Transcription factor AP-2β inhibits glucose-induced insulin secretion in cultured insulin-secreting cell-line

Diabetes Research and Clinical Practice

Volumn 85, Issue 3, 2009, Pages 279-285

  Tsukada, Shuichi ^a   Kobayashi, Masa aki ^a   Omori, Shintaro ^a   Unoki, Hiroyuki ^a   Maeda, Shiro ^a  

^a RIKEN   (Japan)

Author keywords

AP 2 ; Insulin secretion; Type 2 diabetes

Indexed keywords

BETA GALACTOSIDASE; GLUCOKINASE; GLUCOSE; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; POTASSIUM CHLORIDE; TOLBUTAMIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONTROLLED STUDY; DIABETOGENESIS; DISEASE COURSE; DISEASE PREDISPOSITION; EMBRYO; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT;

ANIMALS; CELL LINE; CRICETINAE; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE; HUMANS; INSULIN; ISLETS OF LANGERHANS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLBUTAMIDE; TRANSCRIPTION FACTOR AP-2;

EID: 68249106575     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2009.06.018     Document Type: Article

References (24)

1. International Diabetes federation (IDF), Diabetes Atlas, third edition (Available at http://www.eatlas.idf.org/).
2. Kahn B.B. Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 92 (1998) 593-596
3. Saltiel A.R. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104 (2001) 517-529
4. Maeda S., Tsukada S., Kanazawa A., Sekine A., Tsunoda T., Koya D., et al. Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J. Hum. Genet. 50 (2005) 283-292
5. Tsukada S., Tanaka Y., Maegawa H., Kashiwagi A., Kawamori R., and Maeda S. Intronic polymorphisms within TFAP2B regulate transcriptional activity and affect adipocytokine gene expression in differentiated adipocytes. Mol. Endocrinol. 20 (2006) 1104-1111
6. Satoda M., Zhao F., Diaz G.A., Burn J., Goodship J., Davidson H.R., et al. Mutations in TFAP2B cause Char syndrome, a familial form of pa tent ductus arteriosus. Nat. Genet. 25 (2000) 42-46
7. Tao Y., Maegawa H., Ugi S., Ikeda K., Nagai Y., Egawa K., et al. The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes. Endocrinology 147 (2006) 1685-1696
8. Ikeda K., Maegawa H., Ugi S., Tao Y., Nishio Y., Tsukada S., et al. Transcription factor activating enhancer-binding protein-2beta. A negative regulator of adiponectin gene expression. J. Biol. Chem. 281 (2006) 31245-31253
9. Santerre R.F., Cook R.A., Crisel R.M., Sharp J.D., Schmidt R.J., Williams D.C., et al. Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells. Proc. Natl. Acad. Sci. USA 78 (1981) 4339-4343
10. Moser M., Imhof A., Pscherer A., Bauer R., Amselgruber W., Sinowatz F., et al. Cloning and characterization of a second AP-2 transcription factor: AP-2 beta. Development 121 (1995) 2779-2788
11. Matschinsky F.M., Glaser B., and Magnuson M.A. Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes 47 (1998) 307-315
12. Meglasson M.D., and Matschinsky F.M. New perspectives on pancreatic islet glucokinase. Am. J. Physiol. 246 (1984) E1-13
13. Liang Y., Najafi H., Smith R.M., Zimmerman E.C., Magnuson M.A., Tal M., et al. Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes 41 (1992) 792-806
14. Wang H., and Iynedjian P.B. Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase. Proc. Natl. Acad. Sci. USA 94 (1997) 4372-4377
15. Postic C., Shiota M., and Magnuson M.A. Cell-specific roles of glucokinase in glucose homeostasis. Recent Prog. Horm. Res. 56 (2001) 195-217
16. Grupe A., Hultgren B., Ryan A., Ma Y.H., Bauer M., and Stewart T.A. Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell 83 (1995) 69-78
17. Bali D., Svetlanov A., Lee H.W., Fusco-DeMane D., Leiser M., Li B., et al. Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J. Biol. Chem. 270 (1995) 21464-21467
18. Terauchi Y., and Kadowaki T. Insights into molecular pathogenesis of type 2 diabetes from knockout mouse models. Endocr. J. 49 (2002) 247-263
19. Miki T., Nagashima K., Tashiro F., Kotake K., Yoshitomi H., Tamamoto A., et al. Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proc. Natl. Acad. Sci. USA 95 (1998) 10402-10406
20. Ashfield R., and Ashcroft S.J. Cloning of the promoters for the beta-cell ATP-sensitive K-channel subunits Kir6.2 and SUR1. Diabetes 47 (1998) 1274-1280
21. Yamagata K. Regulation of pancreatic beta-cell function by the HNF transcription network: lessons from maturity-onset diabetes of the young (MODY). Endocr. J. 50 (2003) 491-499
22. Cerf M.E. Transcription factors regulating beta-cell function. Eur. J. Endocrinol. 155 (2006) 671-679
23. Servitja J.M., and Ferrer J. Transcriptional networks controlling pancreatic development and beta cell function. Diabetologia 47 (2004) 597-613
24. Gupta R.K., Vatamaniuk M.Z., Lee C.S., Flaschen R.C., Fulmer J.T., Matschinsky F.M., et al. The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion. J. Clin. Invest. 115 (2005) 1006-1015