Pharmacokinetics and the bystander effect in CD::UPRT/5-FC bi-gene therapy of glioma

Chinese Medical Journal

Volumn 122, Issue 11, 2009, Pages 1267-1272

  Shi, De Zhi ^a   Hu, Wei Xing ^a   Li, Li Xin ^a   Chen, Gong ^a   Wei, Dong ^a   Gu, Pei Yuan ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Bystander effect; Cytosine deaminase; Glioma; Magnetic resonance spectroscopy; Pharmacokinetics; Uracil phosphoribosyltransferase

Indexed keywords

CYTOSINE DEAMINASE; FLUCYTOSINE; FLUORINATED NUCLEOTIDE; FLUOROURACIL; ORGANOFLUORINE DERIVATIVE; UNCLASSIFIED DRUG; URACIL PHOSPHORIBOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BYSTANDER EFFECT; CANCER GENE THERAPY; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENTIATION; FEASIBILITY STUDY; FLUORINE NUCLEAR MAGNETIC RESONANCE; GENE DIRECTED ENZYME PRODRUG THERAPY; GENE EXPRESSION; GLIOMA; IMAGING AND DISPLAY; IN VITRO STUDY; IN VIVO STUDY; MALE; NON INVASIVE MEASUREMENT; NONHUMAN; OPTICAL IMAGING; RAT; SUICIDE GENE THERAPY; SURVIVAL RATE; TUMOR MODEL;

ANIMALS; ANTIMETABOLITES; CELL LINE; CYTOSINE DEAMINASE; FLUCYTOSINE; GENE THERAPY; GLIOMA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PENTOSYLTRANSFERASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 68249133577     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2009.11.006     Document Type: Article

References (31)

