Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5155-5157

  Yoon, Goo ^a   Lee, Woojung ^a   Kim, Su Nam ^a   Cheon, Seung Hoon ^b  

^a Korea Institute of Science and Technology   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Allyl retrochalcone; Glycyrrhiza inflata; Licochalcone A; Protein tyrosine phosphatase 1B; Semisynthetic

Indexed keywords

ALLYL COMPOUND; CHALCONE DERIVATIVE; ECHINATIN; GLYCYRRHIZA EXTRACT; ISOLIQUIRITIGENIN; LICOCHALCONE A; LICOCHALCONE E; LIQUIRITIGENIN; PROTEIN TYROSINE PHOSPHATASE 1B; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; GLYCYRRHIZA; GLYCYRRHIZA INFLATA; IC 50;

CHALCONES; GLYCYRRHIZA; PLANT EXTRACTS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

GLYCYRRHIZA INFLATA;

EID: 68349160572     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.054     Document Type: Article

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23. PTP1B assay: Recombinant human PTP1B was purchased from BIOMOL International LP. For the inhibition assay, a sample (3 μL in DMSO) was added to a reaction mixture containing enzyme (2 μL), reaction buffer [10 μL, 50 mM citrate (pH 6.0), 0.1 M NaCl, 1 mM EDTA and 1 mM dithiothreitol], water (35 μL) and 50 μL of 4 mM p-nitrophenyl phosphate (pNPP). The reaction mixture (100 μL) was incubated at 37 °C for 30 min and then quenched by addition of 10 μL of 10 N NaOH. The hydrolysis of pNPP was determined by measuring the absorbance at 405 nm.