Effects of drinking and smoking on endogenous levels of urinary γ-hydroxybutyric acid, a preliminary study

Legal Medicine

Volumn 8, Issue 4, 2006, Pages 231-234

  Moriya, Fumio ^a   Nishimura, Hiroyuki ^a   Furumiya, Junichi ^a   Hashimoto, Yoshiaki ^a  

^a KOCHI UNIVERSITY   (Japan)

Author keywords

Drinking; Endogenous hydroxybutyric acid (GHB); Gas chromatography; Smoking; Urinary concentration

Indexed keywords

4 HYDROXYBUTYRIC ACID; ALCOHOL; ANTIDEPRESSANT AGENT; CENTRAL STIMULANT AGENT; NICOTINE;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; SMOKING; STIMULUS RESPONSE; URINALYSIS; URINE LEVEL; VOLUNTEER;

ADULT; ALCOHOL DRINKING; CHROMATOGRAPHY, GAS; FEMALE; HUMANS; MALE; SMOKING; SODIUM OXYBATE;

EID: 33746323012     PISSN: 13446223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.legalmed.2006.05.001     Document Type: Article

References (17)

1. Vayer P., Mander P., and Maitre M. Gamma-hydroxybutyrate, a possible neurotransmitter. Life Sci 41 (1987) 1547-1557
2. Marinetti L.M. γ-Hydroxybutyric acid and its analogs, γ-butyrolactone and 1,4-butanediol. In: Salamore S.J. (Ed). Benzodiazepines and GHB: detection and pharmacology (2001), Humana Press, Totowa 95-126
3. Snead III O.C. Evidence for a G-protein-coupled gamma-hydroxybutyric acid receptor. J Neurochem 75 (2000) 1986-1996
4. Snead III O.C., and Liu C.C. Gamma-hydroxybutyric acid binding sites in rat and human brain synaptosomal membranes. Biochem Pharmacol 33 (1984) 2587-2590
5. Maitre M., Hechler V., Vayer P., Gobaille S., Cash C.D., Schmitt M., and Bourguignon J.J. A specific γ-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties. J Pharmacol Exp Ther 255 (1990) 657-663
6. B) receptor in rat brain. Biochem Pharmacol 52 (1996) 1235-1243
7. Cash C.D., Gobaille S., Kemmel V., Andriamampandry C., and Maitre M. γ-Hydroxybutyrate receptor function studied by the modulation of nitric oxide synthase activity in rat frontal cortex punches. Biochem Pharmacol 58 (1999) 1815-1819
8. B receptors. Neuropharmacol 38 (1999) 1667-1673
9. Anderson DT, Kuwahara T. Endogenous gamma hydroxybutyrate (GHB) levels in postmortem specimens. Presented at the combined meeting of CAT/NWAFS/SWAFS/SAT in Las Vegas, NV; November 7, 1997.
10. Fieler E.L., Coleman D.E., and Baselt R.C. γ-Hydroxybutyrate concentrations in pre- and postmortem blood and urine. Clin Chem 44 (1998) 692
11. Stephens B.G., Coleman D.E., and Baselt R.C. In vitro stability of endogenous gamma-hydroxybutyrate in postmortem blood. J Forensic Sci 44 (1999) 231
12. Moriya F., and Hashimoto Y. Postmortem formation of γ-hydroxybutyric acid in blood. Jpn J Forensic Toxicol 21 (2003) 262-269
13. Elian A.A. Determination of endogenous gamma-hydroxybutyric acid (GHB) levels in antemortem urine and blood. Forensic Sci Int 128 (2002) 120-122
14. LeBeau M.A., Christenson R.H., Levine B., Darwin W.D., and Huestis M.A. Intra- and interindividual variations in urinary concentrations of endogenous gamma-hydroxybutyrate. J Anal Toxicol 26 (2002) 340-346
15. Elliott S.P. Gamma hydroxybutyric acid (GHB) concentrations in humans and factors affecting endogenous production. Forensic Sci Int 133 (2003) 9-16
16. Shima N., Miki A., Kamata T., Katagi M., and Tsuchihashi H. Urinary endogenous concentrations of GHB and its isomers in healthy humans and diabetics. Forensic Sci Int 149 (2005) 171-179
17. Snead III O.C., Brown G.B., and Morawetz R.B. Concentration of gamma-hydroxybutyric acid in ventricular and lumber cerebrospinal fluids. N Engl J Med 304 (1981) 93-95