Indomethacin overcomes doxorubicin resistance by decreasing intracellular content of glutathione and its conjugates with decreasing expression of γ-glutamylcysteine synthetase via promoter activity in doxorubicin-resistant leukemia cells

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 4, 2009, Pages 715-721

  Asano, Takeshi ^a   Tsutsuda Asano, Arisa ^a   Fukunaga, Yoshitaka ^a  

^a NIPPON MEDICAL SCHOOL CHIBA HOKUSOH HOSPITAL   (Japan)

Author keywords

Glutamylcysteine synthetase; Doxorubicin resistant; Glutathione; Indomethacin; K562; MRP1; Promoter

Indexed keywords

DOXORUBICIN; ETOPOSIDE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; INDOMETACIN; VINCRISTINE;

ARTICLE; CANCER RESISTANCE; CELL STRAIN K 562; CYTOTOXICITY; DRUG POTENTIATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; DNA PRIMERS; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; INDOMETHACIN; K562 CELLS; LEUKEMIA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

EID: 68149175259     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0920-6     Document Type: Article

References (24)

1. T Asano C-L Zhi J Hayakawa Y Fukunaga 2003 Analysis of resistance-related gene expression in doxorubicin resistant leukemia cell line by DNA microarray Jpn J Pediatr Hematol 17 348 353
2. CA Brenner AW Tam PA Nelson EG Engleman N Suzuki KE Fry JW Larrick 1989 Message amplification phenotyping (MAPPing): a technique to simultaneously measure multiple mRNAs from small numbers of cells Bio techniques 7 1096 1103
3. KV Cullen RA Davey MW Davey 2001 Verapamil-stimulated glutathione transport by the mutidrug resistance-associated protein (MRP1) in leukaemia cells Biochem Pharmacol 62 417 424
4. B van der Holt B Lowenberg AK Burnett WU Knauf J Shepherd PP Piccaluga GJ Ossenkoppele GEG Verhoef A Ferrant M Crump D Selleslag M Theobald MF Fey E Vellenga M Dugan P Sonneveld on behalf of the Dutch-Belgian Hemato-Oncology Cooperative Group and the United Kingdom Medical Council. 2005 The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis Blood 106 2646 2654
5. T Iida H Kijima Y Urata S Goto Y Ihara M Ola S Kohno KJ Scanlon T Kondo 2001 Hammerhead ribozyne against γ-glutamylcysteine synthetase sensitizes human colon cancer cells to cisplatin by downregulating both the glutathione synthesis and the expression of multiple drug resistance protein Cancer Gene Ther 8 803 814
6. T Ishiwaka CD Wright H Ishizuka 1994 GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum(II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation J Biol Chem 269 29085 29093
7. T Ishikawa J-J Bao Y Yamane K Akimaru K Frindrich CD Wright MT Kuo 1996 Coordinated induction of MRP/GS-X pump and γ-glutamylcysteine synthetase by heavy metals in human leukemia cells J Biol Chem 271 14981 14988 (Pubitemid 26197576)
8. N Kartner JR Riordan V Ling 1985 Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines Science 316 820 823
9. DM van der Kolk EGE de Vries M Muller E Vellenga 2002 The role of drug efflux pumps in acute myeloid leukemia Leuk Lymphoma 43 685 701
10. N Kundu AM Fulton 2002 Selective cyclooxygenase (Cox)-1 or Cox-2 inhibitors control metastatic disease in a murine model of breast cancer Cancer Res 62 2343 2346
11. GD Kruth MG Belinsky 2003 The MRP family of drug efflux pumps Oncogene 22 7537 7552
12. MT Kuo J-J Bao SA Curley M Ikeguchi DA Johnston T Ishikawa 1996 Frequent coordinated overexpression of the MRP/GS-X pump and γ-glutamylcysteine synthetase genes in human colorectal cancers Cancer Res 56 3642 3644 (Pubitemid 26272004)
13. F Martin M-F Pener F Malergue H Lepidi A Dessein F Galland M de Reggi P Naquet B Gharib 2004 Vanin-1-/- mice show decreased NSAID- and Schistosoma-induced intestinal inflammation associated with higher glutathione stores J Clin Invest 113 591 597
14. S Matsunaga T Asano A Tsutsuda-Asano Y Fukunaga 2006 Indomethacin overcomes doxorubicin resistance with inhibiting Multi-drug resistance protein 1 (MRP1) Cancer Chemother Pharmacol 58 3 348 353
15. A Morales M Miranda A Sanchez-Reyes A Colell A Biete JC Fernandez-Checa 1998 Transcriptional regulation of eavy subunit chain of γ-glutamycysteine synthetase by ionizing radiation FEBS Lett 447 15 20
16. 4 or estradiol-17 (β-d-glucuronate) Biochem Pharmacol 70 1056 1065
17. A Roller O Baehr J Streffer S Winter M Heneka M Deininger R Meyermann U Naumann E Gulbins M Weller 1999 Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: the role of Cox-1 and MRP Biochem Biophys Res Commun 259 600 605
18. M Salerno A Garnier-Sullerot 2001 Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells Eur J Pharmacol 421 1 9
19. KJ Sales AA Katz B Howard RP Soeter RP Millar HN Jabbour RP Soeters 2002 Cyclooxygenase-1 is up-regulated in cervical carcinomas: Autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin E receptors, and angiogenic factors by cyclooxygenase-1 Cancer Res 62 424 432
20. J Sedlak RH Lindsay 1968 Estimation of total, protein-bound, and non-protein sulfhydryl groups in tissue with Ellman's reagent Ana Bioch 25 192 205
21. Y Takamura N Fatman E Kubo DP Singh 2006 Regulation of heavy subunit chain of γ-glutamylcysteine synthetase by tumor necrosis factor-α in lens epitherial cells: role of LEDGF/p75 Am J Physiol Cell Physiol 290 C554 C566
22. CHM Versantvoort HJ Broxterman T Bagrij RJ Scheper P Twentyman 1995 Regulation by glutathione of drug transport in multidrug-resistance-associated protein Brit J Cancer 72 82 89
23. K-S Yao AK Godwin SW Johnson RF Ozols PJ O'Dwyer TC Hamilton 1995 Evidence for altered regulation of γ-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines Cancer Res 55 4367 4374
24. H Zhi J Zhang G Hu J Lu X Wang C Zhou M Wu Z Liu 2003 The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma Int J Cancer 106 327 333