-
1
-
-
1842530296
-
Causes and prevalence of visual impairment among adults in the United States
-
The Eye Diseases Prevalence Research Group
-
The Eye Diseases Prevalence Research Group. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 2004, 122(4): 477-485
-
(2004)
Arch Ophthalmol
, vol.122
, Issue.4
, pp. 477-485
-
-
-
2
-
-
33845519530
-
The economic burden of major adult visual disorders in the United States
-
DOI 10.1001/archopht.124.12.1754
-
Rein, D.B., Zhang, P., Wirth, K.E. et al. The economic burden of major adult visual disorders in the United States. Arch Ophthalmol 2006, 124(12): 1754-1760 (Pubitemid 44920172)
-
(2006)
Archives of Ophthalmology
, vol.124
, Issue.12
, pp. 1754-1760
-
-
Rein, D.B.1
Zhang, P.2
Wirth, K.E.3
Lee, P.P.4
Hoerger, T.J.5
McCall, N.6
Klein, R.7
Tielsch, J.M.8
Vijan, S.9
Saaddine, J.10
-
3
-
-
0027370108
-
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
-
The Diabetes Control and Complications Trial Research Group
-
The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993, 329(14): 977-986
-
(1993)
N Engl J Med
, vol.329
, Issue.14
, pp. 977-986
-
-
-
4
-
-
0032511583
-
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
-
UK Prospective Diabetes Study Group
-
UK Prospective Diabetes Study Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352(9131): 837-853
-
(1998)
Lancet
, vol.352
, Issue.9131
, pp. 837-853
-
-
-
5
-
-
0022347471
-
Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 1
-
Early Treatment Diabetic Retinopathy Study Research Group
-
Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema. Early Treatment Diabetic Retinopathy Study Report Number 1. Arch Ophthalmol 1985, 103(12): 1796-1806
-
(1985)
Arch Ophthalmol
, vol.103
, Issue.12
, pp. 1796-1806
-
-
-
6
-
-
0019473351
-
Photocoagulation treatment of proliferative diabetic retinopathy. Clinical application of Diabetic Retinopathy Study (DRS) findings, DRS Report Number 8
-
The Diabetic Retinopathy Study Research Group
-
The Diabetic Retinopathy Study Research Group. Photocoagulation treatment of proliferative diabetic retinopathy. Clinical application of Diabetic Retinopathy Study (DRS) findings, DRS Report Number 8. Ophthalmology 1981, 88(7): 583-600.
-
(1981)
Ophthalmology
, vol.88
, Issue.7
, pp. 583-600
-
-
-
7
-
-
34547869213
-
Pharmacotherapies for diabetic retinopathy: Present and future
-
article ID 52487.
-
Schwartz, S.G., Flynn Jr., H.W. Pharmacotherapies for diabetic retinopathy: Present and future. Exp Diabetes Res 2007, 2007: article ID 52487.
