Continuous production of solid lipid nanoparticles by liquid flow-focusing and gas displacing method in microchannels

Chemical Engineering Science

Volumn 64, Issue 19, 2009, Pages 4115-4122

  Yun, Junxian ^a   Zhang, Songhong ^a,b   Shen, Shaochuan ^a   Chen, Zhuo ^a   Yao, Kejian ^a   Chen, Jizhong ^b  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Hydrodynamics; Nanostructure; Particle formation; Slug flow microreactor; Solid lipid nanoparticles; Transport processes

Indexed keywords

AQUEOUS PHASE; AQUEOUS SOLUTIONS; AQUEOUS SURFACTANT SOLUTIONS; CONTINUOUS PRODUCTION; DIAMETER DISTRIBUTIONS; FLOW BEHAVIORS; FLOW STREAMS; GAS BUBBLE; GAS SLUGS; GAS-LIQUID SLUG FLOW; LIPID CONCENTRATION; LIQUID FLOW; LIQUID SLUG; LIQUID SUSPENSION; LIQUID VELOCITIES; MEAN SIZE; MICROSCOPE SYSTEMS; PARTICLE FORMATION; PARTICLE MORPHOLOGIES; POLYDISPERSITY INDICES; PREPARING PROCESS; PRODUCTION METHODS; SLUG FLOW; SLUG FLOW MICROREACTOR; SMALL SIZE; SOLID LIPID NANOPARTICLES; T JUNCTIONS; TAYLOR BUBBLES; TRANSFER MECHANISMS; TRANSPORT PROCESSES; WATER-MISCIBLE ORGANIC SOLVENTS;

BUBBLES (IN FLUIDS); DROP FORMATION; EFFLUENT TREATMENT; FLUID DYNAMICS; FOCUSING; HOMOGENIZATION METHOD; HYDRODYNAMICS; INERT GASES; LIGHT TRANSMISSION; LIQUIDS; MICROCHANNELS; MICROEMULSIONS; NANOPARTICLES; ORE TREATMENT; ORGANIC SOLVENTS; PARTICLE SIZE; PARTICLE SIZE ANALYSIS; POLYDISPERSITY; SIZE DISTRIBUTION; SUPERCRITICAL FLUIDS; SURFACE ACTIVE AGENTS; TRANSMISSION ELECTRON MICROSCOPY;

SUSPENSIONS (FLUIDS);

EID: 68049129537     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2009.06.047     Document Type: Article

References (34)

