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Volumn 78, Issue 2, 2009, Pages 212-217

Secretory phospholipase A2 inhibitor PX-18 preserves microvascular reactivity after cerebral ischemia in piglets

Author keywords

Bradykinin; Hypercapnia; N methyl d aspartate; Nanosuspension; Pial arteriole

Indexed keywords

BRADYKININ; ENZYME INHIBITOR; N METHYL DEXTRO ASPARTIC ACID; PX 18; SECRETORY PHOSPHOLIPASE A2 INHIBITOR; UNCLASSIFIED DRUG; 2 (N,N BIS(OLEOYLOXYETHYL)AMINO) 1 ETHANESULFONIC ACID; 2-(N,N-BIS(OLEOYLOXYETHYL)AMINO)-1-ETHANESULFONIC ACID; ALKANESULFONIC ACID; N METHYLASPARTIC ACID; OLEIC ACID; SECRETORY PHOSPHOLIPASE A2; VASODILATOR AGENT;

EID: 68549103444     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2009.06.004     Document Type: Article
Times cited : (6)

References (42)
  • 1
    • 0037767185 scopus 로고    scopus 로고
    • Cyclooxygenase-2-dependent superoxide generation contributes to age-dependent impairment of G protein-mediated cerebrovasodilation
    • Armstead W.M. Cyclooxygenase-2-dependent superoxide generation contributes to age-dependent impairment of G protein-mediated cerebrovasodilation. Anesthesiology 98 (2003) 1378-1383
    • (2003) Anesthesiology , vol.98 , pp. 1378-1383
    • Armstead, W.M.1
  • 2
    • 0023688174 scopus 로고
    • Postischemic generation of superoxide anion by newborn pig brain
    • Armstead W.M., et al. Postischemic generation of superoxide anion by newborn pig brain. Am. J. Physiol. 255 (1988) H401-H403
    • (1988) Am. J. Physiol. , vol.255
    • Armstead, W.M.1
  • 3
    • 0032509789 scopus 로고    scopus 로고
    • Inhibitory effects of hypoxia and adenosine on N-methyl-d-aspartate-induced pial arteriolar dilation in piglets
    • Bari F., et al. Inhibitory effects of hypoxia and adenosine on N-methyl-d-aspartate-induced pial arteriolar dilation in piglets. Brain Res. 780 (1998) 237-244
    • (1998) Brain Res. , vol.780 , pp. 237-244
    • Bari, F.1
  • 4
    • 0014935332 scopus 로고
    • Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain
    • Bazan Jr. N.G. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim. Biophys. Acta 218 (1970) 1-10
    • (1970) Biochim. Biophys. Acta , vol.218 , pp. 1-10
    • Bazan Jr., N.G.1
  • 5
    • 0016064945 scopus 로고
    • The fetal and neonatal pig in biomedical research
    • Book S.A., and Bustad L.K. The fetal and neonatal pig in biomedical research. J. Anim. Sci. 38 (1974) 997-1002
    • (1974) J. Anim. Sci. , vol.38 , pp. 997-1002
    • Book, S.A.1    Bustad, L.K.2
  • 6
    • 0012397133 scopus 로고
    • Cerebral Circulation of the Fetus and Newborn
    • Bevan R.D.B. (Ed), Humana Press, Totowa
    • Busija D.W. Cerebral Circulation of the Fetus and Newborn. In: Bevan R.D.B. (Ed). The Human Brain Circulation (1994), Humana Press, Totowa 259-269
    • (1994) The Human Brain Circulation , pp. 259-269
    • Busija, D.W.1
  • 7
    • 0029963005 scopus 로고    scopus 로고
    • Effects of ischemia on cerebrovascular responses to N-methyl-d-aspartate in piglets
    • Busija D.W., et al. Effects of ischemia on cerebrovascular responses to N-methyl-d-aspartate in piglets. Am. J. Physiol. 270 (1996) H1225-H1230
    • (1996) Am. J. Physiol. , vol.270
    • Busija, D.W.1
  • 8
    • 36049010000 scopus 로고    scopus 로고
    • Mechanisms involved in the cerebrovascular dilator effects of N-methyl-d-aspartate in cerebral cortex
    • Busija D.W., et al. Mechanisms involved in the cerebrovascular dilator effects of N-methyl-d-aspartate in cerebral cortex. Brain Res. Rev. 56 (2007) 89-100
    • (2007) Brain Res. Rev. , vol.56 , pp. 89-100
    • Busija, D.W.1
  • 9
    • 47249106478 scopus 로고    scopus 로고
    • Cyclooxygenase inhibition in ischemic brain injury
    • Candelario-Jalil E., and Fiebich B.L. Cyclooxygenase inhibition in ischemic brain injury. Curr. Pharm. Des. 14 (2008) 1401-1418
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 1401-1418
    • Candelario-Jalil, E.1    Fiebich, B.L.2
  • 10