-
(2007)
Exp Diabetes Res
, vol.2007
-
-
Schwartz, S.G.1
Flynn Jr., H.W.2
-
8
-
-
0036240895
-
Intravitreal triamcinolone for refractory diabetic macular edema
-
DOI 10.1016/S0161-6420(02)00975-2, PII S0161642002009752
-
Martidis, A., Duker, J.S., Greenberg, P.B., Rogers, A.H., Puliafito, C.A., Reichel, E., Baumal, C. Intravitreal triamcinolone for refractory diabetic macular edema. Ophthalmology 2002, 109(5): 920-927 (Pubitemid 34465226)
-
(2002)
Ophthalmology
, vol.109
, Issue.5
, pp. 920-927
-
-
Martidis, A.1
Duker, J.S.2
Greenberg, P.B.3
Rogers, A.H.4
Puliafito, C.A.5
Reichel, E.6
Baumal, C.7
-
9
-
-
33947275043
-
Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema
-
DOI 10.1001/archopht.125.3.309
-
Kuppermann, B.D., Blumenkranz, M.S., Haller, J.A. et al. Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema. Arch Ophthalmol 2007, 125(3): 309-317 (Pubitemid 46425557)
-
(2007)
Archives of Ophthalmology
, vol.125
, Issue.3
, pp. 309-317
-
-
Kuppermann, B.D.1
Blumenkranz, M.S.2
Haller, J.A.3
Williams, G.A.4
Weinberg, D.V.5
Chou, C.6
Whitcup, S.M.7
-
10
-
-
26844520874
-
Pooled efficacy results from two multinational randomized controlled clinical trials of a single intravitreous injection of highly purified ovine hyaluronidase (Vitrase®) for the management of vitreous hemorrhage
-
Vitrase for Vitreous Hemorrhage Study Groups
-
Kuppermann, B.D, Thomas, E.L., de Smet, M.D., Grillone, L.R.; Vitrase for Vitreous Hemorrhage Study Groups. Pooled efficacy results from two multinational randomized controlled clinical trials of a single intravitreous injection of highly purified ovine hyaluronidase (Vitrase®) for the management of vitreous hemorrhage. Am J Ophthalmol 2005, 140(4): 573-584
-
(2005)
Am J Ophthalmol
, vol.140
, Issue.4
, pp. 573-584
-
-
Kuppermann, B.D.1
Thomas, E.L.2
De Smet, M.D.3
Grillone, L.R.4
-
11
-
-
25844513658
-
A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema
-
Cunningham Jr., E.T., Adamis, A.P., Altaweel, M. et al. A phase II randomized double-masked trial of pegaptanib, an anti-vascular endothelial growth factor aptamer, for diabetic macular edema. Ophthalmology 2005, 112(10): 1747-1757
-
(2005)
Ophthalmology
, vol.112
, Issue.10
, pp. 1747-1757
-
-
Cunningham Jr., E.T.1
Adamis, A.P.2
Altaweel, M.3
-
12
-
-
33646464279
-
Intravitreal bevacizumab (Avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage
-
DOI 10.1097/00006982-200603000-00004, PII 0000698220060300000004
-
Spaide, R.F., Fisher, Y.L. Intravitreal bevacizumab (Avastin) treatment of proliferative diabetic retinopathy complicated by vitreous hemorrhage. Retina 2006, 26(3): 275-278 (Pubitemid 44318179)
-
(2006)
Retina
, vol.26
, Issue.3
, pp. 275-278
-
-
Spaide, R.F.1
Fisher, Y.L.2
-
13
-
-
33748957021
-
A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema
-
Chun, D.W., Heier, J.S., Topping, T.M., Duker, J.S., Bankert, J.M. A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema. Ophthalmology 2006, 113(10): 1706-1712
-
(2006)
Ophthalmology
, vol.113
, Issue.10
, pp. 1706-1712
-
-
Chun, D.W.1
Heier, J.S.2
Topping, T.M.3
Duker, J.S.4
Bankert, J.M.5
-
14
-
-
33947499863
-
Pharmacological treatment of diabetic retinopathy
-
DOI 10.1159/000098256
-
Lang, G.E. Pharmacological treatment of diabetic retinopathy. Ophthalmologic 2007, 221(2): 112-117 (Pubitemid 46465436)
-
(2007)
Ophthalmologica
, vol.221
, Issue.2
, pp. 112-117
-
-
Lang, G.E.1
-
15
-
-
0036939182
-
The potential role of PKC β in diabetic retinopathy and macular edema
-
Aiello, L.P. The potential role of PKC β in diabetic retinopathy and macular edema. Surv Ophthalmol 2002, 47(Suppl. 2): S263-9.
