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Volumn 122, Issue 10, 2009, Pages 1209-1213

Effect of ursodeoxycholic acid on TGF beta1/Smad signaling pathway in rat hepatic stellate cells

Author keywords

Hepatic stellate cells; Transforming growth factor beta1 Smad signaling pathway; Ursodeoxycholic acid

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MESSENGER RNA; SMAD PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; URSODEOXYCHOLIC ACID;

EID: 68249141226     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2009.10.018     Document Type: Article
Times cited : (26)

References (32)
  • 1
    • 34548416776 scopus 로고    scopus 로고
    • Mechanism of transforming growth factor beta/Smad signaling and the relationship between its transduction and liver fibrosis
    • Li YR, Wei L. Mechanism of transforming growth factor beta/Smad signaling and the relationship between its transduction and liver fibrosis. Chin J Hepatology (Chin) 2005; 6: 476-478.
    • (2005) Chin J Hepatology (Chin) , vol.6 , pp. 476-478
    • Li, Y.R.1    Wei, L.2
  • 5
    • 68249143706 scopus 로고    scopus 로고
    • Signal transduction of hepatic stellate cells in liver fibrosis
    • Liu X, Wei HS, Lin S. Signal transduction of hepatic stellate cells in liver fibrosis. J Med Mol Biol 2006; 5: 361-363.
    • (2006) J Med Mol Biol , vol.5 , pp. 361-363
    • Liu, X.1    Wei, H.S.2    Lin, S.3
  • 6
    • 13244249796 scopus 로고    scopus 로고
    • Identification of endoglin in rat hepatic stellate cells: New insights into transforming growth factor beta receptor signaling
    • Meurer SK, Tihaa L, Lahme B, Gressner AM, Weiskirchen R. Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling. J Biol Chem 2005; 280: 3078-3087.
    • (2005) J Biol Chem , vol.280 , pp. 3078-3087
    • Meurer, S.K.1    Tihaa, L.2    Lahme, B.3    Gressner, A.M.4    Weiskirchen, R.5
  • 7
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF beta receptor signaling and turnover
    • Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. Distinct endocytic pathways regulate TGF beta receptor signaling and turnover. Nat Cell Biol 2003; 5: 410-421.
    • (2003) Nat Cell Biol , vol.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4
  • 8
    • 0345304384 scopus 로고    scopus 로고
    • Parenchymal transforming growth factorβ1: Its type II receptor and Smad signaling pathway correlate with inflammation and fibrosis in chronic liver disease of viral etiology
    • Calabrese F, Valente M, Giaeometti C, Pettenazzo E, Benvegnu L, Alberti A, et al. Parenchymal transforming growth factorβ1: Its type II receptor and Smad signaling pathway correlate with inflammation and fibrosis in chronic liver disease of viral etiology. J Gastroenterol Hepatol 2003; 18: 1302-1308.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 1302-1308
    • Calabrese, F.1    Valente, M.2    Giaeometti, C.3    Pettenazzo, E.4    Benvegnu, L.5    Alberti, A.6
  • 9
    • 0036682952 scopus 로고    scopus 로고
    • Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control
    • Qin BY, Lam SS, Correia JJ, Lin K. Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control. Genes Dev 2002; 15: 1950-1963.
    • (2002) Genes Dev , vol.15 , pp. 1950-1963
    • Qin, B.Y.1    Lam, S.S.2    Correia, J.J.3    Lin, K.4
  • 10
    • 0142211206 scopus 로고    scopus 로고
    • Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import
    • Xu L, Alarcon C, Col S, Massague J. Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. J Biol Chem 2003; 43: 42569-42577.
    • (2003) J Biol Chem , vol.43 , pp. 42569-42577
    • Xu, L.1    Alarcon, C.2    Col, S.3    Massague, J.4
  • 11
    • 68249155742 scopus 로고    scopus 로고
    • The effect of exogenous Smad7 gene on activation of hepatic stellate cell in primary culture and its role in the regulation of geng expression
    • Chen YW, Chen YW, You HN, Li DG.. The effect of exogenous Smad7 gene on activation of hepatic stellate cell in primary culture and its role in the regulation of geng expression. Chin J Dig (Chin) 2005; 7: 409-421.
