Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese

BMC Gastroenterology

Volumn 9, Issue , 2009, Pages

  Hishida, Asahi ^a   Matsuo, Keitaro ^b   Goto, Yasuyuki ^a   Naito, Mariko ^a   Wakai, Kenji ^a   Tajima, Kazuo ^b   Hamajima, Nobuyuki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; GUANINE; IMMUNOGLOBULIN G ANTIBODY; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PEPSINOGEN; BACTERIUM ANTIBODY; PROTEIN TYROSINE PHOSPHATASE SHP 2; PTPN11 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER RISK; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HELICOBACTER INFECTION; HUMAN; INTRON; JAPANESE; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; STOMACH ATROPY; STOMACH CANCER; STOMACH DISEASE; ATROPHY; BLOOD; CASE CONTROL STUDY; ETHNOLOGY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; HELICOBACTER PYLORI; IMMUNOLOGY; JAPAN; MICROBIOLOGY; MIDDLE AGED; PATHOGENICITY; PATHOLOGY; RETROSPECTIVE STUDY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL MODEL; STOMACH; STOMACH TUMOR;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, BACTERIAL; ATROPHY; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INTRONS; JAPAN; LINKAGE DISEQUILIBRIUM; LOGISTIC MODELS; MALE; MIDDLE AGED; PEPSINOGENS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RETROSPECTIVE STUDIES; RISK FACTORS; STOMACH; STOMACH NEOPLASMS;

EID: 68249139901     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-9-51     Document Type: Article

References (45)