-
(2002)
Surv Ophthalmol
, vol.47
, Issue.SUPPL. 2
-
-
Aiello, L.P.1
-
16
-
-
0346494560
-
Protein kinase C inhibition and diabetic retinopathy: A shot in the dark at translational research
-
DOI 10.1136/bjo.88.1.145
-
Donnelly, R., Idris, I., Forrester, J.V. Protein kinase C inhibition and diabetic retinopathy: A shot in the dark at translational research. Br J Ophthalmol 2004, 88(1): 145-151 (Pubitemid 38091382)
-
(2004)
British Journal of Ophthalmology
, vol.88
, Issue.1
, pp. 145-151
-
-
Donnelly, R.1
Idris, I.2
Forrester, J.V.3
-
17
-
-
0032104245
-
The extended protein kinase C superfamily
-
Mellor, H., Parker, P.J. The extended protein kinase C superfamily. Biochem J 1998, 332(Pt. 2):281-292. (Pubitemid 28271856)
-
(1998)
Biochemical Journal
, vol.332
, Issue.2
, pp. 281-292
-
-
Mellor, H.1
Parker, P.J.2
-
18
-
-
36549002610
-
PKC inhibition and diabetic microvascular complications
-
DOI 10.1016/j.beem.2007.09.007, PII S1521690X07000917, New Therapies for Diabetes
-
Clarke, M., Dodson, P.M. PKC inhibition and diabetic microvascular complications. Best Pract Res Clin Endocrinol Metab 2007, 21(4): 573-586 (Pubitemid 350177570)
-
(2007)
Best Practice and Research in Clinical Endocrinology and Metabolism
, vol.21
, Issue.4
, pp. 573-586
-
-
Clarke, M.1
Dodson, P.M.2
-
19
-
-
0036716566
-
Prospects for kinase activity modulators in the treatment of diabetes and diabetic complications
-
Bullock W.H., Magnuson, S.R., Choi, S., Gunn, D.E., Rudolph, J. Prospects for kinase activity modulators in the treatment of diabetes and diabetic complications. Curr Top Med Chem 2002, 2(9): 915-938
-
(2002)
Curr Top Med Chem
, vol.2
, Issue.9
, pp. 915-938
-
-
Bullock, W.H.1
Magnuson, S.R.2
Choi, S.3
Gunn, D.E.4
Rudolph, J.5
-
20
-
-
0037184495
-
Molecular understanding of hyperglycemia's adverse effects for diabetic complications
-
Sheetz, M.J., King, G.L. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA 2002, 288(20): 2579-2588
-
(2002)
JAMA
, vol.288
, Issue.20
, pp. 2579-2588
-
-
Sheetz, M.J.1
King, G.L.2
-
21
-
-
0345346385
-
Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo
-
DOI 10.2337/diabetes.48.6.1316
-
Ceolotto, G., Gallo, A., Miola, M. et al. Protein kinase C activity is acutely regulated by plasma glucose concentration in human monocytes in vivo. Diabetes 1999, 48(6): 1316-1322 (Pubitemid 29241032)
-
(1999)
Diabetes
, vol.48
, Issue.6
, pp. 1316-1322
-
-
Ceolotto, G.1
Gallo, A.2
Miola, M.3
Sartori, M.4
Trevisan, R.5
Del Prato, S.6
Semplicini, A.7
Avogaro, A.8
-
23
-
-
0033621019
-
Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells
-
Li, P.F., Maasch, C., Haller, H., Dietz, R., von Harsdorf, R. Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells. Circulation 1999, 100(9): 967-973 (Pubitemid 29407178)
-
(1999)
Circulation
, vol.100
, Issue.9
, pp. 967-973
-
-
Li, P.-F.1
Maasch, C.2
Haller, H.3
Dietz, R.4
Von Harsdorf, R.5
-
24
-
-
0038642030
-
Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes
-
Pomero, F., Allione, A., Betramo, E. et al. Effects of protein kinase C inhibition and activation on proliferation and apoptosis of bovine retinal pericytes. Diabetologia 2003, 46(3): 416-419 (Pubitemid 36547598)
-
(2003)
Diabetologia
, vol.46
