Association between the rs2004640 functional polymorphism of interferon regulatory factor 5 and systemic lupus erythematosus: A meta-analysis

Rheumatology International

Volumn 29, Issue 10, 2009, Pages 1137-1142

  Lee, Young Ho ^a   Song, Gwan Gyu ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

IRF5; Meta analysis; Polymorphism; Systemic lupus erythematosus

Indexed keywords

INTERFERON REGULATORY FACTOR 5;

AFRICAN AMERICAN; ALLELE; ARTICLE; ASIAN; CAUCASIAN; DISEASE ASSOCIATION; GENE FREQUENCY; GENETIC POLYMORPHISM; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; PREVALENCE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

ALLELES; ASIA; ASIAN CONTINENTAL ANCESTRY GROUP; ETHNIC GROUPS; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERFERON REGULATORY FACTORS; LUPUS ERYTHEMATOSUS, SYSTEMIC; POLYMORPHISM, GENETIC; PREVALENCE;

EID: 68149137024     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-008-0801-7     Document Type: Article

References (28)

1. JB Harley JA Kelly KM Kaufman 2006 Unraveling the genetics of systemic lupus erythematosus Springer Semin Immunopathol 28 119 130 10.1007/s00281-006- 0040-5 (Pubitemid 44526313)
2. J Banchereau V Pascual 2006 Type I interferon in systemic lupus erythematosus and other autoimmune diseases Immunity 25 383 392 10.1016/j.immuni.2006.08.010 (Pubitemid 44354221)
3. T Taniguchi K Ogasawara A Takaoka N Tanaka 2001 IRF family of transcription factors as regulators of host defense Annu Rev Immunol 19 623 655 10.1146/annurev.immunol.19.1.623 (Pubitemid 32368048)
4. A Kawasaki C Kyogoku J Ohashi R Miyashita K Hikami M Kusaoi K Tokunaga Y Takasaki H Hashimoto TW Behrens N Tsuchiya 2008 Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphisms Arthritis Rheum 58 826 834 10.1002/art.23216
5. S Sigurdsson HH Goring G Kristjansdottir L Milani G Nordmark JK Sandling ML Eloranta D Feng N Sangster-Guity I Gunnarsson E Svenungsson G Sturfelt A Jonsen L Truedsson BJ Barnes G Alm L Ronnblom AC Syvanen 2008 Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus Hum Mol Genet 17 872 881 10.1093/hmg/ddm359
6. MV Reddy R Velazquez-Cruz V Baca G Lima J Granados L Orozco ME Alarcon-Riquelme 2007 Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans Hum Genet 121 721 727 10.1007/s00439-007-0367-6 (Pubitemid 46916971)
7. FY Demirci S Manzi R Ramsey-Goldman RL Minster M Kenney PS Shaw CM Dunlop-Thomas AH Kao E Rhew F Bontempo C Kammerer MI Kamboh 2007 Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE) Ann Hum Genet 71 308 311 10.1111/j.1469-1809. 2006.00336.x (Pubitemid 46585673)
8. RR Graham SV Kozyrev EC Baechler MV Reddy RM Plenge JW Bauer WA Ortmann T Koeuth MF Gonzalez Escribano B Pons-Estel M Petri M Daly PK Gregersen J Martin D Altshuler TW Behrens ME Alarcon-Riquelme 2006 A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus Nat Genet 38 550 555 10.1038/ng1782
9. S Sigurdsson G Nordmark HH Goring K Lindroos AC Wiman G Sturfelt A Jonsen S Rantapaa-Dahlqvist B Moller J Kere S Koskenmies E Widen ML Eloranta H Julkunen H Kristjansdottir K Steinsson G Alm L Ronnblom AC Syvanen 2005 Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus Am J Hum Genet 76 528 537 10.1086/428480 (Pubitemid 40250533)
10. HD Shin YK Sung CB Choi SO Lee HW Lee SC Bae 2007 Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population Arthritis Res Ther 9 R32 10.1186/ar2152 (Pubitemid 46680795)
11. JA Kelly JM Kelley KM Kaufman J Kilpatrick GR Bruner JT Merrill JA James SG Frank E Reams EE Brown AW Gibson MC Marion CD Langefeld QZ Li DR Karp EK Wakeland M Petri R Ramsey-Goldman JD Reveille LM Vila GS Alarcon RP Kimberly JB Harley JC Edberg 2008 Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans Genes Immun 9 187 194 10.1038/gene.2008.4 (Pubitemid 351584185)
12. HO Siu W Yang CS Lau TM Chan RW Wong WH Wong YL Lau ME Alarcon-Riquelme 2008 Association of a haplotype of IRF5 gene with systemic lupus erythematosus in Chinese J Rheumatol 35 360 362
13. M Egger G Davey Smith M Schneider C Minder 1997 Bias in meta-analysis detected by a simple, graphical test BMJ 315 629 634
