Regulator of calcineurin 1 modulates cancer cell migration in vitro

Clinical and Experimental Metastasis

Volumn 26, Issue 6, 2009, Pages 517-526

  Espinosa, Allan V ^a   Shinohara, Motoo ^a   Porchia, Leonardo M ^a   Chung, Yun Jae ^a,b   McCarty, Samantha ^a   Saji, Motoyasu ^a   Ringel, Matthew D ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b Chung Ang University College of Medicine   (South Korea)

Author keywords

Adhesion; Calcineurin; GPR54; KiSS1; Metastases; Metastin; Motility; Thyroid Cancer

Indexed keywords

CALCINEURIN; CALCINEURIN INHIBITOR; COLLAGEN TYPE 4; DOXYCYCLINE; DRUG VEHICLE; G PROTEIN COUPLED RECEPTOR 54; METASTIN; PROTEASOME INHIBITOR; REGULATOR OF CALCINEURIN 1 PROTEIN; REGULATOR PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INVASION; CELL ADHESION; CELL MOTILITY; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPH NODE METASTASIS; METASTASIS INHIBITION; MIGRATION INHIBITION; RCAN1 GENE; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CALCINEURIN; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOXYCYCLINE; HT29 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUSCLE PROTEINS; NEOPLASMS;

EID: 68049131431     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-009-9251-1     Document Type: Article

References (34)