, Issue.3
, pp. 416-419
-
-
Pomero, F.1
Allione, A.2
Beltramo, E.3
Buttiglieri, S.4
D'Alu, F.5
Ponte, E.6
Lacaria, A.7
Porta, M.8
-
25
-
-
0030863502
-
Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro
-
Williams, B., Gallacher, B., Patel, H., Orme, C. Glucose-induced protein kinase C activation regulates vascular permeability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro. Diabetes 1997, 46(9): 1497-1503 (Pubitemid 27369089)
-
(1997)
Diabetes
, vol.46
, Issue.9
, pp. 1497-1503
-
-
Williams, B.1
Gallacher, B.2
Patel, H.3
Orme, C.4
-
26
-
-
0033949316
-
Induction of endothelin-1 expression by glucose an effect of protein kinase C activation
-
Park, J.Y., Takahara, N., Gabriele, A. et al. Induction of endothelin-1 expression by glucose: An effect of protein kinase C activation. Diabetes 2000, 49(7): 1239-1248 (Pubitemid 30439101)
-
(2000)
Diabetes
, vol.49
, Issue.7
, pp. 1239-1248
-
-
Park, J.-Y.1
Takahara, N.2
Gabriele, A.3
Chou, E.4
Naruse, K.5
Suzuma, K.6
Yamauchi, T.7
Ha, S.-W.8
Meier, M.9
Rhodes, C.J.10
King, G.L.11
-
27
-
-
0034434874
-
High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent
-
Park, C.W., Kim, J.H., Lee, J.H. et al. High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent. Diabetologia 2000, 43(12): 1544-1553
-
(2000)
Diabetologia
, vol.43
, Issue.12
, pp. 1544-1553
-
-
Park, C.W.1
Kim, J.H.2
Lee, J.H.3
-
28
-
-
0028850578
-
Protein kinase C in diabetic nephropathy
-
Craven, P.A., Studer, R.K., Negrete, H., DeRubertis, F.R. Protein kinase C in diabetic nephropathy. J Diabetes Complications 1995, 9(4): 241-245
-
(1995)
J Diabetes Complications
, vol.9
, Issue.4
, pp. 241-245
-
-
Craven, P.A.1
Studer, R.K.2
Negrete, H.3
Derubertis, F.R.4
-
29
-
-
8944246315
-
(S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16 21-dimetheno-1H,13H-diebenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene- 1,3(2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase C beta
-
Jirousek, M.R., Gillig, J.R., Gonzalez, C.M. et al. (S)-13- [(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16 21-dimetheno-1H,13H- diebenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase C beta. J Med Chem 1996, 39(14): 2664-2671
-
(1996)
J Med Chem
, vol.39
, Issue.14
, pp. 2664-2671
-
-
Jirousek, M.R.1
Gillig, J.R.2
Gonzalez, C.M.3
-
30
-
-
34248180118
-
Ruboxistaurin: LY 333531
-
No authors listed
-
[No authors listed]. Ruboxistaurin: LY 333531. Drugs R D 2007, 8(3): 193-199
-
(2007)
Drugs R D
, vol.8
, Issue.3
, pp. 193-199
-
-
-
31
-
-
0034607382
-
Salt form selection and characterization of LY333531 mesylate monohydrate
-
Engel, G.L., Farid, N.A., Faul, M.M., Richardson, L.A., Winneroski, L.L. Salt form selection and characterization of LY333531 mesylate monohydrate. Int J Pharm 2000, 198(2), 239-247
-
(2000)
Int J Pharm
, vol.198
, Issue.2
, pp. 239-247
-
-
Engel, G.L.1
Farid, N.A.2
Faul, M.M.3
Richardson, L.A.4
Winneroski, L.L.5
-
32
-
-
0037154156
-
Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization
-
DOI 10.1073/pnas.022644499
-
Suzuma, K., Takahara, N., Suzuma, I. et al. Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A 2002, 99(2): 721-726 (Pubitemid 34106577)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.2