    • 0035930486 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitor NS398 preserves neuronal function after hypoxia/ischemia in piglets
    • Domoki F., et al. Cyclooxygenase-2 inhibitor NS398 preserves neuronal function after hypoxia/ischemia in piglets. NeuroReport 12 (2001) 4065-4068
    • (2001) NeuroReport , vol.12 , pp. 4065-4068
    • Domoki, F.1
  • 11
    • 21644470420 scopus 로고    scopus 로고
    • Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets
    • Domoki F., et al. Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets. Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H368-H373
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289
    • Domoki, F.1
  • 12
    • 57349133682 scopus 로고    scopus 로고
    • Cerebromicrovascular endothelial cells are resistant to l-glutamate
    • Domoki F., et al. Cerebromicrovascular endothelial cells are resistant to l-glutamate. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 (2008) R1099-R1108
    • (2008) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.295
    • Domoki, F.1
  • 13
    • 33646594976 scopus 로고    scopus 로고
    • Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly
    • Farooqui A.A., and Horrocks L.A. Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly. Neuroscientist 12 (2006) 245-260
    • (2006) Neuroscientist , vol.12 , pp. 245-260
    • Farooqui, A.A.1    Horrocks, L.A.2
  • 14
    • 0037378386 scopus 로고    scopus 로고
    • Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs
    • Fiumana E., et al. Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs. Am. J. Physiol. Heart Circ. Physiol. 284 (2003) H1073-H1079
    • (2003) Am. J. Physiol. Heart Circ. Physiol. , vol.284
    • Fiumana, E.1
  • 15
    • 0019292859 scopus 로고
    • Total body glucose metabolism in the conscious, unrestrained piglet and its relation to body- and organ weight
    • Flecknell P.A., et al. Total body glucose metabolism in the conscious, unrestrained piglet and its relation to body- and organ weight. Br. J. Nutr. 44 (1980) 193-203
    • (1980) Br. J. Nutr. , vol.44 , pp. 193-203
    • Flecknell, P.A.1
  • 16
    • 0015318472 scopus 로고
    • Central vasomotor regulation in the newborn piglet Sus scrofa
    • Gootman N., et al. Central vasomotor regulation in the newborn piglet Sus scrofa. Am. J. Physiol. 222 (1972) 994-999
    • (1972) Am. J. Physiol. , vol.222 , pp. 994-999
    • Gootman, N.1
  • 17
    • 0037190825 scopus 로고    scopus 로고
    • Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors
    • Kolko M., et al. Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors. NeuroReport 13 (2002) 1963-1966
    • (2002) NeuroReport , vol.13 , pp. 1963-1966
    • Kolko, M.1
  • 18
    • 0036535411 scopus 로고    scopus 로고
    • Ceramides increase the activity of the secretory phospholipase A2 and alter its fatty acid specificity
    • Koumanov K.S., et al. Ceramides increase the activity of the secretory phospholipase A2 and alter its fatty acid specificity. Biochem. J. 363 (2002) 45-51
    • (2002) Biochem. J. , vol.363 , pp. 45-51
    • Koumanov, K.S.1
  • 19
    • 0036299658 scopus 로고    scopus 로고
    • Hydrogen peroxide acts as an EDHF in the piglet pial vasculature in response to bradykinin
    • Lacza Z., et al. Hydrogen peroxide acts as an EDHF in the piglet pial vasculature in response to bradykinin. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H406-H411
    • (2002) Am. J. Physiol. Heart Circ. Physiol. , vol.283
    • Lacza, Z.1
  • 20
    • 0028238064 scopus 로고
    • Expression of group II phospholipase A2 in rat brain after severe forebrain ischemia and in endotoxic shock
    • Lauritzen I., et al. Expression of group II phospholipase A2 in rat brain after severe forebrain ischemia and in endotoxic shock. Brain Res. 651 (1994) 353-356
    • (1994) Brain Res. , vol.651 , pp. 353-356
    • Lauritzen, I.1
  • 21
    • 0024328919 scopus 로고
    • Cerebral ischemia alters cerebral microvascular reactivity in newborn pigs
    • Leffler C.W., et al. Cerebral ischemia alters cerebral microvascular reactivity in newborn pigs. Am. J. Physiol. 257 (1989) H266-H271
