The association between onion consumption and bone density in perimenopausal and postmenopausal non-Hispanic white women 50 years and older

Menopause

Volumn 16, Issue 4, 2009, Pages 756-759

  Matheson, Eric M ^a   Mainous, Arch G ^a   Carnemolla, Mark A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Bone density; Onions; Osteoporosis; Quercetin

Indexed keywords

CALCIUM; ESTROGEN; PARATHYROID HORMONE; QUERCETIN; VITAMIN D;

ADULT; AGED; ARTICLE; BODY MASS; BONE DENSITY; CALCIUM INTAKE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOSE TIME EFFECT RELATION; DUAL ENERGY X RAY ABSORPTIOMETRY; EXERCISE; FEMALE; HEALTH SURVEY; HIP FRACTURE; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; ONION; POSTMENOPAUSE OSTEOPOROSIS; RISK ASSESSMENT; SMOKING;

ABSORPTIOMETRY, PHOTON; BODY MASS INDEX; BONE DENSITY; CALCIUM, DIETARY; DIET; ESTROGEN REPLACEMENT THERAPY; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXERCISE; FEMALE; HIP FRACTURES; HUMANS; MIDDLE AGED; NUTRITION SURVEYS; ONIONS; OSTEOPOROSIS, POSTMENOPAUSAL; PARATHYROID HORMONE; PERIMENOPAUSE; POSTMENOPAUSE; RISK FACTORS; SMOKING; VITAMIN D;

EID: 68449097456     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/gme.0b013e31819581a5     Document Type: Article

References (27)

1. Bürge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 2007;22:465-475.
2. Poole KE, Compston JE. Osteoporosis and its management. BMJ 2006;333:1251-1256.
3. Lohman T, Going S, Pamenter R, et al. Effects of resistance training on regional and total bone mineral density in premenopausal women: a randomized prospective study. J Bone Miner Res 1995;10:1015-1024.
4. Kelly PJ, Pocock NA, Sambrook PN, Eisman JA. Dietary calcium, sex hormones, and bone mineral density in men. BMJ 1990;300:1361-1364.
5. Wickham CA, Walsh K, Cooper C, et al. Dietary calcium, physical activity, and risk of hip fracture: a prospective study. BMJ 1989;299:889-892.
6. Orwoll ES, Oviatt SK, McClung MR, Deftos LJ, Sexton G. The rate of bone mineral loss in normal men and the effects of calcium and cholecalciferol supplementation. Ann Intern Med 1990;112:29-34.
7. Jackson RD, LaCroix AZ, Gass M, et al. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 2006;354:669-683.
8. Martyn-St James M, Carroll S. High-intensity resistance training and postmenopausal bone loss: a meta-analysis. Osteoporos Int 2006;17:1225-1240.
9. Muhlbauer RC, Li F. Effect of vegetables on bone metabolism. Nature 1999;401:343-344.
10. Muhlbauer RC, Lozano A, Reinli A. Onion and a mixture of vegetables, salads, and herbs affect bone resorption in the rat by a mechanism independent of their base excess. J Bone Miner Res 2002;17:1230-1236.
11. Wetli HA, Brenneisen R, Tschudi I, et al. A 7-glutamyl peptide isolated from onion (Allium cepa L.) by bioassay-guided fractionation inhibits resorption activity of osteoclasts. J Agric Food Chem 2005;53:3408-3414.
12. Tang CH, Huang TH, Chang CS, Fu WM, Yang RS. Water solution of onion crude powder inhibits RANKL-induced osteoclastogenesis through ERK, p38 and NF-κB pathways. Osteoporos Int 2009;20:93-103.
13. Wartel A, Kamel S, Prouillet C, et al. Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF-κB and AP-1. J Cell Biochem 2004;92:285-295.
14. Miean KH, Mohamed S. Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J Agric Food Chem 2001;49:3106-3112.
15. Prouillet C, Maziere JC, Maziere C, Wattel A, Brazier M, Kamel S. Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochem Pharmacol 2004;67:1307-1313.
16. Tuzun S, Akarirmak U, Uludag M, Tuzun F, Kullenberg R. Is BMD sufficient to explain different fracture rates in Sweden and Turkey? J Clin Densitom 2007;10:285-288.
17. Lucier G. Onions: the sweet smell of success. J Agric Outlook Econ Res Serv 1998;9:5-8.
18. Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Ogelsby AK. International variations in hip fracture probabilities: implications for risk assessment. J Bone Miner Res 2002;17:1237-1244.
19. Design and estimation for the National Health Interview Survey, 1995-2004. Vital Health Stat 2 2000:1-31.
20. Riggs BL, Wahner HW, Dunn WL, Mazess RB, Offord KP, Melton LJ 3rd. Differential changes in bone mineral density of the appendicular and axial skeleton with aging: relationship to spinal osteoporosis. J Clin Invest 1981;67:328-335.
21. Robbins J, Aragaki AK, Kooperberg C, et al. Factors associated with 5-year risk of hip fracture in postmenopausal women. JAMA 2007;298:2389-2398.
22. Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. lancet 2002;359:1929-1936.
23. Orwoll ES, Weigel RM, Oviatt SK, McClung MR, Deftos LJ. Calcium and cholecalciferol: effects of small supplements in normal men. Am J Clin Nutr 1988;48:127-130.
24. Law MR, Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ 1997;315:841-846.
25. Caria H, Chaveca A, Laires J, et al. Genotoxicity of quercetin in the micronucleus assay in mouse bone marrow erythrocytes, human lymphocytes, V79 cell line and identification of kinetochaore-containing (crest staining) micronuclei in human lymphocytes. Mutat Res 1995;343:85-94.
26. Utesch D, Feige K, Dasenbrock J, et al. Evaluation of the potential in vivo toxicity of quercetin. Mutat Res 2008;654:38-44.
27. Wach A, Pyrzyńska K, Biesaga M. Quercetin content in some food and herbal samples. Food Chem 2005;100:699-704.