, pp. 721-726
-
-
Suzuma, K.1
Takahara, N.2
Suzuma, I.3
Isshiki, K.4
Ueki, K.5
Leitges, M.6
Aiello, L.P.7
King, G.L.8
-
33
-
-
2642709170
-
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
-
Xia, P., Aiello, L.P., Ishii, H. et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 1996, 98(9): 2018-2026 (Pubitemid 26376289)
-
(1996)
Journal of Clinical Investigation
, vol.98
, Issue.9
, pp. 2018-2026
-
-
Xia, P.1
Aiello, L.P.2
Ishii, H.3
Jiang, Z.Y.4
Park, D.J.5
Robinson, G.S.6
Takagi, H.7
Newsome, W.P.8
Jirousek, M.R.9
King, G.L.10
-
34
-
-
13344293711
-
Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor
-
Ishii, H., Jirousek, M.R., Koya, D. et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β-inhibitor. Science 1996, 272(5262): 728-731 (Pubitemid 26000279)
-
(1996)
Science
, vol.272
, Issue.5262
, pp. 728-731
-
-
Ishii, H.1
Jirousek, M.R.2
Koya, D.3
Takagi, C.4
Xia, P.5
Clermont, A.6
Bursell, S.-E.7
Kern, T.S.8
Ballas, L.M.9
Heath, W.F.10
Stramm, L.E.11
Feener, E.P.12
King, G.L.13
-
35
-
-
15644366961
-
Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor
-
Aiello, L.P., Bursell, S.E., Clermont, A. et al. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor. Diabetes 1997, 46(9): 1473-1480 (Pubitemid 27369086)
-
(1997)
Diabetes
, vol.46
, Issue.9
, pp. 1473-1480
-
-
Aiello, L.P.1
Bursell, S.-E.2
Clermont, A.3
Duh, E.4
Ishii, H.5
Takagi, C.6
Mori, F.7
Ciulla, T.A.8
Ways, K.9
Jirousek, M.10
Smith, L.E.H.11
King, G.L.12
-
36
-
-
0033868806
-
PKC-β inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats
-
Nonaka, A., Kiryu, J., Tsujikawa, A. et al. PKC-β inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats. Invest Ophthalmol Vis Sci 2000, 41(9): 2702-2706 (Pubitemid 30624402)
-
(2000)
Investigative Ophthalmology and Visual Science
, vol.41
, Issue.9
, pp. 2702-2706
-
-
Nonaka, A.1
Kiryu, J.2
Tsujikawa, A.3
Yamashiro, K.4
Miyamoto, K.5
Nishiwaki, H.6
Honda, Y.7
Ogura, Y.8
-
37
-
-
1842855296
-
Blood-retinal barrier breakdown induced by activation of protein kinase C via vascular endothelial growth factor in streptozotocin-induced diabetic rats
-
DOI 10.1076/ceyr.28.4.251.27834
-
Xu, X., Zhu, Q., Xia, X., Zhang, S., Gu, Q., Luo, D. Blood-retinal barrier breakdown induced by activation of protein kinase C via vascular endothelial growth factor in streptozocin-induced diabetic rats. Curr Eye Res 2004, 28(4): 251-256 (Pubitemid 38491318)
-
(2004)
Current Eye Research
, vol.28
, Issue.4
, pp. 251-256
-
-
Xu, X.1
Zhu, Q.2
Xia, X.3
Zhang, S.4
Gu, Q.5
Luo, D.6
-
38
-
-
0031964664
-
Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKCβ inhibition with LY333531
-
Danis, R.P., Bingaman, D.P., Jirousek, M., Yang, Y. Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKCβ inhibition with LY333531. Invest Ophthalmol Vis Sci 1998, 39(1): 171-179 (Pubitemid 28040476)
-
(1998)
Investigative Ophthalmology and Visual Science
, vol.39
, Issue.1
, pp. 171-179
-
-
Danish, R.P.1
Bingaman, D.P.2
Jirousek, M.3
Yang, Y.4
-
39
-
-
33751089351
-
Disposition of [14C] ruboxistaurin in humans
-
Burkey, J.L., Campanale, K.M., Barbuch, R., O'Bannon, D., Rash, J., Benson, C., Small, D. Disposition of [14C] ruboxistaurin in humans. Drug Metab Dispos 2006, 34(11): 1909-17.
