Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 5983-5988

  Fujii, Hideaki ^a   Ogawa, Ryo ^a   Ohata, Kenji ^a   Nemoto, Toru ^a   Nakajima, Mayumi ^b   Hasebe, Ko ^b   Mochizuki, Hidenori ^b   Nagase, Hiroshi ^a  

^a KITASATO UNIVERSITY   (Japan)

^b TORAY INDUSTRIES INC   (Japan)

Author keywords

Aerobic oxidation; Morphinan; Opioid; Rearrangement

Indexed keywords

16 (CYCLOPROPYLMETHYL) 13BETA HYDROXY 3 METHOXY C NORMORPHINAN 6 SPIRO 2' INDOLIN 3' ONE; 16 (CYCLOPROPYLMETHYL) 3,13BETA DIHYDROXY C NORMORPHINAN 6 SPIRO 2' INDOLIN 3' ONE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; INDOLENINOMORPHINAN; INDOLOMORPHINAN; KAPPA OPIATE RECEPTOR; MORPHINAN DERIVATIVE; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; OPIATE; SPIROINDANYLOXYMORPHONE; SPIROINDOLINONYL C NORMORPHININAN; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; CATALYST; CHEMICAL REACTION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; GUINEA PIG; NONHUMAN; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE;

CATALYSIS; COMPETITIVE BIDDING; MORPHINANS; OXIDATION-REDUCTION; PLATINUM; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU;

EID: 68149122177     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.067     Document Type: Article

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