Dealing with dangerous accidents: DNA double-strand breaks take centre stage: Symposium on Genome Instability and DNA Repair

EMBO Reports

Volumn 10, Issue 8, 2009, Pages 837-842

  Costanzo, Vincenzo ^a   Chaudhuri, Jayanta ^b   Fung, Jennifer C ^c   Moran, John V ^d  

^a London Research Institute   (United Kingdom)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMIS; BRCA1 PROTEIN; ENDONUCLEASE; EXONUCLEASE; GENE PRODUCT; KU ANTIGEN; MEIOTIC RECOMBINATION 11; RAG1 PROTEIN; RAG2 PROTEIN; UNCLASSIFIED DRUG; XPG LIKE ENDONUCLEASE; XRCC4 PROTEIN;

B LYMPHOCYTE; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; DNA HELIX; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; GENE EXPRESSION; GENE FUNCTION; GENE INSERTION; GENE LOCUS; GENE NUMBER; GENE REARRANGEMENT; GENE SWITCHING; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; HUMAN; MEIOSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL;

ANIMALS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; GENOMIC INSTABILITY; HUMANS; MODELS, BIOLOGICAL; SIGNAL TRANSDUCTION;

EID: 68249108667     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.173     Document Type: Conference Paper

References (24)

1. Brunet E, Simsek D, Tomishima M, DeKelver R, Choi VM, Gregory P, Urnov F, Weinstock DM, Jasin M (2009) Chromosomal translocations induced at specified loci in human stem cells. Proc Natl Acad Sci USA 106 10620-10625
2. Buis J, Wu Y, Deng Y, leddon J, Westfield G, Eckersdorff M, Sekiguchi JM, chang S, Ferguson DO (2008) Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 135: 85-96
3. Chaudhuri J et al (2007) Evolution of the immunoglobulin heavy chain class switch recombination mechanism. Adv Immunol 94: 157-214
4. Geisberger R, Rada C, Neuberger MS (2009) The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence. Proc Natl Acad Sci USA 106: 6736-6741
5. Grey C, Baudat F, de Massy B (2009) Genome-wide control of the distribution of meiotic recombination. PLoS Biol 7: 327-339
6. Huang Y, Giblin W, Kubec M, Westfield G, St Charles J, Chadde L, Kraftson S, Sekiguchi J (2009) Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability. J Exp Med 206: 893-908
7. Ip SC, Rass U, Blanco MG, Flynn HR, Skehel JM, West SC (2008) Identification of Holliday junction resolvases from humans and yeast. Nature 456: 357-361
8. Keeney S, Neale MJ (2006) Initiation of meiotic recombination by formation of DNA double-strand breaks: Mechanism and regulation. Biochem Soc Trans 34: 523-525
9. Lee JA, Carvalho CM, Lupski JR (2007) A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders. Cell 131: 1235-1247
10. Liu Y, West SC (2004) Happy Hollidays: 40th anniversary of the Holliday junction. Nat Rev Mol Cell Biol 5: 937-944
11. Lupski JR (2009) Genomic disorders ten years on. Genome Med 1 42
12. Mimitou EP, Symington LS (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770-774
13. Morgan HD, Dean W, Coker HA, Reik W, Petersen-Mahrt SK (2004) Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: Implications for epigenetic reprogramming. J Biol Chem 279: 52353-52360
14. Muramatsu M, Nagaoka H, Shinkura R, Begum NA, Honjo T (2007) Discovery of activation-induced cytidine deaminase, the engraver of antibody memory. Adv Immunol 94: 1-36
15. Parvanov ED, NG SH, Petkov PM, Paigen K (2009) Trans-regulation of mouse meiotic recombination hotspots by rcr1. PLoS Biol 7: 340-349
16. Ramiro A, San-Martin BR, McBride K, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC (2007) the role of activation-induced deaminase in antibody diversification and chromosome translocations. Adv Immunol 94: 75-107
17. Reid LJ, Shakya R, Modi AP, Lokshin M, Cheng JT, Jasin M, Baer R, Ludwig T (2008) E3 ligase activity of BRCA1 is not essential for cell viability of homology-directed repair of double-strand DNA breaks. Proc Natl Acad Sci USA 105: 20876-20881
18. Revy P, Buck D, le Deist F, de Villartay JP (2005) the repair of Dna damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models. Adv Immunol 87: 237-295
19. Robbiani DF et al (2008) AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell 135 1028-1038
20. Sekiguchi JM, Ferguson DO (2006) Dna double-strand break repair: A relentless hunt uncovers new prey. Cell 124: 260-262
21. Tsai AG, Lu H, Raghavan SC, Muschen M, Hsieh CL, Lieber MR (2008) Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell 135: 1130-1142
22. Wang B, Hurov K, Hofmann K, Elledge SJ (2009) NBa1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes Dev 23: 729-739
23. Weinstock DM, Brunet E, Jasin M (2007) Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70. Nat Cell Biol 9: 978-981
24. Zhu Z, Chung WH, Shim EY, Lee SE, Ira G (2008) Sgs1 helicase and two nucleases DNA2 and Exo1 resect DNA double-strand break-induced gene conversion. Cell 134: 981-994