    • (1989) Am. J. Physiol. , vol.257
    • Leffler, C.W.1
  • 22
    • 0026725686 scopus 로고
    • Topical arachidonic acid restores pial arteriolar dilation to hypercapnia of postischemic newborn pig brain
    • Leffler C.W., et al. Topical arachidonic acid restores pial arteriolar dilation to hypercapnia of postischemic newborn pig brain. Am. J. Physiol. 263 (1992) H746-H751
    • (1992) Am. J. Physiol. , vol.263
    • Leffler, C.W.1
  • 23
    • 0027966211 scopus 로고
    • Light/dye microvascular injury selectively eliminates hypercapnia-induced pial arteriolar dilation in newborn pigs
    • Leffler C.W., et al. Light/dye microvascular injury selectively eliminates hypercapnia-induced pial arteriolar dilation in newborn pigs. Am. J. Physiol. 266 (1994) H623-H630
    • (1994) Am. J. Physiol. , vol.266
    • Leffler, C.W.1
  • 24
    • 34547735506 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide induces pial arteriolar vasodilation through cyclooxygenase-dependent and independent mechanisms in newborn pigs
    • Lenti L., et al. Pituitary adenylate cyclase-activating polypeptide induces pial arteriolar vasodilation through cyclooxygenase-dependent and independent mechanisms in newborn pigs. Brain Res. 1165 (2007) 81-88
    • (2007) Brain Res. , vol.1165 , pp. 81-88
    • Lenti, L.1
  • 25
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • Lo E.H., et al. Mechanisms, challenges and opportunities in stroke. Nat. Rev. Neurosci. 4 (2003) 399-415
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 399-415
    • Lo, E.H.1
  • 26
    • 4644309307 scopus 로고    scopus 로고
    • Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology
    • Moschwitzer J., et al. Development of an intravenously injectable chemically stable aqueous omeprazole formulation using nanosuspension technology. Eur. J. Pharm. Biopharm. 58 (2004) 615-619
    • (2004) Eur. J. Pharm. Biopharm. , vol.58 , pp. 615-619
    • Moschwitzer, J.1
  • 27
    • 34547874107 scopus 로고    scopus 로고
    • Drug nanocrystals of poorly soluble drugs
    • Nalwa H.S. (Ed), American Scientific Publishers, New York
    • Müller R.H., and Akkar A. Drug nanocrystals of poorly soluble drugs. In: Nalwa H.S. (Ed). Encyclopedia of Nanoscience and Nanotechnology (2004), American Scientific Publishers, New York 627-638
    • (2004) Encyclopedia of Nanoscience and Nanotechnology , pp. 627-638
    • Müller, R.H.1    Akkar, A.2
  • 28
    • 0002819692 scopus 로고    scopus 로고
    • Nanosuspensions for the formulation of poorly soluble drugs
    • Nielloud F., and Marti-Mestres G. (Eds), Marcel Dekker, New York
    • Müller R.H., et al. Nanosuspensions for the formulation of poorly soluble drugs. In: Nielloud F., and Marti-Mestres G. (Eds). Pharmaceutical Emulsions and Suspensions (2000), Marcel Dekker, New York
    • (2000) Pharmaceutical Emulsions and Suspensions
    • Müller, R.H.1
  • 29
    • 0035937599 scopus 로고    scopus 로고
    • Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future
    • Muller R.H., et al. Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. Adv. Drug Deliv. Rev. 47 (2001) 3-19
    • (2001) Adv. Drug Deliv. Rev. , vol.47 , pp. 3-19
    • Muller, R.H.1
  • 30
    • 68549115539 scopus 로고    scopus 로고
    • PX-18 - a novel inhibitor of phospholipase A(2) induces 'pharmacological preconditioning' in the rabbit heart through opening of mitoK(ATP) channels
    • Ockaili R., et al. PX-18 - a novel inhibitor of phospholipase A(2) induces 'pharmacological preconditioning' in the rabbit heart through opening of mitoK(ATP) channels. FASEB J. 19 (2005) A691
    • (2005) FASEB J. , vol.19
    • Ockaili, R.1
  • 31
    • 0037313972 scopus 로고    scopus 로고
    • Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase
    • Parfenova H., et al. Ionotropic glutamate receptors in cerebral microvascular endothelium are functionally linked to heme oxygenase. J. Cereb. Blood Flow Metab. 23 (2003) 190-197
    • (2003) J. Cereb. Blood Flow Metab. , vol.23 , pp. 190-197
