Antimicrobial therapy in neonatal foals

Equine Veterinary Education

Volumn 21, Issue 8, 2009, Pages 436-448

  Corley, K T T ^a   Hollis, A R ^a  

^a Anglesey Lodge Equine Hospital   (Ireland)

Author keywords

Antibiotic; Bacterial infection; Horse; Prophylactic administration; Septicaemia

Indexed keywords

BACTERIA (MICROORGANISMS); EQUIDAE;

EID: 68349123716     PISSN: 09577734     EISSN: None     Source Type: Journal    
DOI: 10.2746/095777309X445352     Document Type: Article

References (71)

1. Adams, S.B. and Fessler, J.F. (1987) Umbilical cord remnant infections in foals: 16 cases (1975-1985). J. Am. Vet. med. Ass. 190, 316-318.
2. Arroyo, L.G., Weese, J.S. and Staempfli, H.R. (2004) Experimental Clostridium difficile enterocolitis in foals. J. Vet. intern. Med. 18, 734-738.
3. Baggot, J.D., Love, D.N., Rose, R.J. and Raus, R. (1985) Selection of an aminoglycoside antibiotic for administration to horses. Equine Vet. J. 17, 30-34.
4. Baverud, V., Gustafsson, A., Franklin, A., Aspan, A. and Gunnarsson, A. (2003) Clostridium difficile: prevalence in horses and environment, and antimicrobial susceptibility. Equine Vet. J. 35, 465-471.
5. Benedice, D. (2008) Septicemia in foals. Merck Veterinary Manual. www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/53200. htm, 30th July 2008.
6. Bousquet-Melou, A., Bernard, S., Schneider, M. and Toutain, P.L. (2002) Pharmacokinetics of marbofloxacin in horses. Equine Vet. J. 34, 366-372.
7. Bucki, E.P., Giguere, S., Macpherson, M. and Davis, R. (2004) Pharmacokinetics of once-daily amikacin in healthy foals and therapeutic drug monitoring in hospitalized equine neonates. J. Vet. intern. Med. 18, 728-733.
8. Butler, K.M. (2006) Enterococcal infection in children. Semin. Pediatr. Infect. Dis. 17, 128-139.
9. Butters, A. (2008) Medical and surgical management of uroperitoneum in a foal. Can. Vet. J. 49, 401-403.
10. Carretero, M., Rodriguez, C., San Andres, M.I., Fores, P., de Lucas, J.J., Nieto, J., Waxman, S., San Andres, M.D. and Gonzalez, F. (2002) Pharmacokinetics of marbofloxacin in mature horses after single intravenous and intramuscular administration. Equine Vet. J. 34, 360-365.
11. Carrillo, N.A., Giguere, S., Gronwall, R.R., Brown, M.P., Merritt, K.A. and O'Kelley, J.J. (2005) Disposition of orally administered cefpodoxime proxetil in foals and adult horses and minimum inhibitory concentration of the drug against common bacterial pathogens of horses. Am. J. Vet. Res. 66, 30-35.
12. Cervantes, C.C., Brown, M.P., Gronwall, R. and Merritt, K. (1993) Pharmacokinetics and concentrations of ceftiofur sodium in body fluids and endometrium after repeated intramuscular injections in mares. Am. J. Vet. Res. 54, 573-575.
13. Chaffin, M.K., Cohen, N.D. and Martens, R.J. (2008) Chemoprophylactic effects of azithromycin against Rhodococcus equi-induced pneumonia among foals at equine breeding farms with endemic infections. J. Am. Vet. med. Ass. 232, 1035-1047.
14. Chatterjee, I., Iredell, J.R., Woods, M. and Lipman, J. (2007) The implications of enterococci for the intensive care unit. Crit. Care Resusc. 9, 69-75.
15. Cohen, N.D. (1994) Causes of and farm management factors associated with disease and death in foals. J. Am. Vet. med. Ass. 204, 1644-1651.
16. Corley, K.T., Pearce, G., Magdesian, K.G. and Wilson, W.D. (2007) Bacteraemia in neonatal foals: clinicopathological differences between Gram-positive and Gram-negative infections, and single organism and mixed infections. Equine Vet. J. 39, 84-89.
17. Corley, K.T.T., Donaldson, L.L. and Furr, M.O. (2005) Arterial lactate concentration, hospital survival, sepsis and SIRS in critically ill neonatal foals. Equine Vet. J. 37, 53-59.
