Cutaneous lycopene and β-carotene levels measured by resonance Raman spectroscopy: High reliability and sensitivity to oral lactolycopene deprivation and supplementation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 73, Issue 1, 2009, Pages 187-194

  Blume Peytavi, Ulrike ^a,d   Rolland, Anne ^e   Darvin, Maxim E ^b,d   Constable, Anne ^f   Pineau, Isabelle ^e   Voit, Christiane ^c,d   Zappel, Kristina ^a   Schäfer Hesterberg, Gregor ^a,c   Meinke, Martina ^b,d   Clavez, Roger L ^g   Sterry, Wolfram ^d   Lademann, Jürgen ^b  

^a Clinical Research Center for Hair and Skin Science   (Germany)

^b Center of Experimental and Cutaneous Physiology (CCP)   (Germany)

^c Section of Ultrasound Diagnostic   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e L ORÉAL RECHERCHE   (France)

^f NESTLÉ RESEARCH CENTER   (Switzerland)

^g Statistics   (France)

Author keywords

Carotene; Antioxidants; HPLC; Lycopene; Plasma and skin level; Resonance Raman spectroscopy

Indexed keywords

BETA CAROTENE; LYCOPENE; PLACEBO;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; DRUG TOLERABILITY; FEMALE; FOOD DEPRIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NON INVASIVE MEASUREMENT; NORMAL HUMAN; PATIENT COMPLIANCE; PLASMA CONCENTRATION-TIME CURVE; RAMAN SPECTROMETRY; RANDOMIZED CONTROLLED TRIAL; RELIABILITY; SENSITIVITY AND SPECIFICITY; SKINFOLD THICKNESS;

ADMINISTRATION, ORAL; ADULT; BETA CAROTENE; CAROTENOIDS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; MILK PROTEINS; SKIN; SPECTRUM ANALYSIS, RAMAN; YOUNG ADULT;

EID: 68349139721     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.04.017     Document Type: Article

References (33)

