Preload responsiveness is associated with increased interleukin-6 and lower organ yield from brain-dead donors

Critical Care Medicine

Volumn 37, Issue 8, 2009, Pages 2387-2393

  Murugan, Raghavan ^a   Venkataraman, Ramesh ^a   Wahed, Abdus S ^b   Elder, Michele ^a   Carter, Melinda ^a   Madden, Nicholas J ^a   Kellum, John A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Brain dead organ donors; Cytokine; Inflammation; Interleukin 6; Organ transplantation; Pulse pressure variation

Indexed keywords

INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BRAIN DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART PRELOAD; HEMODYNAMIC MONITORING; HEMODYNAMICS; HUMAN; INFLAMMATION; INTENSIVE CARE UNIT; MALE; ORGAN DONOR; ORGAN TRANSPLANTATION; PILOT STUDY; PRIORITY JOURNAL; PULSE PRESSURE; RESUSCITATION;

EID: 68249101553     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181a960d6     Document Type: Article

References (21)

1. United Network for Organ Sharing: United States facts about transplantation, Richmond, VA. http://www.optn.org/latestData/ step2.asp.? Accessed December 7, 2008
2. Murugan R, Venkataraman R, Wahed AS, et al: Increased plasma interleukin-6 in donors is associated with lower recipient hospitalfree survival after cadaveric organ transplantation. Crit Care Med 2008; 36:1810-1816
3. Pratschke J, Wilhelm MJ, Kusaka M, et al: Brain death and its influence on donor organ quality and outcome after transplantation. Transplantation 1999; 67:343-348
4. Herijgers P, Leunens V, Tjandra-Maga TB, et al: Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines. Transplantation 1996; 62: 330-335
5. Richards PS, Nelson KA, Frazier OH, et al: Why referred potential heart donors aren't used. Tex Heart Inst J 1993; 20:218-222
6. Weiss S, Kotsch K, Francuski M, et al: Brain death activates donor organs and is associated with a worse I/R injury after liver transplantation. Am J Transplant 2007; 7:1584-1593
7. Wilhelm MJ, Pratschke J, Beato F, et al: Activation of the heart by donor brain death accelerates acute rejection after transplantation. Circulation 2000; 102:2426-2433
8. Birks EJ, Burton PB, Owen V, et al: Elevated tumor necrosis factor-alpha and interleukin-6 in myocardium and serum of malfunctioning donor hearts. Circulation 2000; 102: III352-III358
9. Torre-Amione G, Kapadia S, Benedict C, et al: Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 1996; 27:1201-1206
10. Salim A, Velmahos GC, Brown C, et al: Aggressive organ donor management signifi-cantly increases the number of organs available for transplantation. J Trauma 2005; 58: 991-994
11. Kumar A, Anel R, Bunnell E, et al: Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects. Crit Care Med 2004; 32:691-699
12. Osman D, Ridel C, Ray P, et al: Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challenge. Crit Care Med 2007; 35:64-68
13. Michard F, Teboul JL. Using heart-lung interactions to assess fluid responsiveness during mechanical ventilation. Crit Care 2000; 4:282-289
14. LiDCOplus, Cambridge, UK. http://www.lidco. com. Accessed December 7, 2008
15. Michard F, Boussat S, Chemla D, et al: Relation between respiratory changes in arterial pulse pressure and fluid responsiveness in septic patients with acute circulatory failure. Am J Respir Crit Care Med 2000; 162: 134-138
16. Tavernier B, Makhotine O, Lebuffe G, et al: Systolic pressure variation as a guide to fluid therapy in patients with sepsis-induced hypotension. Anesthesiology 1998; 89:1313-1321
17. Lopes MR, Oliveira MA, Pereira VO, et al: Goal-directed fluid management based on pulse pressure variation monitoring during high-risk surgery: a pilot randomized controlled trial. Crit Care 2007; 11:R100
18. Sander M, Spies CD, Berger K, et al: Prediction of volume response under open-chest conditions during coronary artery bypass surgery. Crit Care 2007; 11:R121
19. Hofer CK, Muller SM, Furrer L, et al: Stroke volume and pulse pressure variation for prediction of fluid responsiveness in patients undergoing off-pump coronary artery bypass grafting. Chest 2005; 128:848-854
20. Clarke CJ, Hales A, Hunt A, et al: IL-10-mediated suppression of TNF-alpha production is independent of its ability to inhibit NF kappa B activity. Eur J Immunol 1998; 28: 1719-1726
21. Wang P, Wu P, Siegel MI, et al: Interleukin (IL)-10 inhibits nuclear factor kappa B (NF kappa B) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem 1995; 270:9558-9563