-
(2006)
Drug Metab Dispos
, vol.34
, Issue.11
, pp. 1909-1917
-
-
Burkey, J.L.1
Campanale, K.M.2
Barbuch, R.3
O'Bannon, D.4
Rash, J.5
Benson, C.6
Small, D.7
-
40
-
-
33644657206
-
Effects of chronic renal failure on the pharmacokinetics of ruboxistaurin and its active metabolite 338522
-
DOI 10.2165/00003088-200645030-00005
-
Wise, S., Yuen, E., Chan, C., Poo, Y.K., Teng, L., Lau, T., Voelker, J. Effects of chronic renal failure on the pharmacokinetics of ruboxistaurin and its active metabolite 338522. Clin Pharmacokinet 2006, 45(3): 297-303. (Pubitemid 43327494)
-
(2006)
Clinical Pharmacokinetics
, vol.45
, Issue.3
, pp. 297-303
-
-
Wise, S.1
Yuen, E.2
Chan, C.3
Yeo, K.P.4
Teng, L.5
Lau, T.6
Voelker, J.7
-
41
-
-
0037059549
-
Inhibition of protein kinase Cβ prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans
-
Beckman, J.A., Goldfine, A.B., Gordon, M.B., Garrett, L.A., Creager, M.A. Inhibition of protein kinase Cβ prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans. Circ Res 2002, 90(1): 107-111
-
(2002)
Circ Res
, vol.90
, Issue.1
, pp. 107-111
-
-
Beckman, J.A.1
Goldfine, A.B.2
Gordon, M.B.3
Garrett, L.A.4
Creager, M.A.5
-
42
-
-
33750549683
-
Clinical safety of the selective PKC-β inhibitor, ruboxistaurin
-
McGill, J.B., King, G.L., Berg, P.H., Price, K.L., Kles, K. A., Bastyr, E.J., Hyslop, D.L. Clinical safety of the selective PKC-β inhibitor, ruboxistaurin. Expert Opin Drug Saf 2006, 5(6): 835-845
-
(2006)
Expert Opin Drug Saf
, vol.5
, Issue.6
, pp. 835-845
-
-
McGill, J.B.1
King, G.L.2
Berg, P.H.3
Price, K.L.4
Kles, K.A.5
Bastyr, E.J.6
Hyslop, D.L.7
-
43
-
-
21344435254
-
The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: Initial results of the protein kinase C β inhibitor diabetic retinopathy study (PKC-DRS) multicenter randomized clinical trial
-
The PKC-DRS Study Group
-
The PKC-DRS Study Group. The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: Initial results of the protein kinase C β inhibitor diabetic retinopathy study (PKC-DRS) multicenter randomized clinical trial. Diabetes 2005, 54(7): 2188-2197
-
(2005)
Diabetes
, vol.54
, Issue.7
, pp. 2188-2197
-
-
-
44
-
-
33751520614
-
Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy
-
PKC-DRS2 Group
-
PKC-DRS2 Group, Aiello, L.P., Davis, M.D. et al. Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy. Ophthalmology 2006, 113(12): 2221-2230
-
(2006)
Ophthalmology
, vol.113
, Issue.12
, pp. 2221-2230
-
-
Aiello, L.P.1
Davis, M.D.2
-
45
-
-
33947236725
-
Effect of ruboxistaurin in patients with diabetic macular edema: Thirty-month results of the randomized PKC-DMES clinical trial
-
The PKC-DMES Study Group
-
The PKC-DMES Study Group. Effect of ruboxistaurin in patients with diabetic macular edema: Thirty-month results of the randomized PKC-DMES clinical trial. Arch Ophthalmol 2007, 125(3): 318-324
-
(2007)
Arch Ophthalmol
, vol.125
, Issue.3
, pp. 318-324
-
-
-
46
-
-
32944465911
-
Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema
-
DOI 10.1167/iovs.05-0096
-
Strøm, C., Sander, B., Klemp, K., Aiello, L.P., Lund-Anderson, H., Larsen, M. Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema. Invest Ophthalmol Vis Sci 2005, 46(10): 3855-3858 (Pubitemid 44264697)
-
(2005)