1. AC Chiang J Massague 2008 Molecular basis of metastasis N Engl J Med 359 26 2814 2823 10.1056/NEJMra0805239
2. AF Chambers AC Groom IC MacDonald 2002 Dissemination and growth of cancer cells in metastatic sites Nat Rev Cancer 2 8 563 572 10.1038/nrc865 (Pubitemid 37328923)
3. S Ramaswamy KN Ross ES Lander 2003 A molecular signature of metastasis in primary solid tumors Nat Genet 33 1 49 54 10.1038/ng1060 (Pubitemid 36068681)
4. K Podsypanina YC Du M Jechlinger 2008 Seeding and propagation of untransformed mouse mammary cells in the lung Science 321 5897 1841 1844 10.1126/science.1161621
5. LA Shevde DR Welch 2003 Metastasis suppressor pathways-an evolving paradigm Cancer Lett 198 1 1 20 10.1016/S0304-3835(03)00304-5 (Pubitemid 37289098)
6. T Ohtake Y Shintani S Honda 2001 Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor Nature 411 6787 613 617 10.1038/35079135 (Pubitemid 32531412)
7. M Kotani M Detheux A Vandenbogaerde 2001 The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 J Biol Chem 276 37 34631 34636 10.1074/jbc.M104847200
8. AI Muir L Chamberlain NA Elshourbagy 2001 AXOR12: a novel human G protein-coupled receptor, activated by the peptide KiSS-1 J Biol Chem 276 31 28969 28975 10.1074/jbc.M102743200
9. JH Lee ME Miele DJ Hicks 1996 KiSS-1, a novel human malignant melanoma metastasis-suppressor gene J Natl Cancer Inst 88 23 1731 1737 10.1093/jnci/88.23.1731
10. MD Ringel E Hardy VJ Bernet 2002 Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells J Clin Endocrinol Metab 87 5 2399 2402 10.1210/jc.87.5.2399 (Pubitemid 34521537)
11. M Ikeguchi K Yamaguchi N Kaibara 2004 Clinical significance of the loss of KiSS-1 and orphan G-Protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma Clin Cancer Res 10 4 1379 1383 10.1158/1078-0432.CCR-1519-02 (Pubitemid 38365232)
12. DK Dhar H Naora H Kubota 2004 Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma Int J Cancer 111 6 868 872 10.1002/ijc.20357 (Pubitemid 39096235)
13. A Hori S Honda M Asada 2001 Metastin suppresses the motility and growth of CHO cells transfected with its receptor Biochem Biophys Res Commun 286 5 958 963 10.1006/bbrc.2001.5470 (Pubitemid 32924865)
14. F Shirasaki M Takata N Hatta 2001 Loss of expression of the metastasis suppressor gene KiSS1 during melanoma progression and its association with LOH of chromosome 6q16.3-q23 Cancer Res 61 20 7422 7425
15. Y Jiang M Berk LS Singh 2005 KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein Kinase C Alpha Clin Exp Metastasis 22 5 369 376 10.1007/s10585-005-8186-4 (Pubitemid 41609296)
16. KT Nash PA Phadke J-M Navenot 2007 Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy J Natl Cancer Inst 99 4 309 321 10.1093/jnci/djk053 (Pubitemid 47078727)
17. N Stathatos I Bourdeau AV Espinosa 2005 KiSS-1/G protein-coupled receptor 54 metastasis suppressor pathway increases myocyte-enriched calcineurin interacting protein 1 expression and chronically inhibits calcineurin activity J Clin Endocrinol Metab 90 9 5432 5440 10.1210/jc.2005-0963 (Pubitemid 41262312)
18. JJ Fuentes MA Pritchard X Estivill 1997 Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene Genomics 44 3 358 361 10.1006/geno.1997.4866 (Pubitemid 27419014)
19. B Rothermel RB Vega J Yang 2000 A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling J Biol Chem 275 12 8719 8725 10.1074/jbc.275.12.8719 (Pubitemid 30180224)
20. RB Vega BA Rothermel CJ Weinheimer 2003 Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy Proc Natl Acad Sci USA 100 2 669 674 10.1073/pnas.0237225100 (Pubitemid 36126110)
21. E van Rooij PA Doevendans HJ Crijns 2004 MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction Circ Res 94 3 e18 e26 10.1161/01.RES.0000118597.54416.00
22. RB Vega J Yang BA Rothermel 2002 Multiple domains of MCIP1 contribute to inhibition of calcineurin activity J Biol Chem 277 33 30401 30407 10.1074/jbc.M200123200
23. S Abbasi J-D Lee B Su 2006 Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1 J Biol Chem 281 12 7717 7726 10.1074/jbc.M510775200 (Pubitemid 43847385)
24. SR Seo KC Chung 2008 CREB activates proteasomal degradation of DSCR1/RCAN1 FEBS Lett 582 13 1889 1893 10.1016/j.febslet.2008.04.059
25. CR Bush JM Havens BM Necela 2007 Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor gamma and calcium signaling in human colorectal cancer cells J Biol Chem 282 32 23387 23401 10.1074/jbc.M702708200 (Pubitemid 47311964)
26. M Iizuka M Abe K Shiiba 2004 Down syndrome candidate region 1, a downstream target of VEGF, participates in endothelial cell migration and angiogenesis J Vasc Res 41 4 334 344 10.1159/000079832 (Pubitemid 39370276)
27. T Minami K Horiuchi M Miura 2004 Vascular endothelial growth factor- and thrombin-induced termination factor, down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis J Biol Chem 279 48 50537 50554 10.1074/jbc.M406454200 (Pubitemid 39577872)
28. RE Schweppe JP Klopper C Korch 2008 Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification J Clin Endocrinol Metab 83 11 4331 4341 10.1210/jc.2008-1102 (Pubitemid 352789529)
29. MD Ringel 2008 "Thyroid cancer" cell line misidentification: a time for proactive change J Clin Endocrinol Metab 93 11 4226 4227 10.1210/jc.2008-2008 (Pubitemid 352789514)
30. V Vasko M Saji E Hardy 2004 Akt activation and localization correlate with tumor invasion and oncogene expression in thyroid cancer J Med Genet 41 3 161 170 10.1136/jmg.2003.015339
31. S Hoffmann K Maschuw I Hassan 2005 Differential pattern of integrin receptor expression in differentiated and anaplastic thyroid cancer cell lines Thyroid 15 9 1011 1020 10.1089/thy.2005.15.1011 (Pubitemid 41475711)
32. Mulero MC, Aubareda A, Orzaez M, et al. (2009) Inhibiting the calcineurin-NFAT signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity. J biol chem [Epub ahead of print]
33. CW Rinker-Schaeffer JP O'Keefe DR Welch 2006 Metastasis suppressor proteins: discovery, molecular mechanisms, and clinical application Clinical Cancer Research 12 13 3882 3889 10.1158/1078-0432.CCR-06-1014 (Pubitemid 44078070)
34. S Ryeom K-H Baek MJ Rioth 2008 Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth Cancer Cell 13 5 420 431 10.1016/j.ccr.2008.02.018 (Pubitemid 351609439)