IL-10 and IL-12 are the main regulatory cytokines in visceral leishmaniasis

Cytokine

Volumn 12, Issue 8, 2000, Pages 1228-1231

  Bacellar, Olívia ^a   D'Oliveira Jr , Argemiro ^a   Jerônimo, Selma ^b   Carvalho, Edgar M ^a  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

Author keywords

Cytokines; Interleukin 10; Interleukin 12; Leishmaniasis; Visceral leishmaniasis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; PARASITE ANTIGEN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; LEISHMANIA CHAGASI; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; PRIORITY JOURNAL; VISCERAL LEISHMANIASIS;

LEISHMANIA DONOVANI CHAGASI; PROTOZOA;

EID: 0033859837     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2000.0694     Document Type: Article

References (24)

1. Murray HW, Rubin BY, Rothermel CD. Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocyte. Evidence that interferon gamma is the activating lymphokine. J Clin Invest. 72:1983;1506-1510.
2. Carvalho EM, Bacellar O, Reed SG, Barral A, Rocha H. Visceral leishmaniasis: a disease associated with inability of lymphocyte to activate macrophage to kill leishmania. Braz J Med Biol Res. 21:1988;85-92.
3. Farrel JP, Muller I, Louis JA. A role of Lyt-2 T cell in resistance to cutaneous leishmaniasis in immunized mice. J Immunol. 142:1989;2052-2056.
4. Carvalho EM, Badaró R, Reed SG, Jones TC, Johnson WD. Absence of gamma interferon and Interleukin-2 production during active visceral leishmaniasis. J Clin Invest. 76:1985;2066-2069.
5. Ghalib HW, Whittle JA, Kubin M, Hashim FA, El-Hassan AM. Interleukin-12 enhances Th1-type responses in human Leishmania donovani infections. J Immunol. 154:1995;4623-4629.
6. Carvalho EM, Bacellar O, Brownell C, Regis T, Coffman RL, Reed SG. Restoration of IFN-γ production and lymphocyte proliferation in visceral leishmaniasis. J Immunol. 152:1994;5949-5956.
7. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM. Reciprocal expression of IFN-γ or IL-4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med. 169:1989;59-72.
8. Wilson ME, Young BM, Davidson BL, Mente KA, McGowan SE. The importance of TGF-β in murine visceral leishmaniasis. J Immunol. 161:1998;6148-6155.
9. Barral-Netto M, Barral A, Brownell C, Skeiky YAW, Ellingsworth LR, Twardzik DR, Reed SG. Transforming growth factor beta in leishmanial infection: A parasite escape mechanism. Science. 257:1992;545-548.
10. Manetti R, Parronchi P, Giudizi MG, Piccinni M-P, Maggi E, Trinchieri G, Romagnani S. Natural killer cell stimulatory factor (Interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune response and inhibits the development of IL-4-producing Th cells. J Exp Med. 177:1993;1199-1204.
11. Bacellar O, Brodskyn C, Guerreiro J, Barral-Netto M, Costa CH. Interleukin-12 restores IFN-gamma production and cytotoxic responses in visceral leishmaniasis. J Infect Dis. 173:1996;1515-1518.
12. Carvalho EM, Teixeira RS, Johnson WD. Cell mediated immunity in American visceral leishmaniasis. Reversible immunosuppression during acute infection. Infect Immun. 22:1981;649-654.
13. Carvalho EM, Barral A, Pedral-Sampaio D, Barral-Netto M, Badaró R, Rocha H, Johnson WD Jr. Immunologic markers of clinical evolution in children recently infected with Leishmania donovani chagasi. J Infect Dis. 165:1992;535-540.
14. Assreuy, J, Cunha, FQ, Epperlein, M, Noronha-Dutra, A, O'Donnell, CA, Liew, FY, Moncada, S, 1994, Production of nitric oxide and superoxide by activated macrophages and killing of L. major, Eur J Immunol, 24, 672, 676.
15. Afonso LCC, Scharton TM, Vieira LQ, Wysocka M, Trinchieri G, Scott P. The adjuvant effect of IL-12 in a vaccine against L. major. Science. 263:1994;235-237.
16. Nabors GS, Afonso LCC, Farrel JP, Scott P. A switch from Th2 to Th1 type response and cure of established Leishmaina major infection in mice is induced by combined therapy with IL-12 and pentostam. Proc Natl Acad Sci USA. 92:1995;3142-3146.
17. Murray HW, Hariprashad J. Interleukin-12 is effective treatment for an established systemic intracellular infection: Experimental visceral leishmaniasis. J Exp Med. 181:1995;387-391.
18. Kemp M, Kurtzhals JAL, Bendtzen K, Poulsen LK, Hansen MB, Koech DK, Kharazmi A, Theander TG. Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis. Infect Immun. 61:1993;1069-1073.
19. Zwingenberger K, Harms G, Pedrosa C, Omena S, Sandkamp B, Neifer S. Determinants of the immune response in visceral leishmaniasis. Evidence for predominance of endogenous IL4 over IFN-gamma production. Clin Immunol Immunopathol. 54:1990;242-249.
20. Scott P, Eaton A, Gause WC, Zhou X, Hondowicz B. Early IL-4 production does not predict susceptibility to Leishmania major. Exp Parasitol. 84:1996;178-187.
21. Noben-Trauth N, Kropf P, Muller I. Susceptibility to Leishmania major infection in IL-4 deficient mice. Science. 271:1996;987-989.
22. Saha B, Das G, Vohra H, Ganguly NK, Mishra GC. Macrophage T cell interaction in experimental visceral leishmaniasis: failure to express co-stimulatory molecules onLeishmania -infected macrophages and its implication in the suppression of cell-mediated immunity. Eur J Immunol. 25:1995;2494-2498.
23. Ding L, Linsley PS, Huang L-Y, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol. 151:1993;1224-1234.
24. Kubin M, Kamoun M, Trinchieri G. Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J Exp Med. 180:1994;211-222.