14. JP Higgins SG Thompson 2002 Quantifying heterogeneity in a meta-analysis Stat Med 21 1539 1558 10.1002/sim.1186 (Pubitemid 34746062)
15. M Egger GD Smith AN Phillips 1997 Meta-analysis: principles and procedures BMJ 315 1533 1537
16. JB Harley ME Alarcon-Riquelme LA Criswell CO Jacob RP Kimberly KL Moser BP Tsao TJ Vyse CD Langefeld SK Nath JM Guthridge BL Cobb DB Mirel MC Marion AH Williams J Divers W Wang SG Frank B Namjou SB Gabriel AT Lee PK Gregersen TW Behrens KE Taylor M Fernando R Zidovetzki PM Gaffney JC Edberg JD Rioux JO Ojwang JA James JT Merrill GS Gilkeson MF Seldin H Yin EC Baechler QZ Li EK Wakeland GR Bruner KM Kaufman JA Kelly 2008 Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci Nat Genet 40 204 210 10.1038/ng.81 (Pubitemid 351171405)
17. I Ferreiro-Neira M Calaza E Alonso-Perez M Marchini R Scorza GD Sebastiani FJ Blanco I Rego R Pullmann Jr R Pullmann CG Kallenberg M Bijl FN Skopouli M Mavromati S Migliaresi N Barizzone S Ruzickova C Dostal RE Schmidt T Witte C Papasteriades I Kappou-Rigatou E Endreffy A Kovacs J Ordi-Ros E Balada P Carreira JJ Gomez-Reino A Gonzalez 2007 Opposed independent effects and epistasis in the complex association of IRF5 to SLE Genes Immun 8 429 438 10.1038/sj.gene.6364407 (Pubitemid 47177133)
18. SV Kozyrev S Lewen PM Reddy B Pons-Estel T Witte P Junker H Laustrup C Gutierrez A Suarez M Francisca Gonzalez-Escribano J Martin ME Alarcon-Riquelme 2007 Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus Arthritis Rheum 56 1234 1241 10.1002/art.22497 (Pubitemid 46608648)
19. RR Graham C Kyogoku S Sigurdsson IA Vlasova LR Davies EC Baechler RM Plenge T Koeuth WA Ortmann G Hom JW Bauer C Gillett N Burtt DS Cunninghame Graham R Onofrio M Petri I Gunnarsson E Svenungsson L Ronnblom G Nordmark PK Gregersen K Moser PM Gaffney LA Criswell TJ Vyse AC Syvanen PR Bohjanen MJ Daly TW Behrens D Altshuler 2007 Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus Proc Natl Acad Sci USA 104 6758 6763 10.1073/pnas.0701266104 (Pubitemid 47175574)
20. CO Jacob A Reiff DL Armstrong BL Myones E Silverman M Klein-Gitelman D McCurdy L Wagner-Weiner JJ Nocton A Solomon R Zidovetzki 2007 Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform Arthritis Rheum 56 4164 4173 10.1002/art.23060 (Pubitemid 350262344)
21. DS Cunninghame Graham H Manku S Wagner J Reid K Timms A Gutin JS Lanchbury TJ Vyse 2007 Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation Hum Mol Genet 16 579 591 10.1093/hmg/ddl469 (Pubitemid 46585660)
22. YH Lee SK Nath 2005 Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis Hum Genet 118 434 443 10.1007/s00439-005- 0073-1 (Pubitemid 43091214)
23. G Hom RR Graham B Modrek KE Taylor W Ortmann S Garnier AT Lee SA Chung RC Ferreira PV Pant DG Ballinger R Kosoy FY Demirci MI Kamboh AH Kao C Tian I Gunnarsson AA Bengtsson S Rantapaa-Dahlqvist M Petri S Manzi MF Seldin L Ronnblom AC Syvanen LA Criswell PK Gregersen TW Behrens 2008 Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX N Engl J Med 358 900 909 10.1056/NEJMoa0707865
24. K Honda H Yanai A Takaoka T Taniguchi 2005 Regulation of the type I IFN induction: a current view Int Immunol 17 1367 1378 10.1093/intimm/dxh318 (Pubitemid 41631313)
25. A Takaoka H Yanai S Kondo G Duncan H Negishi T Mizutani S Kano K Honda Y Ohba TW Mak T Taniguchi 2005 Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors Nature 434 243 249 10.1038/nature03308 (Pubitemid 40388058)
26. E Tackey PE Lipsky GG Illei 2004 Rationale for interleukin-6 blockade in systemic lupus erythematosus Lupus 13 339 343 10.1191/0961203304lu1023oa (Pubitemid 38788493)
27. SV Kozyrev ME Alarcon-Riquelme 2007 The genetics and biology of Irf5-mediated signaling in lupus Autoimmunity 40 591 601 10.1080/ 08916930701510905 (Pubitemid 350302184)
28. ME Mancl G Hu N Sangster-Guity SL Olshalsky K Hoops P Fitzgerald-Bocarsly PM Pitha K Pinder BJ Barnes 2005 Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function J Biol Chem 280 21078 21090 10.1074/jbc.M500543200 (Pubitemid 40805667)