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Volumn 49, Issue 2, 2000, Pages 94-108

Labedipinedilol-A: A vanilloid-based α/β-adrenoceptor blocker with calcium entry blocking and long-acting antihypertensive properties

Author keywords

adrenoceptor blockade; 1,4 dihydropyridines; Calcium channel blockade; Vanilloid based

Indexed keywords

ANTIHYPERTENSIVE AGENT; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; LABEDIPINEDILOL A; NIFEDIPINE; UNCLASSIFIED DRUG;

EID: 0033911860     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(200002)49:2<94::AID-DDR3>3.0.CO;2-V     Document Type: Article
Times cited : (17)

References (35)
  • 1
    • 0025113524 scopus 로고
    • Pharmacological profiles of YM-16151-1 and optical isomers: A novel calcium entry blocking and selective beta-1 adrenoceptor blocking agent
    • Asano M, Uchida W, Shibasaki K, Terai M, Inagaki O, Takenaka T, Matsumuto Y, Fujikura T. 1990. Pharmacological profiles of YM-16151-1 and optical isomers: a novel calcium entry blocking and selective beta-1 adrenoceptor blocking agent. J Pharmacol Exp Ther 296:204-211.
    • (1990) J Pharmacol Exp Ther , vol.296 , pp. 204-211
    • Asano, M.1    Uchida, W.2    Shibasaki, K.3    Terai, M.4    Inagaki, O.5    Takenaka, T.6    Matsumuto, Y.7    Fujikura, T.8
  • 2
    • 0015429555 scopus 로고
    • The assessment of β-adrenoceptor blocking potency and cardioselectivity in vitro and in vivo
    • Baird JR, Linnell J. 1972. The assessment of β-adrenoceptor blocking potency and cardioselectivity in vitro and in vivo. J Pharm Pharmacol 24:880-885.
    • (1972) J Pharm Pharmacol , vol.24 , pp. 880-885
    • Baird, J.R.1    Linnell, J.2
  • 3
    • 0031437326 scopus 로고    scopus 로고
    • Cardiovascular care with the new T-type calcium channel antagonist: Possible role of attendant sympathetic nervous system inhibition
    • Bühler FR. 1997. Cardiovascular care with the new T-type calcium channel antagonist: possible role of attendant sympathetic nervous system inhibition. J Hypertens 15:S3-7.
    • (1997) J Hypertens , vol.15
    • Bühler, F.R.1
  • 5
    • 0027439990 scopus 로고
    • Xanthonolol: A calcium channel and β-adrenoceptor blocker with vasodilating properties
    • Chen IJ, Lion SJ, Lion SS, Lin CN. 1993. Xanthonolol: a calcium channel and β-adrenoceptor blocker with vasodilating properties. Gen Pharmacol 24:1425-1433.
    • (1993) Gen Pharmacol , vol.24 , pp. 1425-1433
    • Chen, I.J.1    Lion, S.J.2    Lion, S.S.3    Lin, C.N.4
  • 6
    • 0029811699 scopus 로고    scopus 로고
    • Capsinolol: The first β-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart
    • Chen IJ, Yeh JL, Lo YC, Sheu SH, Lin YT, 1996. Capsinolol: the first β-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart. Br J Pharmacol 119:7-14.
    • (1996) Br J Pharmacol , vol.119 , pp. 7-14
    • Chen, I.J.1    Yeh, J.L.2    Lo, Y.C.3    Sheu, S.H.4    Lin, Y.T.5
  • 7
    • 0030810425 scopus 로고    scopus 로고
    • 2-agonist and calcium mobilization inhibition associated vasorelaxant activities
    • 2-agonist and calcium mobilization inhibition associated vasorelaxant activities. Drug Dev Res 40:239-245.
    • (1997) Drug Dev Res , vol.40 , pp. 239-245
    • Chen, S.J.1    Huang, Y.C.2    Wu, B.N.3    Chen, I.J.4
  • 8
    • 0025217532 scopus 로고
    • Coupling mechanisms in airway smooth muscle
    • Coburn RF, Baron CB. 1990. Coupling mechanisms in airway smooth muscle. Am J Rhysiol 258:L119-L133.
    • (1990) Am J Rhysiol , vol.258
    • Coburn, R.F.1    Baron, C.B.2
  • 9
    • 0032127809 scopus 로고    scopus 로고
    • Rat model of hypertension, cardiac hypertrophy and failure
    • Doggrell SA, Brown L. 1998. Rat model of hypertension, cardiac hypertrophy and failure. Cardiovasc Res 39:89-105.
    • (1998) Cardiovasc Res , vol.39 , pp. 89-105
    • Doggrell, S.A.1    Brown, L.2
