Antiparasitic activities of novel, orally available fumagillin analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5128-5131

  Arico Muendel, Christopher ^a   Centrella, Paolo A ^a   Contonio, Brooke D ^a   Morgan, Barry A ^a   O'Donovan, Gary ^a   Paradise, Christopher L ^a   Skinner, Steven R ^a   Sluboski, Barbara ^a   Svendsen, Jennifer L ^a   White, Kerry F ^a   Debnath, Anjan ^b   Gut, Jiri ^b   Wilson, Nathan ^b   McKerrow, James H ^b   DeRisi, Joseph L ^b   Rosenthal, Philip J ^b   Chiang, Peter K ^c  

^a Praecis Pharmaceuticals Incorporated   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Pharmadyn Inc   (United States)

Author keywords

Amoeba; Antiparasitic; Fumagillin; Malaria; MetAP2; PPI 2458; TNP 470; Trypanosomes

Indexed keywords

ANTIPARASITIC AGENT; ENZYME INHIBITOR; FUMAGILLIN DERIVATIVE; FUMAGILLOL CHLOROACETYLCARBAMATE; METHIONYL AMINOPEPTIDASE 2; PPI 2458; PPI 2788; PPI 2791; UNCLASSIFIED DRUG;

AMOEBA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOSTASIS; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PLASMODIUM; STRUCTURE ACTIVITY RELATION; SURVIVAL; TRYPANOSOMA;

ADMINISTRATION, ORAL; AMINOPEPTIDASES; ANIMALS; ANTIMALARIALS; CYCLOHEXANES; FATTY ACIDS, UNSATURATED; METALLOENDOPEPTIDASES; MICE; PARASITIC SENSITIVITY TESTS; SESQUITERPENES;

MURINAE;

EID: 68349150607     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.029     Document Type: Article

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