7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines

Medicinal Chemistry Research

Volumn 10, Issue 1, 2000, Pages 40-49

  Ryu, Chung Kyu ^a   Lee, In Kyung ^a   Jung, Sung Hee ^a   Kang, Hye Young ^a   Lee, Chong Ock ^b  

^a Ewha Womans University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5,8 ISOQUINOLINEDIONE DERIVATIVE; 6 CHLORO 7 (4 ETHOXYPHENYL)AMINO 5,8 ISOQUINOLINEDIONE; 6 CHLORO 7 (4 FLUOROPHENYL)AMINO 5,8 ISOQUINOLINEDIONE; 6 CHLORO 7 (4 METHOXYPHENYL)AMINO 5,8 ISOQUINOLINEDIONE; 6 CHLORO 7 (ETHYLPHENYL)AMINO 5,8 ISOQUINOLINEDIONE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; SOLID TUMOR; STRUCTURE ANALYSIS;

EID: 0033913872     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. 1. Behforouz, M.; Haddad, J.; Cai, W.; Ku, Z. J. Org. Chem. 1998, 63, 343-346 and references therein.
2. 2. Boger, D. L.; Yasuda, M.; Mitscher, L. A.; Drake, S. D.; Kitos, P. A.; Thomson, S. C. J. Med. Chem. 1987, 30, 1918-1928.
3. 3. Lown, J. W.; Sim, S. K. Can. J. Chem. 1976, 54, 2563-2572.
4. 4. Rao, K. V.; Beach, J. W. J. Med. Chem. 1991, 34, 1871-1879.
5. 5. Rao, K. V.; Rock, C. P. J. Heterocycl. Chem. 1996, 33, 447-458.
6. 6. Shaikh, I. A.; Johnson, F.; Grollman, A. P. J. Med. Chem. 1986, 29, 1333-1340.
7. 7. Ryu, C. K.; Lee, I. K.; Jung, S. H.; Lee, C. O. Bioorg. Med. Chem. Lett. 1999, 9, 1075-1080 and references therein.
8. 8. Joseph, P. K.; Jouilie, M. M. J. Med. Chem. 1964, 7, 801-803.
9. 9. Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, T. W.; Bokesch, H.; Kenney, S.; Boyd, M. R. J. Natl. Cancer Inst. 1990, 82, 1107-1112.