1. Blaser MJ Perez-Perez GI Kleanthous H Cover TL Peek RM Chyou PH Stemmermann GN Nomura A Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach Cancer Res 1995, 55:2111-5 7743510
2. Uemura N Okamoto S Yamamoto S Matsumura N Yamaguchi S Yamakido M Taniyama K Sasaki N Schlemper RJ Helicobacter pylori infection and the development of gastric cancer N Engl J Med 2001, 345:784-9 10.1056/ NEJMoa001999 11556297
3. El-Omar EM Rabkin CS Gammon MD Vaughan TL Risch HA Schoenberg JB Stanford JL Mayne ST Goedert J Blot WJ Fraumeni JF Jr Chow WH Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms Gastroenterology 2003, 124:1193-201 10.1016/ S0016-5085(03)00157-4 12730860
4. Machado JC Figueiredo C Canedo P Pharoah P Carvalho R Nabais S Alves CC Campos ML van Doorn LJ Caldas C Seruca R Carneiro F Sobrinho-Simões M A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma Gastroenterology 2003, 125:364-71 10.1016/S0016-5085(03)00899-0 12891537
5. Figueiredo C Machado JC Pharoah P Seruca R Sousa S Carvalho R Capelinha AF Quint W Caldas C van Doorn LJ Carneiro F Sobrinho-Simoes M Helicobacter pylori and interleukin 1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma J Natl Cancer Inst 2002, 94(22):1680-1687 12441323
6. Rad R Prinz C Neu B Neuhofer M Zeitner M Voland P Becker I Schepp W Gerhard M Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa J Infect Dis 2003, 15:272-81 10.1086/376458
7. Yamaoka Y El-Zimaity HMT Gutierrez O Gutierrez O Figura N Kim JK Kodama T Kashima K Graham DY Relationship between the cagA 3′ repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH Gastroenterol 1999, 117:342-9 10.1053/gast.1999.0029900342
8. Azuma T Yamazaki S Yamakawa A Ohtani M Muramatu A Suto H Ito Y Dojo M Yamazaki Y Kuriyama M Keida Y Higashi H Hatakeyama M Association between diversity in the src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer J Infect Dis 2004, 189:820-7 10.1086/381782 14976598
9. Asahi M Azuma T Ito S Ito Y Suto H Nagai Y Tsubokawa M Tohyama Y Maeda S Omata M Suzuki T Sasakawa C Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells J Exp Med 2000, 191:593-602 2195829 10684851 10.1084/jem.191.4.593
10. Higashi H Tsutsumi R Muto S Sugiyama T Azuma T Asaka M Hatakeyama M SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein Science 2002, 295:683-86 10.1126/science.1067147 11743164
11. Neel BG Gu H Pao L The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling Trends Biochem Sci 2003, 28:284-93 10.1016/S0968-0004(03)00091-4 12826400
12. Tartaglia M Niemeyer CM Shannon KM Loh ML SHP-2 and myeloid malignancies Curr Opin Hematol 2004, 11:44-50 10.1097/00062752-200401000-00007 14676626
13. Segal ED Cha J Lo J Falkow S Tompkins LS Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori Proc Natl Acad Sci USA 1999, 96:14559-64 24475 10588744 10.1073/pnas.96.25.14559
14. Hamajima N Rahimov B Malikov Y Abdiev S Ahn KS Bahramov S Kawai S Nishio K Naito M Goto Y Associations between a PTPN11 polymorphism and gastric atrophy - opposite in Uzbekistan to that in Japan Asian Pac J Cancer Prev 2008, 9:217-20 18712962
15. Hamajima N Naito M Kondo T Goto Y Genetic factors involved in the development of Helicobacter pylori-related gastric cancer Cancer Sci 2006, 97:1129-38 10.1111/j.1349-7006.2006.00290.x 16879717
16. Hamajima N Matsuo K Saito T Tajima K Okuma K Yamao K Tominaga S Interleukin 1 polymorphisms, lifestyle factors, and Helicobacter pylori infection Jpn J Cancer Res 2001, 92:383-9 11346459
17. Kato S Onda M Yamada S Matsuda N Tokunaga A Matsukura N Association of the interleukin-1β genetic polymorphism and gastric cancer risk in Japanese J Gastroenterol 2001, 36:696-9 10.1007/s005350170033 11686480
18. Hamajima N Shibata A Katsuda N Matsuo K Ito H Saito T Tajima K Tominaga S The highest Helicobacter pylori seropositive rate among those with TNF-A-857TT and -1031TT: Genotypes Gastric Cancer 2003, 6:230-6 10.1007/ s10120-003-0258-z 14716517
19. Goto Y Hamajima N Honda H Matsuo K Yamamoto K Tamakoshi A Ando T Goto H Association between Helicobacter pylori seropositivity and NAD(P)H quinone oxidoreductase 1 (NQO1) C609T polymorphism observed for outpatients and health checkup examinees Gastric Cancer 2005, 8:12-17 10.1007/s10120-004-0308-1 15747169
20. Goto Y Ando T Nishio K Kawai S Ishida Y Naito M Goto H Hamajima N Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy Int J Med Sci 2006, 4:1-6 1752235 17211494
21. Togawa S Joh T Itoh M Katsuda N Ito H Matsuo K Tajima K Hamajima N Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection Helicobacter 2005, 10:172-8 10.1111/j.1523-5378.2005.00308.x 15904474
22. Peleteiro B Lunet N Santos-Silva F David L Figueiredo C Barros H Short mucin 1 alleles are associated with low virulent H pylori strains infection World J Gastroenterol 2007, 13:1885-6 17465489
