Comparative studies of AJG049, a novel Ca 2+ channel antagonist, on voltage-dependent L-type Ca 2+ currents in intestinal and vascular smooth muscle

British Journal of Pharmacology

Volumn 149, Issue 2, 2006, Pages 155-162

  Hashimoto, M ^a   Teramoto, N ^b   Zhu, H L ^b   Takahashi, K ^a   Ito, Y ^b  

^a AJINOMOTO CO INC   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

AJG049; Ca 2+ channel antagonists; Intestinal smooth muscle; Irritable bowel syndrome; L type Ca 2+ channels; Tissue selectivity

Indexed keywords

5,11 DIHYDRO 5 [1 (4 METHOXYPHENETHYL) 2 PYRROLIDINYLMETHYL]DIBENZO[B,E][1,4]OXAZEPINE; AJG 049; BARIUM ION; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; DIBENZOXAZEPINE DERIVATIVE; DILTIAZEM; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL TISSUE; ARTERY MUSCLE; ARTICLE; BINDING AFFINITY; CALCIUM CURRENT; CHANNEL GATING; COLON; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; DRUG POTENCY; GUINEA PIG; ILEUM; INTESTINE MOTILITY; INTESTINE MUSCLE; MALE; MESENTERIC ARTERY; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; VASCULAR SMOOTH MUSCLE;

ANIMALS; BLOOD VESSELS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CEREBRAL CORTEX; GUINEA PIGS; INTESTINES; MALE; MUSCLE, SMOOTH; OXAZEPINES; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33748513269     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706861     Document Type: Article

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