18. Dowling, P.M. (2001) Florfenicol in horses: pharmacokinetics and tolerance. In: Proceedings of the American College of Veterinary Internal Medicine, Denver. p 198.
19. Edwards, D.J., Love, D.N., Raus, J. and Baggott, J.D. (1989) The nephrotoxic potential of neomycin in the horse. Equine Vet. J. 21, 206-210.
20. Ensink, J.M., Klein, W.R., Mevius, D.J., Klarenbeek, A. and Vulto, A.G. (1992) Bioavailability of oral penicillins in the horse: a comparison of pivampicillin and amoxicillin. J. Vet. Pharmacol. Ther. 15, 221-230.
21. Fuentes, V.O., Gonzalez, H., Sanchez, V., Fuentes, P. and Rosiles, R. (1997) The effect of neomycin on the kidney function of the horse. Zentralbl. Veterinarmed. A 44, 201-205.
22. Furr, M. (2003) Systemic inflammatory response syndrome, sepsis and antimicrobial therapy. Clin. Tech. Equine Pract. 2, 3-8.
23. Giguere, S. (2008a) Antimicrobial therapy. In: The Equine Hospital Manual, 1st edn., Eds: K.T.T. Corley and J.O. Stephen, Blackwell, Oxford. pp. 337-361.
24. Giguere, S. (2008b) Prevalence of Rhodococcus equi isolates resistant to macrolides or rifampin and outcome of infected foals [abstract]. J. Vet. intern. Med. 22, 737.
25. Giguere, S., Jacks, S., Roberts, G.D., Hernandez, J., Long, M.T. and Ellis, C. (2004) Retrospective comparison of azithromycin, clarithromycin, and erythromycin for the treatment of foals with Rhodococcus equipneumonia. J. Vet. intern. Med. 18, 568-573.
26. Hollis, A.R., Wilkins, P.A., Palmer, J.E. and Boston, R.C. (2008) Bacteremia in equine neonatal diarrhea: A retrospective study (1990-2007). J. Vet. intern. Med. 22, 1203-1209.
27. Hulten, C. and Demmers, S. (2002) Serum amyloid A (SAA) as an aid in the management of infectious disease in the foal: comparison with total leucocyte count, neutrophil count and fibrinogen. Equine Vet. J. 34, 693-698.
28. Jacks, S., Giguere, S., Gronwall, R.R., Brown, M.P. and Merritt, K.A. (2002) Disposition of oral clarithromycin in foals. J. Vet. Pharmacol. Ther. 25, 359-362.
29. Jang, S.S., Hansen, L.M., Breher, J.E., Riley, D.A., Magdesian, K.G., Madigan, J.E., Tang, Y.J., Silva, J., Jr. and Hirsh, D.C. (1997) Antimicrobial susceptibilities of equine isolates of Clostridium difficile and molecular characterization of metronidazole-resistant strains. Clin. Infect. Dis. 25, Suppl. 2, S266-267.
30. Kol, A., Steinman, A., Levi, O., Haik, R. and Johnston, D.E. (2005) Congenital pyloric stenosis in a foal. Isr. J. Vet. Med. 60, 59-62.
31. Kumar, A., Roberts, D., Wood, K.E., Light, B., Parrillo, J.E., Sharma, S., Suppes, R., Feinstein, D., Zanotti, S., Taiberg, L., Gurka, D. and Cheang, M. (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit. Care Med. 34, 1589-1596.
32. Leonard, F.C. and Markey, B.K. (2008) Methicillin-resistant Staphylococcus aureus in animals: a review. Vet. J. 175, 27-36.
33. Love, D.N., Rose, R.J., Martin, I.C. and Bailey, M. (1981) Serum levels of amoxycillin following its oral administration to Thoroughbred foals. Equine Vet. J. 13, 53-55.
34. Magdesian, K.G., Hirsh, D.C., Jang, S.S., Hansen, L.M. and Madigan, J.E. (2002) Characterization of Clostridium difficile isolates from foals with diarrhea: 28 cases (1993-1997). J. Am. Vet. Med. Ass. 220, 67-73.
35. Marsh, P.S. and Palmer, J.E. (2001) Bacterial isolates from blood and their susceptibility patterns in critically ill foals: 543 cases (1991-1998). J. Am. Vet. Med. Ass. 218, 1608-1610.
36. McKellar, Q.A. and Varma, K.J. (1996) Pharmacokinetics and tolerance of florfenicol in equidae. Equine Vet. J. 28, 209-213.
