Stability of amorphous indomethacin in a solid dispersion using crospovidone prepared by a twin-screw kneader or extruder and application of aqueous film-coating to solid dispersion tablets

Journal of Drug Delivery Science and Technology

Volumn 19, Issue 3, 2009, Pages 205-210

  Shibata, Y ^a,b   Fujii, M ^a   Sugamura, Y ^a   Nakanishi, S ^a   Yamada, M ^b   Ouchi, K ^b   Watanabe, Y ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^b KISSEI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Aqueous film coating; Crospovidone; Direct compression; Indomethacin; Manufacturing; Solid dispersion; Stability; Tablet

Indexed keywords

CROSPOVIDONE; INDOMETACIN; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE;

AQUEOUS SOLUTION; ARTICLE; COMPRESSION; CRYSTALLIZATION; DISPERSION; DRUG MANUFACTURE; DRUG STABILITY; DRUG STORAGE; FILM COATING; HUMAN; HUMIDITY; POWDER; TABLET FORMULATION;

EID: 68549130517     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(09)50037-8     Document Type: Article

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