    • Parfenova, H.1
  • 32
    • 0028822708 scopus 로고
    • Prostaglandin G/H synthase-2 is a major contributor of brain prostaglandins in the newborn
    • Peri K.G., et al. Prostaglandin G/H synthase-2 is a major contributor of brain prostaglandins in the newborn. J. Biol. Chem. 270 (1995) 24615-24620
    • (1995) J. Biol. Chem. , vol.270 , pp. 24615-24620
    • Peri, K.G.1
  • 33
    • 0037707816 scopus 로고    scopus 로고
    • Differential role of PTK, ERK and p38 MAPK in superoxide impairment of NMDA cerebrovasodilation
    • Philip S., and Armstead W.M. Differential role of PTK, ERK and p38 MAPK in superoxide impairment of NMDA cerebrovasodilation. Brain Res. 979 (2003) 98-103
    • (2003) Brain Res. , vol.979 , pp. 98-103
    • Philip, S.1    Armstead, W.M.2
  • 34
    • 4544383493 scopus 로고    scopus 로고
    • Nanosuspensions in drug delivery
    • Rabinow B.E. Nanosuspensions in drug delivery. Nat. Rev. Drug Discov. 3 (2004) 785-796
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 785-796
    • Rabinow, B.E.1
  • 35
    • 34247132990 scopus 로고    scopus 로고
    • Prostaglandin production in human coronary artery endothelial cells is modulated differentially by selective phospholipase A(2) inhibitors
    • Rastogi P., et al. Prostaglandin production in human coronary artery endothelial cells is modulated differentially by selective phospholipase A(2) inhibitors. Prostaglandins Leukot. Essent. Fat. Acids 76 (2007) 205-212
    • (2007) Prostaglandins Leukot. Essent. Fat. Acids , vol.76 , pp. 205-212
    • Rastogi, P.1
  • 36
    • 27644548074 scopus 로고    scopus 로고
    • Piglet pial arteries respond to N-methyl-d-aspartate in vivo but not in vitro
    • Simandle S.A., et al. Piglet pial arteries respond to N-methyl-d-aspartate in vivo but not in vitro. Microvasc. Res. 70 (2005) 76-83
    • (2005) Microvasc. Res. , vol.70 , pp. 76-83
    • Simandle, S.A.1
  • 37
    • 53949092998 scopus 로고    scopus 로고
    • Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products
    • Van Eerdenbrugh B., et al. Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products. Int. J. Pharm. 364 (2008) 64-75
    • (2008) Int. J. Pharm. , vol.364 , pp. 64-75
    • Van Eerdenbrugh, B.1
  • 38
    • 0023819690 scopus 로고
    • 2 response in cerebral arteries of the newborn pig: role of phospholipase, cyclooxygenase, and lipoxygenase pathways
    • 2 response in cerebral arteries of the newborn pig: role of phospholipase, cyclooxygenase, and lipoxygenase pathways. Circ. Res. 62 (1988) 1019-1026
    • (1988) Circ. Res. , vol.62 , pp. 1019-1026
    • Wagerle, L.C.1    Mishra, O.P.2
  • 39
    • 68549115538 scopus 로고    scopus 로고
    • 2 inhibitor PX-18 in cerebral ischemia/reperfusion
    • 2 inhibitor PX-18 in cerebral ischemia/reperfusion. J. Neurochem. 102 (2007) 127
    • (2007) J. Neurochem. , vol.102 , pp. 127
    • Wang, Q.1
  • 40
    • 0035661766 scopus 로고    scopus 로고
    • Endothelial NO and prostanoid involvement in newborn and juvenile pig pial arteriolar vasomotor responses
    • Willis A.P., and Leffler C.W. Endothelial NO and prostanoid involvement in newborn and juvenile pig pial arteriolar vasomotor responses. Am. J. Physiol. Heart Circ. Physiol. 281 (2001) H2366-H2377
    • (2001) Am. J. Physiol. Heart Circ. Physiol. , vol.281
    • Willis, A.P.1    Leffler, C.W.2
  • 41
    • 0025736183 scopus 로고
    • Endothelium-dependent responses of cerebral blood vessels during chronic hypertension
    • Yang S.T., et al. Endothelium-dependent responses of cerebral blood vessels during chronic hypertension. Hypertension 17 (1991) 612-618
    • (1991) Hypertension , vol.17 , pp. 612-618
    • Yang, S.T.1
  • 42
    • 0025858127 scopus 로고
    • Mechanisms of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats
    • Yang S.T., et al. Mechanisms of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats. Stroke 22 (1991) 1177-1182
    • (1991) Stroke , vol.22 , pp. 1177-1182
    • Yang, S.T.1


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