37. McKenzie, H.C. and Furr, M.O. (2003) Aminoglycoside antibiotics in neonatal foals. Comp. cont. Educ. pract. Vet. 25, 457-469.
38. Moellering, R.C., Jr. (1992) Emergence of Enterococcus as a significant pathogen. Clin. Infect. Dis. 14, 1173-1176.
39. O'Mahony, R., Abbott, Y., Leonard, F.C., Markey, B.K., Quinn, P.J., Pollock, P.J., Fanning, S. and Rossney, A.S. (2005) Methicillin-resistant Staphylococcus aureus (MRSA) isolated from animals and veterinary personnel in Ireland. Vet. Microbiol. 109, 285-296.
40. Olsen, L., Ingvast-Larsson, C., Brostrom, H., Larsson, P. and Tjalve, H. (2007) Clinical signs and etiology of adverse reactions to procaine benzylpenicillin and sodium/potassium benzylpenicillin in horses. J. Vet. Pharmacol. Ther. 30, 201-207.
41. Orsini, J.A., Moate, P.J., Boston, R.C., Norman, T., Engiles, J., Benson, C.E. and Poppenga, R. (2005a) Pharmacokinetics of imipenem cilastatin following intravenous administration in healthy adult horses. J. Vet. Pharmacol. Ther. 28, 355-361.
42. Orsini, J.A., Snooks-Parsons, C., Stine, L., Haddock, M., Ramberg, C.F., Benson, C.E. and Nunamaker, D.M. (2005b) Vancomycin for the treatment of methicillin-resistant staphylococcal and enterococcal infections in 15 horses. Can. J. Vet. Res. 69, 278-286.
43. Paradis, M.R. (1994) Update on neonatal septicemia. Vet. Clin. N. Am.: Equine Pract. 10, 109-135.
44. Platt, H. (1977) Joint-ill and other bacterial infections on Thoroughbred studs. Equine Vet. J. 9, 141-145.
45. Reef, V.B., Collatos, C., Spencer, P.A., Orsini, J.A. and Sepesy, L.M. (1989) Clinical, ultrasonographic, and surgical findings in foals with umbilical remnant infections. J. Am. Vet. Med. Ass. 195, 69-72.
46. Ringger, N.C., Brown, M.P., Kohlepp, S.J., Gronwall, R.R. and Merritt, K. (1998) Pharmacokinetics of ceftriaxone in neonatal foals. Equine Vet. J. 30, 163-165.
47. Ringger, N.C., Pearson, E.G., Gronwall, R. and Kohlepp, S.J. (1996) Pharmacokinetics of ceftriaxone in healthy horses. Equine Vet. J. 28, 476-479.
48. Rossdale, P.D., Ousey, J.C., Silver, M. and Fowden, A. (1984) Studies on equine prematurity 6: Guidelines for assessment of foal maturity. Equine Vet. J. 16, 300-302.
49. Roussel, A.J., Hooper, R.N., Cohen, N.D., Bye, A.D., Hicks, R.J. and Schulze, J.L. (2003) Evaluation of the effects of penicillin G potassium and potassium chloride on the motility of the large intestine in horses. Am. J. Vet. Res. 64, 1360-1363.
50. Russell, C.M., Axon, J.E., Blishen, A. and Begg, A.P. (2008) Blood culture isolates and antimicrobial sensitivities from 427 critically ill neonatal foals. Aust. Vet. J. 86, 266-271.
51. Salmon, S.A., Watts, J.L. and Yancey, R.J.J. (1996) In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance. J. Vet. diag. Invest. 8, 332-336.
52. Samitz, E.M., Jang, S.S. and Hirsh, D.C. (1996) In vitro susceptibilities of selected obligate anaerobic bacteria obtained from bovine and equine sources to ceftiofur. J. Vet. diag. Invest. 8, 121-123.
53. Sampieri, F., Hinchcliff, K.W. and Toribio, R.E. (2006) Tetracycline therapy of Lawsonia intracellularis enteropathy in foals. Equine Vet. J. 38, 89-92.
54. Slovis, N.M., Wilson, W.D., Stanley, S.D., Lakritz, J., Mihalyi, J. and Kollias-Baker, C. (2006) Comparative pharmacokinetics and bioavailability of ceftiofur in horses after intravenous, intramuscular, and subcutaneous administration. Proc. Am. Ass. equine Practnrs. 52, 329-330.
55. Smith, L.J., Marr, C.M., Payne, R.J., Stoneham, S.J. and Reid, S.W. (2004) What is the likelihood that Thoroughbred foals treated for septic arthritis will race? Equine Vet. J. 36, 452-456.
