Inhibition of voltage-gated L-type calcium channels by labedipinedilol-A involves protein kinase C in rat cerebrovascular smooth muscle cells

Vascular Pharmacology

Volumn 51, Issue 2-3, 2009, Pages 65-71

  Wu, Bin Nan ^a   Chen, Mu Long ^a   Dai, Zen Kong ^a,b   Lin, Yi Ling ^a   Yeh, Jwu Lai ^a   Wu, Jiunn Ren ^b   Chen, Ing Jun ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cerebrovascular smooth muscle cells; L type Ca2+ channels; Labedipinedilol A; Patch clamp electrophysiology; Protein kinase C

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CHELERYTHRINE; LABEDIPINEDILOL A; NIFEDIPINE; NORADRENALIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; RHO KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ARTERY; CEREBROVASCULAR SMOOTH MUSCLE CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG SELECTIVITY; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; ENZYME ACTIVITY; FEMALE; HEART MUSCLE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; STEADY STATE; VASCULAR SMOOTH MUSCLE; WHOLE CELL;

ADRENERGIC ALPHA-ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; ANISOLES; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; CEREBRAL ARTERIES; DIHYDROPYRIDINES; ENZYME ACTIVATION; FEMALE; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; SODIUM CHANNEL BLOCKERS; TIME FACTORS;

EID: 68049132869     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vph.2009.03.001     Document Type: Article

References (21)

1. 2+ stores. J. Biol. Chem. 268 (1993) 6945-6952
2. Catterall W.A. Molecular properties of sodium and calcium channels. J. Bioenerg. Biomembranes 28 (1996) 219-230
3. Facemire C.S., and Arendshorst W.J. Calmodulin mediates norepinephrine-induced receptor-operated calcium entry in preglomerular resistance arteries. Am. J. Physiol., Renal Physiol. 289 (2005) F127-F136
4. 2+ currents in intestinal and vascular smooth muscle. Br. J. Pharmacol. 149 (2006) 155-162
5. Hering S., Aczél S., Kraus R.L., Berjukow S., Striessnig J., and Timin E.N. Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: role of inactivation. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 13323-13328
6. Kimura M., Obara K., Sasase T., Ishikawa T., Tanabe Y., and Nakayama K. Specific inhibition of stretch-induced increase in L-type calcium channel currents by herbimycin A in canine basilar arterial myocytes. Br. J. Pharmacol. 130 (2000) 923-931
7. 2+ release and entry during contraction elicited by norepinephrine in rat resistance arteries. Am. J. Physiol. 276 (1999) H300-H308
8. Lee K.S., and Tsien R.W. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature 302 (1983) 790-794
9. Liang J.C., Yeh J.L., Chiang L.C., Yang Y.C., Sheu S.H., Lai W.T., and Chen I.J. Labedipinedilol-A: a vanilloid-based α/β-adrenoceptor blocker with calcium entry blocking and long acting anti-hypertensive properties. Drug Dev. Res. 49 (2000) 94-108
10. Liang J.C., Chen H.R., Chiu C.C., Liou S.F., Chen I.J., and Yeh J.L. Protective effect of labedipinedilol-A, a novel dihydropyridine-type calcium channel blocker, on myocardial apoptosis in ischemia-reperfusion injury. Life Sci. 79 (2006) 1248-1256
11. Liou S.F., Yeh J.L., Liang J.C., Chiu C.C., Lin Y.T., and Chen I.J. Inhibition of mitogen-mediated proliferation of rat vascular smooth muscle cells by labedipinedilol-A through PKC and ERK 1/2 pathway. J. Cardiovasc. Pharmacol. 44 (2004) 539-551
12. Liou S.F., Wu J.R., Lai W.T., Sheu S.H., Chen I.J., and Yeh J.L. The vasorelaxing action of labedipinedilol-A involves endothelial cell-derived NO and eNOS expression caused by calcium influx. J. Cardiovasc. Pharmacol. 45 (2005) 232-240
13. McFadzean I., and Gibson A. The developing relationship between receptor-operated and store-operated calcium channels in smooth muscle. Br. J. Pharmacol. 135 (2002) 1-13
14. 2+ channels. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 11112-11117
15. Slish D.F., Welsh D.G., and Brayden J.E. Diacylglycerol and protein kinase C activate cation channels involved in myogenic tone. Am. J. Physiol, Heart Circ. Physiol. 283 (2002) H2196-H2201
16. 2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Circ. Res. 95 (2004) 406-414
17. 2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855, but not Thr-697. Biochem. J. 389 (2005) 763-774
18. Ca channels in basilar artery myocytes via cyclic nucleotide-dependent protein kinases. Br. J. Pharmacol. 146 (2005) 862-871
19. + channel in cerebral arterial smooth muscle cells. Am. J. Physiol, Heart Circ. Physiol. 292 (2007) H1085-H1094
20. Ca channels via cyclic AMP- and cyclic GMP-dependent protein kinases by eugenosedin-A in rat basilar artery myocytes. Br. J. Pharmacol. 152 (2007) 374-385
21. Yeh J.L., Liang J.C., Liou S.F., Lin Y.T., Sheu S.H., Lai W.T., Shin S.J., and Chen I.J. Ventricular PKC-ε and humoral signaling in DOCA-salt rats treated with labedipinedilol-A. Drug Dev. Res. 59 (2003) 309-315