    • (2005) Chin J Dig (Chin) , vol.7 , pp. 409-421
    • Chen, Y.W.1    Chen, Y.W.2    You, H.N.3    Li, D.G.4
  • 12
    • 14944355361 scopus 로고    scopus 로고
    • Prognostic value of the expression of Smad6 and Smad7, as inhibitory Smads of the TGF-beta superfamily, in esophageal squamous cell carcinoma
    • Osawa H, Nakajima M, Kato H, Fukuchi M, Kuwano H. Prognostic value of the expression of Smad6 and Smad7, as inhibitory Smads of the TGF-beta superfamily, in esophageal squamous cell carcinoma. Anticancer Res 2004; 6: 3703-3709.
    • (2004) Anticancer Res , vol.6 , pp. 3703-3709
    • Osawa, H.1    Nakajima, M.2    Kato, H.3    Fukuchi, M.4    Kuwano, H.5
  • 13
    • 4544376914 scopus 로고    scopus 로고
    • Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2
    • Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, et al. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell 2004; 3: 251-261.
    • (2004) Cancer Cell , vol.3 , pp. 251-261
    • Wang, S.C.1    Lien, H.C.2    Xia, W.3    Chen, I.F.4    Lo, H.W.5    Wang, Z.6
  • 14
    • 34248548638 scopus 로고    scopus 로고
    • Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts
    • Jinnin M, Ihn H, Mimura Y, Mimura Y, Tamaki K. Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts. Arthritis Rheum 2007; 5: 1694-1705.
    • (2007) Arthritis Rheum , vol.5 , pp. 1694-1705
    • Jinnin, M.1    Ihn, H.2    Mimura, Y.3    Mimura, Y.4    Tamaki, K.5
  • 15
    • 1642338852 scopus 로고    scopus 로고
    • Mechanisms of action and therapeutic efficacy of ursodexycholic acid in cholestatic liver disease
    • Paumgartner G, Beuers U. Mechanisms of action and therapeutic efficacy of ursodexycholic acid in cholestatic liver disease. Clin Liver Dis 2004; 8: 67-81.
    • (2004) Clin Liver Dis , vol.8 , pp. 67-81
    • Paumgartner, G.1    Beuers, U.2
  • 16
    • 0043062632 scopus 로고    scopus 로고
    • Effects of ursodeoxycholic acid on intrahepatic cholestasis in rats
    • Li L, Xu X, Lu F, Zhao N. Effects of ursodeoxycholic acid on intrahepatic cholestasis in rats. Chin Med J 2003; 7: 1099-1103.
    • (2003) Chin Med J , vol.7 , pp. 1099-1103
    • Li, L.1    Xu, X.2    Lu, F.3    Zhao, N.4
  • 17
    • 21844466507 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis in fetal rat liver induced by maternal cholestasis. Protective effect of ursodeoxycholic acid
    • Perez MJ, Macias RI, Duran C, Monte MJ, Gonzalez-Buitrago JM, Marin JJ. Oxidative stress and apoptosis in fetal rat liver induced by maternal cholestasis. Protective effect of ursodeoxycholic acid. J Hepatol 2005; 2: 324-332.
    • (2005) J Hepatol , vol.2 , pp. 324-332
    • Perez, M.J.1    Macias, R.I.2    Duran, C.3    Monte, M.J.4    Gonzalez-Buitrago, J.M.5    Marin, J.J.6
  • 18
    • 14944361288 scopus 로고    scopus 로고
    • The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis
    • Corpechot C, Carrat F, Bahr A, Chrétien Y, Poupon RE, Poupon R. The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Gastroenterology 2005; 2: 297-303.
    • (2005) Gastroenterology , vol.2 , pp. 297-303
    • Corpechot, C.1    Carrat, F.2    Bahr, A.3    Chrétien, Y.4    Poupon, R.E.5    Poupon, R.6
  • 19
    • 0036927902 scopus 로고    scopus 로고
    • The influenec of sulinac on patients with primary biliary cirrhosis that responds inconmpletely to Ursodeoxycholic acid:a pilot study
    • Leuschner M, Holtmeier J, Achemann H, Leuschner U. The influenec of sulinac on patients with primary biliary cirrhosis that responds inconmpletely to Ursodeoxycholic acid:a pilot study. Eur J Gastrenterol Hepatol 2002; 12: 1369-1376.
    • (2002) Eur J Gastrenterol Hepatol , vol.12 , pp. 1369-1376
    • Leuschner, M.1    Holtmeier, J.2    Achemann, H.3    Leuschner, U.4
  • 21
    • 0036725044 scopus 로고    scopus 로고
    • Ursodeoxychlic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
