Regiochemical control in the amination reaction of phenanthridine-7,10-quinones

Tetrahedron Letters

Volumn 50, Issue 30, 2009, Pages 4361-4363

  Valderrama, Jaime A ^a   Ibacache, J Andrea ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Cytotoxicity; Phenanthridinequinones; Regioselectivity; Substitution reaction

Indexed keywords

7 AMINOISOQUINOLINE 5,8 QUINONE; ANTINEOPLASTIC AGENT; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

AMINATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONTROLLED STUDY; CYCLOADDITION; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; STEREOCHEMISTRY; STOMACH ADENOCARCINOMA; SUBSTITUTION REACTION;

EID: 66449127475     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.05.042     Document Type: Article

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10. 3 [M+]: 318.10044; found: 318.10005.
11. 3: 318.10044; found: 318.10012.
12. 3 [M+]: 332.11609; found: 332.11552.
13. The LUMO eigenvector coefficients were obtained with DFT level in B3LYP/6-31G using the package gaussian 03. Compound 7: C8 = -0.20625, C9 = 0.19330 eV. Compound 8: C8 = -0.20483, C9 = 0.19584 eV.
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