Analysis of a functional serotonin transporter promoter polymorphism in psoriasis vulgaris

Archives of Dermatological Research

Volumn 301, Issue 6, 2009, Pages 443-447

  Mössner, Rotraut ^a   Stiens, Gerthild ^b   König, Inke R ^c   Schmidt, Diane ^a   Platzer, Anja ^a   Krüger, Ullrich ^a   Reich, Kristian ^d  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Rheinische Kliniken Bonn   (Germany)

^c UNIVERSITY OF LÜBECK   (Germany)

^d DERMATOLOGIKUM HAMBURG   (Germany)

Author keywords

5 HTTLPR; Depression; Genetics; Psoriasis; Serotonin

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DEPRESSION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAMILTON SCALE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PSORIASIS VULGARIS;

ADULT; CASE-CONTROL STUDIES; DEPRESSION; DISEASE PROGRESSION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PSORIASIS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEVERITY OF ILLNESS INDEX;

EID: 68149150496     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-008-0909-3     Document Type: Article

References (25)

1. A Akay A Pekcanlar KE Bozdag L Altintas A Karaman 2002 Assessment of depression in subjects with psoriasis vulgaris and lichen planus J Eur Acad Dermatol Venereol 16 347 352 10.1046/j.1468-3083.2002.00467.x
2. L Beretta M Cossu M Marchini F Cappiello A Artoni G Motta R Scorza 2008 A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation Arthritis Res Ther 10 R103 10.1186/ar2495
3. AM Bowcock JG Krueger 2005 Getting under the skin: the immunogenetics of psoriasis Nat Rev Immunol 5 699 711 10.1038/nri1689
4. A Caspi K Sugden TE Moffitt A Taylor IW Craig H Harrington J McClay J Mill J Martin A Braithwaite R Poulton 2003 Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene Science 301 386 389 10.1126/science.1083968
5. S Eddahibi M Humbert E Fadel B Raffestin M Darmon F Capron G Simonneau P Dartevelle M Hamon S Adnot 2001 Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension J Clin Invest 108 1141 1150 (Pubitemid 32995372)
6. Essmann W (1978) Serotonin distribution in tissue and fluids. In: WB Essmann (ed) Serotonin in health and disease, vol 1. Spectrum, New York
7. A Heils A Teufel S Petri G Stober P Riederer D Bengel KP Lesch 1996 Allelic variation of human serotonin transporter gene expression J Neurochem 66 2621 2624 (Pubitemid 26159101)
8. M Idzko E Panther C Stratz T Muller H Bayer G Zissel T Durk S Sorichter F Di Virgilio M Geissler B Fiebich Y Herouy P Elsner J Norgauer D Ferrari 2004 The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release J Immunol 172 6011 6019 (Pubitemid 38621202)
9. NM Kushnir-Sukhov AM Gilfillan JW Coleman JM Brown S Bruening M Toth DD Metcalfe 2006 5-hydroxytryptamine induces mast cell adhesion and migration J Immunol 177 6422 6432 (Pubitemid 44628861)
10. KP Lesch R Mössner 1998 Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders? Biol Psychiatry 44 179 192 10.1016/S0006-3223(98) 00121-8
11. D Li L He 2007 Meta-analysis supports association between serotonin transporter (5-HTT) and suicidal behavior Mol Psychiatry 12 47 54 10.1038/sj.mp.4001890
12. M Marziniak R Mossner A Schmitt KP Lesch C Sommer 2005 A functional serotonin transporter gene polymorphism is associated with migraine with aura Neurology 64 157 159 10.1159/000088791
13. SA Miller DD Dykes HF Polesky 1988 A simple salting out procedure for extracting DNA from human nucleated cells Nucleic Acids Res 16 1215 10.1093/nar/16.3.1215
14. R Mössner A Henneberg A Schmitt YV Syagailo M Grassle T Hennig R Simantov M Gerlach P Riederer KP Lesch 2001 Allelic variation of serotonin transporter expression is associated with depression in Parkinson's disease Mol Psychiatry 6 350 352 10.1038/sj.mp.4000849
15. R Mössner KP Lesch 1998 Role of serotonin in the immune system and in neuroimmune interactions Brain Behav Immun 12 249 271 10.1006/brbi.1998.0532
16. RP Nair A Ruether PE Stuart S Jenisch T Tejasvi R Hiremagalore S Schreiber D Kabelitz HW Lim JJ Voorhees E Christophers JT Elder M Weichenthal 2008 Polymorphisms of the IL12B and IL23R genes are associated with psoriasis J Invest Dermatol 128 1653 1661 10.1038/sj.jid.5701255
17. PJ O'Connell X Wang M Leon-Ponte C Griffiths SC Pingle GP Ahern 2006 A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T-cells Blood 107 1010 1017 10.1182/blood-2005-07-2903
18. A Picardi E Mazzotti P Pasquini 2006 Prevalence and correlates of suicidal ideation among patients with skin disease J Am Acad Dermatol 54 420 426 10.1016/j.jaad.2005.11.1103
19. CL Raison L Capuron AH Miller 2006 Cytokines sing the blues: inflammation and the pathogenesis of depression Trends Immunol 27 24 31 10.1016/j.it.2005. 11.006
20. K Reich R Mössner IR König G Westphal A Ziegler C Neumann 2002 Promoter polymorphisms of the genes encoding tumor necrosis factor-alpha and interleukin-1 beta are associated with different subtypes of psoriasis characterized by early and late disease onset J Invest Dermatol 118 155 163 10.1046/j.0022-202x.2001.01642.x
21. JM Schmitt DE Ford 2007 Role of depression in quality of life for patients with psoriasis Dermatology 215 17 27 10.1159/000102029
22. N Thierry M Willeit N Praschak-Rieder P Zill K Hornik A Neumeister E Lenzinger J Stastny E Hilger A Konstantinidis H Aschauer M Ackenheil B Bondy S Kasper 2004 Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls Eur Neuropsychopharmacol 14 53 58 10.1016/S0924-977X(03)00064-6
23. S Tyring A Gottlieb K Papp K Gordon C Leonardi A Wang D Lalla M Woolley A Jahreis R Zitnik D Cella R Krishnan 2006 Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial Lancet 367 29 35 10.1016/S0140-6736(05)67763-X
24. S Wellek 2004 Tests for establishing compatibility of an observed genotype distribution with Hardy-Weinberg equilibrium in the case of a biallelic locus Biometrics 60 694 703 10.1111/j.0006-341X.2004.00219.x
25. S Zammit MJ Owen 2006 Stressful life events, 5-HTT genotype and risk of depression Br J Psychiatry 188 199 201 10.1192/bjp.bp.105.020644