Mechanisms of γ-hydroxybutyric acid production during the early postmortem period

Forensic Toxicology

Volumn 27, Issue 2, 2009, Pages 55-60

  Nishimura, Hiroyuki ^a   Moriya, Fumio ^b   Hashimoto, Yoshiaki ^a  

^a KOCHI UNIVERSITY   (Japan)

^b KAWASAKI UNIVERSITY OF MEDICAL WELFARE   (Japan)

Author keywords

Hydroxybutyric acid; Early postmortem period; Endogenous production; Gas chromatography; Succinic acid; Succinic semialdehyde dehydrogenase

Indexed keywords

4 AMINOBUTYRIC ACID; 4 HYDROXYBUTYRIC ACID; ALDEHYDE DEHYDROGENASE INHIBITOR; DIETHYLDITHIOCARBAMIC ACID; PYRAZOLE; SUCCINATE SEMIALDEHYDE DEHYDROGENASE; VALPROIC ACID;

ARTICLE; AUTOPSY; BLOOD SAMPLING; BURN; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME DENATURATION; ENZYME SYNTHESIS; GAS CHROMATOGRAPHY; HEAT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER; LIVER HOMOGENATE; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ORYCTOLAGUS CUNICULUS;

EID: 68349105801     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-009-0067-0     Document Type: Article

References (29)

1. M. Maitre C. Andriamampandry V. Kemmel C. Schmidt Y. Hod V. Hechler S. Gobaille 2000 Gammahydroxybutyric acid as a signaling molecule in brain Alcohol 20 277 283
2. S. Mazarr-Proo S. Kerrigan 2005 Distribution of GHB in tissues and fluids following a fatal overdose J Anal Toxicol 29 398 400
3. A. Waszkielewicz J. Bojarski 2004 γ-Hydroxybutyric acid (GHB) and its chemical modifications: a review of the GHBergic system Pol J Pharmacol 56 43 49
4. C.G. Wong K.M. Gibson O.C. Snead III 2004 From the street to the brain: neurobiology of the recreational drug γ-hydroxybutyric acid Trends Pharmacol Sci 25 29 34
5. T. Nelson E. Kaufman J. Kline L. Sokoloff 1981 The extraneural distribution of γ-hydroxybutyrate J Neurochem 37 1345 1348
6. 3H]aminobutyric acid to γ-[3H]hydroxybutyric acid by rat brain J Neurochem 28 1069 1073
7. A.A. Elian 2002 Determination of endogenous gammahydroxybutyric acid (GHB) levels in antemortem urine and blood Forensic Sci Int 128 120 122
8. N. Shima A. Miki T. Kamata M. Katagi H. Tsuchihashi 2005 Endogenous level and in vitro production of GHB in blood from healthy humans, and the interpretation of GHB levels detected in antemortem blood samples J Health Sci 51 147 154
9. M.A. LeBeau M.A. Montgomery C. Morris-Kukoski J.E. Schaff A. Deakin B. Levine 2006 A comprehensive study on the variations in urinary concentrations of endogenous gammahydroxybutyrate (GHB) J Anal Toxicol 30 98 105
10. F. Moriya H. Nishimura J. Furumiya Y. Hashimoto 2006 Effects of drinking and smoking on endogenous levels of urinary γ-hydroxybutyric acid, a preliminary study Legal Med 8 231 234
11. P. Kintz M. Villain V. Cirimele B. Ludes 2004 GHB in postmortem toxicology. Discrimination between endogenous production from exposure using multiple specimens Forensic Sci Int 143 177 181
12. S.P. Elliott 2004 Further evidence for the presence of GHB in postmortem biological fluid: implications for the interpretation of findings J Anal Toxicol 28 20 26
13. F. Moriya Y. Hashimoto 2005 Site-dependent production of γ-hydroxybutyric acid in the early postmortem period Forensic Sci Int 148 139 142
14. Marinetti LJ (2001) γ-Hydroxybutyric acid and its analogs, γ-butyrolactone and 1,4-butanediol. In: Salamore SJ (ed) Benzodiazepines and GHB: detection and pharmacology. Humana, Totowa, pp 95-126
15. S. Elliott P. Lowe A. Symonds 2004 The possible influence of micro-organisms and putrefaction in the production of GHB in post-mortem biological fluid Forensic Sci Int 139 183 190
16. S.A. Barker O.C. Snead F. Poldrugo C.C. Liu F.P. Fish R.L. Settine 1985 Identification and quantitation of 1,4-butanediol in mammalian tissues: an alternative biosynthetic pathway for gamma-hydroxybutyric acid Biochem Pharmacol 34 1849 1852
17. L.D. Bergelson V.A. Vaver N.V. Prokazova A.N. Ushakov G.A. Popkova 1966 Diol lipids Biochim Biophys Acta 116 511 520
18. F. Moriya H. Nishimura Y. Hashimoto 2005 Detection of γ-hydroxybutyric acid in blood and urine by gas chromatography combined with liquid-liquid extraction Jpn J Forensic Toxicol 23 198 201
19. S. Fushiya T. Kanazawa S. Nozoe 1997 A novel class of potent γ-aminobutyric acid aminotransferase inhibitor, 3-(hydroxyamino) propylamine and analogues Bioorg Med Chem 5 2089 2094
20. S. Kumar N.S. Punekar 1998 Inhibition of succinic semialdehyde dehydrogenase by N-formylglycine J Enzyme Inhib 13 369 376
21. J.P. Lam D.C. Mays J.J. Lipsky 1997 Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram Biochemistry 36 13748 13754
22. F. Moriya Y. Hashimoto 2003 Postmortem formation of γ- hydroxybutyric acid in blood Jpn J Forensic Toxicol 21 262 269
23. D. Richard B. Ling N. Authier T.W. Faict A. Eschalier F. Coudor 2005 GC/MS profiling of γ-hydroxybutyrate and precursors in various animal tissues using automatic solidphase extraction. Preliminary investigations of its potential interest in postmortem interval determination Anal Chem 77 1354 1360
24. M. Eli F. Cattabeni 1983 Endogenous γ-hydroxybutyrate in rat brain areas: postmortem changes and effects of drugs interfering with γ-aminobutyric acid metabolism J Neurochem 41 524 530
25. K. Sakurada M. Kobayashi H. Iwase M. Yoshino H. Mukoyama T. Takatori K. Yoshida 2002 Production of γ-hydroxybutyric acid in postmortem liver increases with time after death Toxicol Lett 129 207 217
26. M. Mamelak 1989 Gammahydroxybutyrate: an endogenous regulator of energy metabolism Neurosci Biobehav Rev 13 187 198
27. R.J. Drummond A.T. Phillips 1974 l-Glutamic acid decarboxylase in non-neural tissues of the mouse J Neurochem 23 1207 1213
28. T.L. Perry S. Hansen S.S. Gandham 1981 Postmortem changes of amino compounds in human and rat brain J Neurochem 36 406 412
29. H.K. Bhargava S. Telang 1986 Postmortem changes in the enzymes of GABA and glutamate metabolism in the cerebellum and forebrain of newborn and adult rats Neurochem Res 11 1473 1478