  • 10
    • 84886637659 scopus 로고
    • Clinical pharmacology of the new beta-adrenergic blocking drugs. Part 4. Adverse effects. Choosing a β-adrenoceptor blocker
    • Frishman W, Silverman R, Strom J, Elkayam U, Sonnenblick E. 1979. Clinical pharmacology of the new beta-adrenergic blocking drugs. Part 4. Adverse effects. Choosing a β-adrenoceptor blocker. Ann Heart J 98:256-262.
    • (1979) Ann Heart J , vol.98 , pp. 256-262
    • Frishman, W.1    Silverman, R.2    Strom, J.3    Elkayam, U.4    Sonnenblick, E.5
  • 13
    • 0021129775 scopus 로고
    • Calcium channels in smooth muscle
    • Karaki H, Weiss GB. 1984. Calcium channels in smooth muscle. Gastroeuterology 87:960-970.
    • (1984) Gastroeuterology , vol.87 , pp. 960-970
    • Karaki, H.1    Weiss, G.B.2
  • 15
    • 0025217933 scopus 로고
    • Factors affecting rabbit mesenteric artery smooth muscle sensitivity to calcium antagonists
    • Meisheri KD, Sage GP, Cipkus-Dubray LA. 1990. Factors affecting rabbit mesenteric artery smooth muscle sensitivity to calcium antagonists. J Pharmacol Exp Ther 252:1167-1174.
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 1167-1174
    • Meisheri, K.D.1    Sage, G.P.2    Cipkus-Dubray, L.A.3
  • 16
    • 0032940764 scopus 로고    scopus 로고
    • Pharmacologic characterization of FR172516: A new combined calcium channel-blocking and β-adrenoceptor-blocking agent
    • Nobuhiro Y, Masahiko N, Kazumi O, Kazuhiro M, Toshio G. 1999. Pharmacologic characterization of FR172516: a new combined calcium channel-blocking and β-adrenoceptor-blocking agent J Cardiovasc Pharmacol 33:587-594.
    • (1999) J Cardiovasc Pharmacol , vol.33 , pp. 587-594
    • Nobuhiro, Y.1    Masahiko, N.2    Kazumi, O.3    Kazuhiro, M.4    Toshio, G.5
  • 18
    • 0026754564 scopus 로고
    • Carvedilol: A novel cardiovascular drug with multiple actions
    • Ruffolo RR Jr, Boyle DA, Broobs DP. 1992. Carvedilol: a novel cardiovascular drug with multiple actions. Cardiovasc Drug Rev 10:127-157.
    • (1992) Cardiovasc Drug Rev , vol.10 , pp. 127-157
    • Ruffolo R.R., Jr.1    Boyle, D.A.2    Broobs, D.P.3
  • 20
    • 0026332888 scopus 로고
    • Studies on nilvadipine. I. Synthesis and structure-activity relationships of 1,4-dihydropyridines containing novel substituents at the 2-position
    • Satoh Y, Ichihashi M, Okumura K. 1991. Studies on nilvadipine. I. Synthesis and structure-activity relationships of 1,4-dihydropyridines containing novel substituents at the 2-position. Chem Pharm Bull 39:3189-3201.
    • (1991) Chem Pharm Bull , vol.39 , pp. 3189-3201
    • Satoh, Y.1    Ichihashi, M.2    Okumura, K.3
  • 21
    • 0021709422 scopus 로고
    • Nifedipine and alpha-adrenoceptors in rat aorta. I. Role of extracellular calcium in alpha-1 and alpha-2 adrenoceptor-mediated contraction
    • Scarborough NL. Carrier GO. 1984. Nifedipine and alpha-adrenoceptors in rat aorta. I. Role of extracellular calcium in alpha-1 and alpha-2 adrenoceptor-mediated contraction. J Pharmacol Exp Ther 231:597-602.
    • (1984) J Pharmacol Exp Ther , vol.231 , pp. 597-602
    • Scarborough, N.L.1    Carrier, G.O.2
  • 22
    • 84969001783 scopus 로고
    • The attraction of protein for small molecules and ions
    • Scatchard G. 1949. The attraction of protein for small molecules and ions. Ann NY Acad Sci 51:660-672.
    • (1949) Ann NY Acad Sci , vol.51 , pp. 660-672
    • Scatchard, G.1
  • 23
    • 0030971130 scopus 로고    scopus 로고
    • Vanidilol: A vanilloid-type vasorelaxant and ocular hypotensive beta-adrenoceptor blocker with partial beta-2 agonist activity
    • Sheu MM, Wu BN, Ho WC;, Hong SJ, Chen SJ, Lin YT, Chen IJ. 1997. Vanidilol: a vanilloid-type vasorelaxant and ocular hypotensive beta-adrenoceptor blocker with partial beta-2 agonist activity. Pharmacology 54:211-224.
    • (1997) Pharmacology , vol.54 , pp. 211-224
