
12. Irwin S.A., et al. Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination. Am. J. Med. Genet. 98 (2001) 161-167
13. Grady E.F., Sechi L.A., Griffin C.A., Schambelan M., and Kalinyak J.E. Expression of AT2 receptors in the developing rat fetus. J. Clin. Invest. 88 (1991) 921-933
14. Gendron L., Payet M.D., and Gallo-Payet N. The angiotensin type 2 receptor of angiotensin II and neuronal differentiation: from observations to mechanisms. J. Mol. Endocrinol. 31 (2003) 359-372
15. Knowle D., Ahmed S., and Pulakat L. Identification of an interaction between the angiotensin II receptor sub-type AT2 and the Erb3 receptor, a member of the epidermal growth factor receptor family. Regulatory Peptides 87 (2000) 73-82
16. Nouet S., et al. Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP. J. Biol. Chem. 279 (2004) 28989-28997
17. Pulakat L., et al. Ligand-dependent complex formation between the Angiotensin II receptor subtype AT2 and Na+/H+ exchanger NHE6 in mammalian cells. Peptides 26 (2005) 863-873
18. Senbonmatsu T., et al. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. EMBO J. 22 (2003) 6471-6482
19. Gilfillan G.D., et al. SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome. Am. J. Hum. Genet. 82 (2008) 1003-1010
20. Stroth U., Meffert S., Gallinat S., and Unger T. Angiotensin II and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptor. Mol. Brain Res. 53 (1998) 187-195
21. Bjorkblom B., et al. Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J. Neurosci. 25 (2005) 6350-6361
22. Nuyt A.M., Lenkei Z., Palkovits M., Corvol P., and Llorens-Cortes C. Ontogeny of angiotensin II type 2 receptor mRNA expression in fetal and neonatal rat brain. J. Comp. Neurol. 407 (1999) 193-206
23. Sun Y., Kaksonen M., Madden D.T., Schekman R., and Drubin D.G. Interaction of Sla2p's ANTH domain with PtdIns(4,5)P2 is important for actin-dependent endocytic internalization. Mol. Biol. Cell 16 (2005) 717-730
24. Tararuk T., et al. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. J. Cell Biol. 173 (2006) 265-277
25. Wu L., Iwai M., Li Z., Li J.M., Mogi M., and Horiuchi M. Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression: involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase. J. Hypertens 24 (2006) 123-130
26. Luo J.L., Kamata H., and Karin M. IKK/NF-kappaB signaling: balancing life and death-a new approach to cancer therapy. J. Clin. Invest. 115 (2005) 2625-2632
27. Duechler M., Shehata M., Schwarzmeier J.D., Hoelbl A., Hilgarth M., and Hubmann R. Induction of apoptosis by proteasome inhibitors in B-CLL cells is associated with downregulation of CD23 and inactivation of Notch2. Leukemia 19 (2005) 260-267
28. Leavitt B.R., et al. Wild-type huntingtin protects neurons from excitotoxicity. J. Neurochem. 96 (2006) 1121-1129
29. Rigamonti D., et al. Wild-type huntingtin protects from apoptosis upstream of caspase-3. J. Neurosci. 20 (2000) 3705-3713
30. Zuccato C., et al. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat. Genet. 35 (2003) 76-83
31. Tanaka M., Kadokawa Y., Hamada Y., and Marunouchi T. Notch2 expression negatively correlates with glial differentiation in the postnatal mouse brain. J. Neurobiol. 41 (1999) 524-539
32. Sytnyk V., Leshchyns'ka I., Nikonenko A.G., and Schachner M. NCAM promotes assembly and activity-dependent remodeling of the postsynaptic signaling complex. J. Cell Biol. 174 (2006) 1071-1085
33. Bussolati B., et al. Neural-cell adhesion molecule (NCAM) expression by immature and tumor-derived endothelial cells favors cell organization into capillary-like structures. Exp. Cell Res. 312 (2006) 913-924
34. Reymond N., Fabre S., Lecocq E., Adelaide J., Dubreuil P., and Lopez M. Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. J. Biol. Chem. 276 (2004) 43205-43215
35. von Bohlen und Halbach O., Walther T., Bader M., and Albrecht D. Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice. Regul. Pept. 99 (2001) 209-216
36. Nadif Kasri N., and Van Aelst L. Rho-linked genes and neurological disorders. Pflugers Arch. 455 (2008) 787-797
37. AbdAlla S., Lother H., Abdel-tawab A.M., and Quitterer U. The angiotensin II AT2 receptor is an AT1 receptor antagonist. J. Biol. Chem. 276 (2001) 39721-39726
38. Beaudry H., Gendron L., Guimond M.O., Payet M.D., and Gallo-Payet N. Involvement of protein kinase C alpha (PKC alpha) in the early action of angiotensin II type 2 (AT2) effects on neurite outgrowth in NG108-15 cells: AT2-receptor inhibits PKC alpha and p21ras activity. Endocrinology 147 (2006) 4263-4272
39. Berry C., Touyz R., Dominiczak A.F., Webb R.C., and Johns D.G. Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. Am. J. Physiol. Heart Circ. Physiol. 281 (2001) H2337-2365
40. Li J.M., et al. Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1. Mol. Endocrinol. 21 (2007) 499-511
41. Meffert S., Stoll M., Steckelings U.M., Bottari S.P., Unger T., and The angiotensin I.I. AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol. Cell Endocrinol. 122 (1996) 59-67
42. Clapcote J., and Roder J. Simplex PCR assay for sex determination in mice. Biotechniques 38 (2005) 702-706
43. H. Yee, marray: Exploratory analysis for two-color spotted microarray data, R package version 1.8.0, (2005).
44. Smyth G. Limma: Linear Models for Microarray Data (2005), Springer, New York
45. Rozen S., and Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132 (2000) 365-386
46. Larionov A., Krause A., and Miller W. A standard curve based method for relative real time PCR data processing. BMC Bioinformatics 6 (2005) 62
47. Szabo A., Perou C.M., Karaca M., Perreard L., Quackenbush J.F., and Bernard P.S. Statistical modeling for selecting housekeeper genes. Genome Biol. 5 (2004) R59
48. Dennis Jr. G., Sherman B.T., Hosack D.A., Yang J., Gao W., Lane H.C., and Lempicki R.A. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4 (2003) P3