1. Kaplan L.A., Lau J.M., and Stein E.A. Carotenoid composition, concentrations, and relationship in various human organs. Clin. Physiol. Biochem. 8 (1990) 1-10
2. Schmitz H.H., Poor C.L., Wellman R.n., and Erdman J.W. Concentrations of selected carotenoids and vitamin A in human liver, kidney and lung tissue. J. Nutr. 121 (1991) 1613-1621
3. Stahl W., Schwarz W., Sundquist A.R., and Sies H. Cis-trans isomers of lycopene and β-carotene in human serum and tissues. Arch. Biochem. Biophys. 294 (1992) 173-177
4. Agarwal S., and Rao A.V. Tomato lycopene and its role in human health and chronic diseases. C. M. A. Y. 163 (2000) 739-744
5. Diplock A.T. Antioxidant nutrients and disease prevention: an overview. Am. J. Clin. Nutr. 53 (1991) 895-1935
6. Greenberg E.R., Baron J.A., Stukel T.A., Stevens M.M., Mandel J.S., Spencer S.K., Elias P.M., Lowe N., Nierenberg D.W., and Bayrd G. A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. The skin cancer prevention study group. N. Engl. J. Med. 323 (1990) 789-795
7. Osganian S.K., Stampfer M.J., Rimm E., Spiegelman D., Manson J.E., and Willett W.C. Dietary carotenoids and risk of coronary artery disease in women. Am. J. Clin. Nutr. 77 (2003) 1390-1399
8. Darwin M.E., Schanzer S., Teichmann A., Blume-Peytavi U., Sterry W., and Lademann J. Functional food und Bioverfügbarkeit im Zielorgan Haut. Hautarzt 57 (2006) 286-290
9. Sander C.S., Chang H., Hamm F., Elsner P., and Thiele J.J. Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis. Inter. J. f. Dermatol. 43 (2004) 326-335
10. Sies H., and Stahl W. Nutritional protection against skin damage from sunlight. Annu. Rev. Nutr. 24 (2004) 173-200
11. Thiele J.J., Schroeter C., Hsieh S.N., Podda M., and Packer L. The antioxidant network of the stratum corneum. Curr. Probl. Dermatol. 29 (2001) 26-42
12. Wrona M., Korytowski W., Rozanowska M., Sarna T., and Truscott T.G. Cooperation of antioxidants in protection against photosensitized oxidation. Free Radical Biol. Med. 35 (2003) 1319-1329
13. Stahl W., Heinrich U., Wiseman S., Eichler O., Sies H., and Tronnier H. Dietary tomato paste protects against ultraviolet light-induced erythema in humans. J. Nutr. 131 (2001) 1449-1451
14. Heinrich U., Gärtner C., Wiebusch M., Eichler O., Sies H., Tronnier H., and Stahl W. Supplementation with (-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema. J. Nutr. 133 (2003) 98-101
15. Heinrich U., Tronnier H., Stahl W., Bejot M., and Maurette J.M. Antioxidant supplements improve parameters related to skin structure in humans. Skin Pharmacol. Physiol. 19 (2006) 224-231
16. Darvin M.E., Zastrow L., Sterry W., and Lademann J. Effect of supplemented topically applied antioxidant substances on human tissue. Skin Pharmacol. Physiol. 19 (2006) 238-247
17. Palombo P., Fabrizi G., Ruocco V., Ruocco E., Fluhr J., Roberts R., and Morganti P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol. Physiol. 20 (2007) 99-210
18. Césarini J.P., Michel L., Maurette J.M., Adhoute H., and Béjot M. Immediate effects of UV radiation on the skin: modification by an antioxidant complex containing carotenoids. Photodermatol. Photoimmunol. Photomed. 19 (2005) 182-189
19. Greul A.K., Grundmann J.U., Heinrich F., Pfitzner I., Bernhardt J., Ambach A., Biesalski H.K., and Gollnick H. Photoprotection of UV-irradiated human skin: an antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacol. Appl. Skin Physiol. 15 (2002) 307-315
20. Eichler O., Sies H., and Stahl W. Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst. Photochem. Photobiol. 75 (2002) 503-506
21. Lee J., Jiang Sh., Levine N., and Watson R.R. Carotenoid supplementation reduces erythema in human skin after simulated solar radiation exposure. P. S. E. B. M. 233 (2000) 170-174
22. Sies H., and Stahl W. Carotenoids and UV protection. Photochem. Photobiol. Sci. 3 (2004) 749-752
23. Schierle J., Bretzel W., Bühler I., Faccin N., Hess D., Steiner K., and Schüep W. Content and isomeric ratio of lycopene in food and human plasma. Food Chem. 59 (1997) 459-465
24. Gärtner C., Stahl W., and Sies H. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am. J. Clin. Nutr. 6 (1997) 16-122
25. van het Hof K.H., de Boer B.C.J., Tijburg L.B.M., Lucius B.R.H., Zijp I., West C.E., Hautvast J.G.A.J., and Westrade J.A. Carotenoid bioavailability in humans from tomatoes processed in different ways determined from the carotenoid response in the triglyceride-rich lipoprotein fraction of plasma after a single consumption and in plasma after four days of consumption. J. Nutr. 130 (2000) 1189-1196
26. Stahl W., and Sies H. Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans. J. Nutr. 122 (1992) 2161-2166
27. Darwin M.E., Gersonde I., Albrecht H., Jacobi U., Sterry W., and Lademann J. Nicht-invasive Bestimmung von β-Carotin und Lycopin in der menschlichen Haut. Laborwelt 4 (2003) 5-10
28. Darvin M.E., Gersonde I., Meinke M., Sterry W., and Lademann J. Non-invasive in vivo determination of the carotenoids beta-carotene and lycopene concentrations in the human skin using the Raman spectroscopic method. J. Phys. D. Appl. Phys. 38 (2005) 1-5
29. Hess D., Keller H.E., Oherlin B., Bonfanti R., and Schüep W. Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase. Internat. J. Vit. Nutr. Res. 61 (1991) 232-238
30. Talwar D., Ha T.K.K., Cooney J., Brownlee C., and O'Reilly D.J.St. A routine method for the simultaneous measurement of retinol, alpha-tocopherol and 5 carotenoids in human plasma by reverse phase HPLC. Clin. Chim. Acta 270 (1998) 85-100
31. Richelle M., Bortlik K., Liardet S., Hager C., Lambelet P., Baur M., Applegate L.A., and Offord E.A. A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste. J. Nutr. 132 (2002) 404-408
32. Thiele J.J., Weber S.U., and Packer L. Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. J. Invest. Dermatol. 113 (1999) 1006-1010
33. Stahl W., Heinrich U., Jungmann H., von Laar J., Schietzel M., Sies H., and Tronnier H. Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting betatene. J. Nutr. 128 (1998) 903-907