    • Paumgartner G, Beuers U. Ursodeoxychlic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited. Hepatology 2002; 3: 525-531.
    • (2002) Hepatology , vol.3 , pp. 525-531
    • Paumgartner, G.1    Beuers, U.2
  • 22
    • 33744920572 scopus 로고    scopus 로고
    • Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis
    • Beuers U. Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis. Nat Clin Pract Gastroenterol Hepatol 2006; 6: 318-328.
    • (2006) Nat Clin Pract Gastroenterol Hepatol , vol.6 , pp. 318-328
    • Beuers, U.1
  • 24
    • 24644435870 scopus 로고    scopus 로고
    • Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis
    • Rust C, Beuers U. Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis. Clin Rev Allergy Immunol 2005; 2: 135-145.
    • (2005) Clin Rev Allergy Immunol , vol.2 , pp. 135-145
    • Rust, C.1    Beuers, U.2
  • 25
    • 68249145186 scopus 로고    scopus 로고
    • Relationship between different expressions of Smad3, Smad7 genes and liver fibrogenesis
    • Liang KH, Li Q, Wang Y, Tang WX, Zhang G, Wang TC. Relationship between different expressions of Smad3, Smad7 genes and liver fibrogenesis. Chin J Dig (Chin) 2002; 11: 647-650.
    • (2002) Chin J Dig (Chin) , vol.11 , pp. 647-650
    • Liang, K.H.1    Li, Q.2    Wang, Y.3    Tang, W.X.4    Zhang, G.5    Wang, T.C.6
  • 26
    • 2442539454 scopus 로고    scopus 로고
    • Expression of TGF1 and its receptors, Smad3 andSmad7 in rats with experimental liver fibrosis
    • Song S, Gong ZJ, Zhang QR. Expression of TGF1 and its receptors, Smad3 andSmad7 in rats with experimental liver fibrosis. World Chin J Digestol (Chin) 2004; 3: 676-679.
    • (2004) World Chin J Digestol (Chin) , vol.3 , pp. 676-679
    • Song, S.1    Gong, Z.J.2    Zhang, Q.R.3
  • 27
    • 24344500807 scopus 로고    scopus 로고
    • Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alphy-smooth muscle actin organization
    • Uemura M, Swenson ES, Gaca MD, Giordano FJ, Reiss M, Wells RG. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alphy-smooth muscle actin organization. Mol Biol Cell 2005; 16: 4214-4224.
    • (2005) Mol Biol Cell , vol.16 , pp. 4214-4224
    • Uemura, M.1    Swenson, E.S.2    Gaca, M.D.3    Giordano, F.J.4    Reiss, M.5    Wells, R.G.6
  • 28
    • 69949129525 scopus 로고    scopus 로고
    • Dynamic characteristics of SARA during liver fibrogenesis in rats
    • Tao YY, Cui HY, Liu CH. Dynamic characteristics of SARA during liver fibrogenesis in rats. Chin J Hepatology (Chin) 2006; 12: 909-913.
    • (2006) Chin J Hepatology (Chin) , vol.12 , pp. 909-913
    • Tao, Y.Y.1    Cui, H.Y.2    Liu, C.H.3
  • 29
    • 18244401140 scopus 로고    scopus 로고
    • Differential regulation of TGFβ signal in hepatic stellate cells between acute and chronic rat liver injury
    • Tahashi Y, Matsuzaki K, Date M, Yoshida K, Furukawa F, Sugano Y, et al. Differential regulation of TGFβ signal in hepatic stellate cells between acute and chronic rat liver injury. Hepatology 2002; 35: 49-61.
    • (2002) Hepatology , vol.35 , pp. 49-61
    • Tahashi, Y.1    Matsuzaki, K.2    Date, M.3    Yoshida, K.4    Furukawa, F.5    Sugano, Y.6
  • 30
    • 10744228283 scopus 로고    scopus 로고
    • Arkadia amplifies TGF beta super family signaling through degradation of Smad7
    • Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, et al. Arkadia amplifies TGF beta super family signaling through degradation of Smad7. EMBO J 2003; 24: 6458-6470.
    • (2003) EMBO J , vol.24 , pp. 6458-6470
    • Koinuma, D.1    Shinozaki, M.2    Komuro, A.3    Goto, K.4    Saitoh, M.5    Hanyu, A.6
  • 31
    • 0037283113 scopus 로고    scopus 로고
    • Smad expression of hepatic stellate cells in liver cirrhosis in vivo and hepatic stellate cell line in vitro
    • Kitamura Y, Ninomiya H. Smad expression of hepatic stellate cells in liver cirrhosis in vivo and hepatic stellate cell line in vitro. Pathol Int 2003; 53: 18-26.
    • (2003) Pathol Int , vol.53 , pp. 18-26
    • Kitamura, Y.1    Ninomiya, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.