23. Kawakubo M Ito Y Okimura Y Kobayashi M Sakura K Kasama S Fukuda MN Fukuda M Katsuyama T Nakayama J Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection Science 2004, 305:1003-6 10.1126/science.1099250 15310903
24. Goto Y Ando T Yamamoto K Tamakoshi A El-Omar E Goto H Hamajima N Association between serum pepsinogens and polymorphism of PTPN11 encoding SHP-2 among Helicobacter pylori seropositive Japanese Int J Cancer 2006, 118:203-8 10.1002/ijc.21338 16032704
25. Kawai S Goto Y Ito LS Oba-Shinjo SM Uno M Shinjo SK Marie SK Ishida Y Nishio K Naito M Hamajima N Significant association between PTPN11 polymorphism and gastric atrophy among Japanese Brazilians Gastric Cancer 2006, 9:277-83 10.1007/s10120-006-0391-6 17235629
26. Jamshidi Y Gooljar SB Snieder H Wang X Ge D Swaminathan R Spector TD O'Dell SD SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women Atherosclerosis 2007, 194:e26-33 2084489 17214991 10.1016/j.atherosclerosis.2006.12.013
27. Tajima K Hirose K Inoue M Takezaki T Hamajima N Kuroishi T A Model of Practical Cancer Prevention for Out-patients Visiting a Hospital: The Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC) Asian Pac J Cancer Prev 2000, 1:35-47 12718687
28. Hamajima N Saito T Matsuo K Kozaki K Takahashi T Tajima K Polymerase chain reaction with confronting two-pair primers for polymorphism genotyping Jpn J Cancer Res 2000, 91:865-8 11011111
29. Higashi H Tsutsumi R Fujita A Yamazaki S Asaka M Azuma T Hatakeyama M Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites Proc Natl Acad Sci USA 2002, 99:14428-33 137900 12391297 10.1073/pnas.222375399
30. Hatakeyama M Helicobacter pylori CagA - a bacterial intruder conspiring gastric carcinogenesis Int J Cancer 2006, 119:1217-23 10.1002/ijc.21831 16557568
31. Mimuro H Suzuki T Tanaka J Asahi M Haas R Sasakawa C Grb2 is a key mediator of Helicobacter pylori CagA protein activities Mol Cell 2002, 10:745-55 10.1016/S1097-2765(02)00681-0 12419219
32. Churin Y Al-Ghoul L Kepp O Meyer TF Birchmeier W Naumann M Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response J Cell Biol 2003, 161:249-55 2172921 12719469 10.1083/ jcb.200208039
33. Tsutsumi R Higashi H Higuchi M Okada M Hatakeyama M Attenuation of Helicobacter pylori CagA × SHP-2 signaling by interaction between CagA and C-terminal Src kinase J Biol Chem 2003, 278:3664-70 10.1074/ jbc.M208155200 12446738
34. Amieva MR Vogelmann R Covacci A Tompkins LS Nelson WJ Falkow S Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA Science 2003, 300:1430-4 10.1126/science.1081919 12775840
35. Saadat I Higashi H Obuse C Umeda M Murata-Kamiya N Saito Y Lu H Ohnishi N Azuma T Suzuki A Ohno S Hatakeyama M Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity Nature 2007, 447:330-3 10.1038/nature05765 17507984
36. Ito Y Azuma T Ito S Miyaji H Hirai M Yamazaki Y Sato F Kato T Kohli Y Kuriyama M Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan J Clin Microbiol 1997, 35:1710-4 229827 9196179
37. Azuma T Helicobacter pylori CagA protein variation associated with gastric cancer in Asia J Gastroenterol 2004, 39:97-103 10.1007/ s00535-003-1279-4 15069615
38. Miki K Ichinose M Shimizu A Huang SC Oka H Furihata C Matsushima T Takahashi K Serum pepsinogens as a screening test of extensive chronic gastritis Gastroenterol Jpn 1987, 22:133-41 3596151
39. Biemond I Kreuning J Jansen JB Lamers CB Serum pepsinogens in patients with gastric diseases or after gastric surgery Scand J Gastroenterol 1994, 29:238-42 10.3109/00365529409090470 8209183
40. Oksanen A Sipponen P Miettinen A Sarna S Rautelin H Evaluation of blood tests to predict normal gastric mucosa Scand J Gastroenterol 2000, 35:791-5 10.1080/003655200750023138 10994615
41. Yanaoka K Oka M Mukoubayashi C Yoshimura N Enomoto S Iguchi M Magari H Utsunomiya H Tamai H Arii K Ohata H Fujishiro M Takeshita T Mohara O Ichinose M Cancer high-risk subjects identified by serum pepsinogen tests: Outcomes after 10-year follow-up in asymptomatic middle-aged males Cancer Epidemiol Biomarkers Prev 2008, 17:838-45 10.1158/ 1055-9965.EPI-07-2762 18398025
42. Inoue M Kobayashi S Matsuura A Hamajima N Tajima K Tominaga S Agreement of endoscopic findings and serum pepsinogen levels as an indicator of atrophic gastritis Cancer Epidemiol Biomarkers Prev 1998, 7:261-3 9521444
43. Suzuki H Hibi T Marshall BJ Helicobacter pylori: Present status and future prospects in Japan J Gastroenterol 2007, 42:1-15 10.1007/ s00535-006-1990-z 17322988
44. Sasazuki S Inoue M Iwasaki M Otani T Yamamoto S Ikeda S Hanaoka T Tsugane S Japan Public Health Center Study Group Effect of Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: A nested case-control study Cancer Epidemiol Biomarkers Prev 2006, 15:1341-7 10.1158/ 1055-9965.EPI-05-0901 16835334
45. Craanen ME Dekker W Blok P Ferwerda J Tytgat GN Intestinal metaplasia and Helicobacter pylori: An endoscopic bioptic study of the gastric antrum Gut 1992, 33:16-20 1373858 1740271 10.1136/gut.33.1.16