1. Ghosh SS, Takahashi M, Thummala NR, Parashar B, Chowdhury NR, Chowdhury JR. Liver-directed gene therapy: promises, problems and prospects at the turn of the century. J Hepatol 2000; 32 (1 Suppl): s238-s252.
2. Ghosh SS, Gopinath P, Ramesh A. Adenoviral vectors: a promising tool for gene therapy. Appl Biochem Biotechnol 2006; 133: 9-29.
3. Springer CJ, Niculescu-Duvaz I. Prodrug-activating systems in suicide gene therapy. J Clin Invest 2000; 105: 1161-1167.
4. El-Aneed A. Current strategies in cancer gene therapy. Eur J Pharmacol 2004; 498: 1-8.
5. Kurozumi K, Tamiya T, Ono Y, Otsuka S, Kambara H, Adachi Y, et al. Apoptosis induction with 5-fluorocytosine/cytosine deaminase gene therapy for human malignant glioma cells mediated by adenovirus. J Neurooncol 2004; 66: 117-127.
6. Richard C, Duivenvoorden W, Bourbeau D, Massie B, Roa W, Yau J. et al. Sensitivity of 5-fluorouracil-resistant cancer cells to adenovirus suicide gene therapy. Cancer Gene Ther 2007; 14: 57-65.
7. Kambara H, Tamiya T, Ono Y, Ohtsuka S, Terada K, Adachi Y. et al. Combined radiation and gene therapy for brain tumors with adenovirus-mediated transfer of cytosine deaminase and uracil phosphoribosyltransferase genes. Cancer Gene Ther 2002; 9: 840-845.
8. Chu RL, Post DE, Khuri FR, Van Meir EG. Use of replicating oncolytic adenoviruses in combination therapy for cancer. Clin Cancer Res 2004; 10: 5299-5312.
9. Crystal RG, Hirschowitz E, Lieberman M, Daly J, Kazam E, Henschke C. et al. Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine. Hum Gene Ther 1997; 8: 985-1001.
10. McSheehy PM, Griffiths JR. 19F MRS studies of fluoropyrimidine chemotherapy. NMR Biomed 1989; 2: 133-141.
11. Findlay M, Cunningham D, Norman A, Mansi J, Nicolson M, Hickish T, et al. A phase II study in advanced gastro-esophageal cancer using epirubicin and cisplatin in combination with continuous infusion 5-fluorouracil (ECF). Ann Oncol 1994; 5: 609-616.
12. Newell DR, Maxwell RJ, Golding BT. In vivo and ex vivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review. NMR Biomed 1992; 5: 273-278.
13. Hu WX, Feng LS, Lu C, Tang GX, Shi DZ, Jia XM, et al. Efficacy of 5-FC/ yeast CD::UPRT combined gene therapy for malignant glioma. Chin J Neurosurg (Chin) 2006; 22: 377-370.
14. Procissi D, Claus F, Burgman P, Koziorowski J, Chapman JD, Thakur SB, et al. In vivo 19F magnetic resonance spectroscopy and chemical shift imaging of tri-fluoro-nitroimidazole as a potential hypoxia reporter in solid tumors. Clin Cancer Res 2007; 13: 3738-3747.
15. Stegman LD, Rehemtulla A, Beattie B, Kievit E, Lawrence TS, Blasberg RG, et al. Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci U S A 1999; 96: 9821-9826.
16. Kievit E, Bershad E, Ng E, Sethna P, Dev I, Lawrence TS, et al. Superiority of yeast over bacterial cytosine deaminase for enzyme/ prodrug gene therapy in colon cancer xenografts. Cancer Res 1999; 59: 1417-1421.
17. Mullen CA, Kilstrup M, Blaese RM. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system. Proc Natl Acad Sci U S A 1992; 89: 33-37.
18. Mulligan RC. The basic science of gene therapy. Science 1993; 260: 926-932.
19. Anderes PS, Smith JM, Mygimd B. Characterization of the upp gene encoding uracil phosphoribosyltransferase of Escherichia coli K12. Eur J Biochem 1992; 204: 51-56.
20. Bogdanov A Jr, Weissleder R. The development of in vivo imaging systems to study gene expression. Trends Biotechnol 1998; 16: 5-10.
21. Deckers R, Quesson B, Arsaut J, Eimer S, Couillaud F, Moonen CT. Image-guided, noninvasive, spatiotemporal control of gene expression. Proc Natl Acad Sci U S A 2009; 106: 1175-1180.
22. Haberkorn U, Oberdorfer F, Gebert J, Morr I, Haack K, Weber K, et al. Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine. J Nucl Med 1996; 37: 87-94.
23. Corban-Wilhelm H, Hull WE, Becker G, Bauder-Wus U, Greulich D, Debus J. Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy. Gene Ther 2002; 9: 1564-1575.
24. Freeman SM, Ramesh R, Shastri M, Munshi A, Jensen AK, Marrogi AJ. The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells. Cancer Lett 1995; 92: 167-174.
25. Aghi M, Kramm CM, Chou TC, Breakefield XO, Chiocca EA. Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/ cytosine deaminase gene therapies. J Natl Cancer Inst 1998; 90: 370-380.
26. Kuriyama S, Mitoro A, Yamazaki M, Tsujinoue H, Nakatani T, Akahane T, et al. Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma. Scand J Gastroenterol 1999; 34: 1033-1041.
27. Paillard F. Suicide genes against brain tumors. Hum Gene Ther 1998; 9: 3-4.
28. Liu H, Hall WA, Martin AJ, Truwit CL. An efficient chemical shift imaging scheme for magnetic resonance-guided neurosurgery. J Magn Reson Imaging 2001; 14: 1-7.
29. Louie AY, Huber MM, Ahrens ET, Rothbacher U, Moats R, Jacobs RE, et al. In vivo visualization of gene expression using magnetic resonance imaging. Nat Biotechnol 2000; 18: 321-325.
30. Lei H. Magnetic Resonance Molecular Imaging Techniques. Chin J Magn Reson (Chin) 2003; 20: 173-185.
31. Prost RW. Magnetic resonance spectroscopy. Med Phys 2008; 35: 4530-4544.