Domain-structured N1,N2-derivatized hydrazines as inhibitors of ribonucleoside diphosphate reductase: Redox-cycling considerations

Journal of Medicinal Chemistry

Volumn 42, Issue 2, 1999, Pages 242-248

  Sarel, Shalom ^a   Fizames, C ^b   Lavelle, Francois ^b   Avramovici Grisaru, Shelly ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,5 DICHLOROSALICYLIDENE) 2 (2' N METHYLPYRIDINIUM)HYDRAZINE IODIDE; 1 (3,5 DICHLOROSALICYLIDENE) 2 (2' PYRIDYL)HYDRAZINE; 1 (5' CHLOROSALICYCLIDENE) 2 [N (ETHOXYCARBONYLMETHYL)ISONICOTINOYL]HYDRAZINE; 1 (PYRIDOXYLIDENE) 2 (3',5' DICHLORO 2' PYRIDYL)HYDRAZINE; 1 (PYRIDOXYLIDENE) 2 (6' PURINYL)HYDRAZINE; ANTINEOPLASTIC AGENT; HYDROXYUREA; UNCLASSIFIED DRUG; ENZYME INHIBITOR; HYDRAZINE DERIVATIVE; RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG EFFECT; ENZYME INHIBITION; IRON CHELATION; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; SARCOMA; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; ENZYME INHIBITORS; HYDRAZINES; MALE; MASS SPECTROMETRY; MICE; MOLECULAR STRUCTURE; RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0032589746     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980395l     Document Type: Article

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