    • Sheu, M.M.1    Wu, B.N.2    Ho, W.C.3    Hong, S.J.4    Chen, S.J.5    Lin, Y.T.6    Chen, I.J.7
  • 24
    • 0030810580 scopus 로고    scopus 로고
    • Antianginal effects of YM 430, a novel calcium entry-blocking and β-adrenoceptor-blocking agent in several experimental angina models
    • Shibasaki K, Arai Y, Uchida, W, Okazaki T, Asano M, Takenaka T. 1997a. Antianginal effects of YM 430, a novel calcium entry-blocking and β-adrenoceptor-blocking agent in several experimental angina models. Gen Pharmacol 29:545-550.
    • (1997) Gen Pharmacol , vol.29 , pp. 545-550
    • Shibasaki, K.1    Arai, Y.2    Uchida, W.3    Okazaki, T.4    Asano, M.5    Takenaka, T.6
  • 25
    • 0030893924 scopus 로고    scopus 로고
    • Hypotensive effects of YM430, a 1,4-dihydropyridine derivative, in spontaneously hypertensive rats and renal hypertensive dogs
    • Shibasaki K, Takizawa K, Uchda W, Takenaka T. 1997b. Hypotensive effects of YM430, a 1,4-dihydropyridine derivative, in spontaneously hypertensive rats and renal hypertensive dogs. Jpn J Pharmacol 73:113-124.
    • (1997) Jpn J Pharmacol , vol.73 , pp. 113-124
    • Shibasaki, K.1    Takizawa, K.2    Uchda, W.3    Takenaka, T.4
  • 26
    • 0024459688 scopus 로고
    • Cell calcium and its regulation in smooth muscle
    • Somlyo AP, Himpens B. 1989. Cell calcium and its regulation in smooth muscle. FASEB J 3:2266-2267.
    • (1989) FASEB J , vol.3 , pp. 2266-2267
    • Somlyo, A.P.1    Himpens, B.2
  • 27
    • 0029019005 scopus 로고
    • The dose dependency of the alpha-and beta-adrenoceptor antagonist activity of carvedilol on man
    • Tham TC, Guy S, McDermott BJ, Shanks RG, Riddell JG. 1995. The dose dependency of the alpha-and beta-adrenoceptor antagonist activity of carvedilol on man. Br J Clin Pharmaco 40:19-23.
    • (1995) Br J Clin Pharmaco , vol.40 , pp. 19-23
    • Tham, T.C.1    Guy, S.2    McDermott, B.J.3    Shanks, R.G.4    Riddell, J.G.5
  • 28
    • 0027164809 scopus 로고
    • Cardiovascular effects of YM-16151-4: A novel calcium entry blocking and selective beta 1-adrenoceptor blocking agent in rats and dogs
    • Uchida W, Shibasaki K, Matsuda Y, Asano M, Takenaka T. 1993. Cardiovascular effects of YM-16151-4: a novel calcium entry blocking and selective beta 1-adrenoceptor blocking agent in rats and dogs. J Cardiovasc Pharm 22:247-252.
    • (1993) J Cardiovasc Pharm , vol.22 , pp. 247-252
    • Uchida, W.1    Shibasaki, K.2    Matsuda, Y.3    Asano, M.4    Takenaka, T.5
  • 30
    • 0028228055 scopus 로고
    • A new β-adrenoceptor blocking agent derived from dehydrozingerone
    • Wu BN, Yang CR, Yang JM, Chen IJ. 1994b. A new β-adrenoceptor blocking agent derived from dehydrozingerone. Gen Pharmacol 25:651-659.
    • (1994) Gen Pharmacol , vol.25 , pp. 651-659
    • Wu, B.N.1    Yang, C.R.2    Yang, J.M.3    Chen, I.J.4
  • 32
    • 0030036388 scopus 로고    scopus 로고
    • Zingeronolol: A newly developed β-adrenergic blocking agent derived from zingerone, a pungent principle of ginger
    • Wu BN, Ho WC, Chiang LC, Chen IJ. 1996. Zingeronolol: a newly developed β-adrenergic blocking agent derived from zingerone, a pungent principle of ginger. Asia Pac J Pharmacol 11:5-12.
    • (1996) Asia Pac J Pharmacol , vol.11 , pp. 5-12
    • Wu, B.N.1    Ho, W.C.2    Chiang, L.C.3    Chen, I.J.4
  • 34
    • 0027537037 scopus 로고
    • Cardiovascular interactions of nonivamide, glyceryl nonivamide, capsaicin analogues, and substance P antagonist in rats
    • Yen JL, Lo YC, Wang Y, Chen IJ. 1993. Cardiovascular interactions of nonivamide, glyceryl nonivamide, capsaicin analogues, and substance P antagonist in rats. Brain Res Bull 30:641-648.
    • (1993) Brain Res Bull , vol.30 , pp. 641-648
    • Yen, J.L.1    Lo, Y.C.2    Wang, Y.3    Chen, I.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.