Investigative Ophthalmology and Visual Science
, vol.46
, Issue.10
, pp. 3855-3858
-
-
Strom, C.1
Sander, B.2
Klemp, K.3
Aiello, L.P.4
Lund-Andersen, H.5
Larsen, M.6
-
47
-
-
35148851469
-
Progression of diabetic macular edema: Correlation with blood-retinal barrier permeability, retinal thickness, and retinal vessel diameter
-
DOI 10.1167/iovs.06-1102
-
Sander, B., Thornit, D.N., Colmorn, L. et al Progression of diabetic macular edema: Correlation with blood-retinal barrier permeability, retinal thickness, and retinal vascular diameter. Invest Ophthalmol Vis Sci 2007, 48(9): 3983-3987 (Pubitemid 351261018)
-
(2007)
Investigative Ophthalmology and Visual Science
, vol.48
, Issue.9
, pp. 3983-3987
-
-
Sander, B.1
Thornit, D.N.2
Colmorn, L.3
Strom, C.4
Girach, A.5
Hubbard, L.D.6
Lund-Andersen, H.7
Larsen, M.8
-
48
-
-
33644842187
-
Inhibition of PKC β by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients
-
DOI 10.1167/iovs.05-0757
-
Aiello, L.P., Clermont, A., Arora, V., Davis, M.D., Sheetz, M.J., Bursell, S.E. Inhibition of PKC β by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients. Invest Ophthalmol Vis Sci 2006, 47(1): 86-92. (Pubitemid 46780799)
-
(2006)
Investigative Ophthalmology and Visual Science
, vol.47
, Issue.1
, pp. 86-92
-
-
Aiello, L.P.1
Clermont, A.2
Arora, V.3
Davis, M.D.4
Sheetz, M.J.5
Bursell, S.-E.6
-
49
-
-
84878706305
-
Longer treatment duration with ruboxistaurin (RBX) is associated with less visual acuity decline over a 6-year period despite cessation and reinstitution of therapy - Results of an open-label extension of the Protein Kinase C-Diabetic Retinopathy Study 2 (PKC-DRS2)
-
E-Abstract 4330
-
Sheetz, M.J., Aiello, L.P., Shahri, N. et al. Longer treatment duration with ruboxistaurin (RBX) is associated with less visual acuity decline over a 6-year period despite cessation and reinstitution of therapy - Results of an open-label extension of the Protein Kinase C-Diabetic Retinopathy Study 2 (PKC-DRS2). Invest Ophthalmol Vis Sci 2009, 50: E-Abstract 4330.
-
(2009)
Invest Ophthalmol Vis Sci
, vol.50
-
-
Sheetz, M.J.1
Aiello, L.P.2
Shahri, N.3
-
50
-
-
0028875360
-
Quantitative assessment of macular edema with optical coherence tomography
-
Hee, M.R., Puliafito, C.A., Wong, C. et al. Quantitative assessment of macular edema with optical coherence tomography. Arch Ophthalmol 1995, 113(8): 1019-1029
-
(1995)
Arch Ophthalmol
, vol.113
, Issue.8
, pp. 1019-1029
-
-
Hee, M.R.1
Puliafito, C.A.2
Wong, C.3
-
51
-
-
59449103833
-
Comparison of optical coherence tomography retinal thickness measurements in diabetic macular edema with and without reading center manual grading from a clinical trials perspective
-
Diabetic Retinopathy Clinical Research Network Study Group
-
Glassman, A.R., Beck, R.W., Browning, D.J., Danis, R.P., Kollman, C.; Diabetic Retinopathy Clinical Research Network Study Group. Comparison of optical coherence tomography retinal thickness measurements in diabetic macular edema with and without reading center manual grading from a clinical trials perspective. Invest Ophthalmol Vis Sci 2008, 50(2): 560-566
-
(2008)
Invest Ophthalmol Vis Sci
, vol.50
, Issue.2
, pp. 560-566
-
-
Glassman, A.R.1
Beck, R.W.2
Browning, D.J.3
Danis, R.P.4
Kollman, C.5
|