56. Spensley, M.S., Carlson, G.P. and Harrold, D. (1987) Plasma, red blood cell, total blood, and extracellular fluid volumes in healthy horse foals during growth. Am. J. Vet. Res. 48, 1703-1707.
57. Steel, C.M., Hunt, A.R., Adams, P.L., Robertson, I.D., Chicken, C., Yovich, J.V. and Stick, J.A. (1999) Factors associated with prognosis for survival and athletic use in foals with septic arthritis: 93 cases (1987-1994). J. Am. Vet. Med. Ass. 215, 973-977.
58. Stewart, A.J., Hinchcliff, K.W., Saville, W.J., Jose-Cunilleras, E., Hardy, J., Kohn, C.W., Reed, S.M. and Kowalski, J.J. (2002) Actinobacillus sp. bacteremia in foals: clinical signs and prognosis. J. Vet. intern. Med. 16, 464-471.
59. Stoneham, S.J., Palmer, L., Cash, R. and Rossdale, P.D. (2001) Measurement of serum amyloid A in the neonatal foal using a latex agglutination immunoturbidimetric assay: determination of the normal range, variation with age and response to disease. Equine Vet. J. 33, 599-603.
60. Sweeney, R.W., Beech, J. and Simmons, R.D. (1988) Pharmacokinetics of intravenously and intramuscularly administered ticarcillin and clavulanic acid in foals. Am. J. Vet. Res. 49, 23-26.
61. Sweeney, R.W., Sweeney, C.R., Soma, L.R., Woodward, C.B. and Charlton, C.A. (1986) Pharmacokinetics of metronidazole given to horses by intravenous and oral routes. Am. J. Vet. Res. 47, 1726-1729.
62. Thomas, E., Thomas, V. and Wilhelm, C. (2006) Antibacterial activity of cefquinome against equine bacterial pathogens. Vet. Microbiol. 115, 140-147.
63. Van den Eede, A., Martens, A., Lipinska, U., Struelens, M., Deplano, A., Denis, O., Haesebrouck, F., Gasthuys, F. and Hermans, K. (2009) High occurrence of methicillin-resistant Staphylococcus aureus ST398 in equine nasal samples. Vet. Microbiol. 133, 138-144.
64. Weese, J.S., Archambault, M., Willey, B.M., Hearn, P., Kreiswirth, B.N., Said-Salim, B., McGeer, A., Likhoshvay, Y., Prescott, J.F. and Low, D.E. (2005) Methicillin-resistant Staphylococcus aureus in horses and horse personnel, 2000-2002. Emerg. Infect. Dis. 11, 430-435.
65. Weese, J.S., Rousseau, J., Willey, B.M., Archambault, M., McGeer, A. and Low, D.E. (2006) Methicillin-resistant Staphylococcus aureus in horses at a veterinary teaching hospital: frequency, characterization, and association with clinical disease. J. Vet. intern. Med. 20, 182-186.
66. Wheeless, C.R. (2008) Metronidazole/Flagyl. http://www.wheelessonline.com/ortho/metronidazole_flagyl, Accessed 28th Aug 2008.
67. Wilson, W.D., Spensley, M.S., Baggot, J.D. and Hietala, S.K. (1988) Pharmacokinetics and estimated bioavailability of amoxicillin in mares after intravenous, intramuscular, and oral administration. Am. J. Vet. Res. 49, 1688-1694.
68. Wilson, W.D., Spensley, M.S., Baggot, J.D., Hietala, S.K. and Pryor, P. (1991) Pharmacokinetics and bioavailability of ticarcillin and clavulanate in foals after intravenous and intramuscular administration. J. Vet. Pharmacol. Ther. 14, 78-89.
69. Wohlfender, F.D., Barrelet, F.E., Doherr, M.G., Straub, R. and Meier, H.P. (2008) Diseases in neonatal foals. Part I: The 30 day incidence of disease and the effect of prophylactic antimicrobial drug treatment during the first three days post partum. Equine Vet. J. 41, 179-185.
70. Womble, A., Giguere, S. and Lee, E.A. (2007) Pharmacokinetics of oral doxycycline and concentrations in body fluids and bronchoalveolar cells of foals. J. Vet. Pharmacol. Ther. 30, 187-193.
71. Wong, D.M., Papich, M.G. and Davis, J.L. (2008) Exposure to phenobarbital in a foal after nursing a mare treated with phenobarbital. J. Vet. intern. Med. 22, 227-230.