1. Almeida A.J., and Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Advanced Drug Delivery Reviews 59 (2007) 478-490
2. Alexandridis P., Athanassiou V., Fukuda S., and Hatton T.A. Surface activity of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) copolymers. Langmuir 10 (1994) 2604-2612
3. Cabassud C., Laborie S., Durand-Bourlier L., and Lainé J.M. Air sparging in ultrafiltration hollow fibers: relationship between flux enhancement, cake characteristics and hydrodynamic parameters. Journal of Membrane Science 181 (2001) 57-69
4. Charcosset C., El-Harati A.A., and Fessi H. Preparation of solid lipid nanoparticles using a membrane contactor. Journal of Controlled Release 108 (2005) 112-120
5. Charcosset C., El-Harati A.A., and Fessi H. A membrane contactor for the preparation of solid lipid nanoparticles. Desalination 200 (2006) 570-571
6. Chattopadhyay P., Shekunov B.Y., Yim D., Cipolla D., Boyd B., and Farr S. Production of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx system. Advanced Drug Delivery Reviews 59 (2007) 444-453
7. Cui Z.F., Chang S., and Fane A.G. The use of gas bubbling to enhance membrane processes. Journal of Membrane Science 221 (2003) 1-35
8. Elversson J., and Millqvist-Fureby A. In situ coating-an approach for particle modification and encapsulation of proteins during spray-drying. International Journal of Pharmaceutics 323 (2006) 52-63
9. Garstecki P., Fuerstman M.J., Stonec H.A., and Whitesides G.M. Formation of droplets and bubbles in a microfluidic T-junction-scaling and mechanism of break-up. Lab Chip 6 (2006) 437-446
10. Gasco M.C. Lipid nanoparticles: perspectives and challenges. Advanced Drug Delivery Reviews 59 (2007) 377-378
11. Ghosh R., and Cui Z.F. Mass transfer in gas-sparged ultrafiltration: upward slug flow in tubular membranes. Journal of Membrane Science 162 (1999) 91-102
12. Jahn A., Vreeland W.N., Gaitan M., and Locascio L.E. Controlled vesicle self-assembly in microfluidic channels with hydrodynamic focusing. Journal of the American Chemical Society 126 (2004) 2674-2675
13. Kockmann N., Kastner J., and Woias P. Reactive particle precipitation in liquid microchannel flow. Chemical Engineering Journal 135S (2008) S110-S116
14. 2 fine particles and increase of particle size using a two-stage slug flow tubular reactor. Chemical Engineering Research and Design 77 (1999) 335-341
15. Mehnert W., and Mäder K. Solid lipid nanoparticles production, characterization and applications. Advanced Drug Delivery Reviews 47 (2001) 165-196
16. Müller R.H., Mehnert W., Lucks J.S., Schwarz C., Muhlen A.Z., Weyhers H., Frieras C., and Ruhl D. Solid lipid nanoparticles (SLN)-an alternative colloidal carrier system for controlled drug delivery. European Journal of Pharmaceutics and Biopharmaceutics 41 (1995) 62-69
17. Müller R.H., Mäder K., and Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics 50 (2000) 161-177
18. Pornsunthorntawee O., Wongpanit P., Chavadej S., Abe M., and Rujiravanit R. Structural and physicochemical characterization of crude biosurfactant produced by Pseudomonas aeruginosa SP4 isolated from petroleum-contaminated soil. Bioresource Technology 99 (2008) 1589-1595
19. Salazar-Alvarez G., Muhammed M., and Zagorodni A.A. Novel flow injection synthesis of iron oxide nanoparticles with narrow size distribution. Chemical Engineering Science 61 (2006) 4625-4633
20. Schubert M.A., and Müller-Goymann C.C. Solvent injection as a new approach for manufacturing lipid nanoparticles-evaluation of the method and process parameters. European Journal of Pharmaceutics and Biopharmaceutics 55 (2003) 125-131
21. Sugiura S., Nakajima M., Tong J., Nabetani H., and Seki M. Preparation of monodispersed solid lipid microspheres using a microchannel emulsification technique. Journal of Colloid and Interface Science 227 (2000) 95-103
22. Thulasidas T.C., Abraham M.A., and Cerro R.L. Flow patterns in liquid slugs during bubble-train flow inside capillaries. Chemical Engineering Science 52 (1997) 2947-2962
23. Takagi M., Maki T., Miyahara M., and Mae K. Production of titania nanoparticles by using a new microreactor assembled with same axle dual pipe. Chemical Engineering Journal 101 (2004) 269-276
24. van Steijn V., Kreutzer M.T., and Kleijn C.R. μ-PIV study of the formation of segmented flow in microfluidic T-junctions. Chemical Engineering Science 62 (2007) 7505-7514
25. van der Graaf S., Steegmans M.L.J., van der Sman R.G.M., Schroën C.G.P.H., and Boom R.M. Droplet formation in a T-shaped microchannel junction: a model system for membrane emulsification. Colloids and Surfaces A: Physicochemical and Engineering Aspects 266 (2005) 106-116
26. Vladisavljević G.T., Kobayashi I., and Nakajima M. Generation of highly uniform droplets using asymmetric microchannels fabricated on a single crystal silicon plate: effect of emulsifier and oil types. Powder Technology 183 (2008) 37-45
27. Wagner J., Kirner T., Mayer G., Albert J., and Köhler J.M. Generation of metal nanoparticles in a microchannel reactor. Chemical Engineering Journal 101 (2004) 251-260
28. Warnier M.J.F., Rebrov E.V., de Croon M.H.J.M., Hessel V., and Schouten J.C. Gas hold-up and liquid film thickness in Taylor flow in rectangular microchannels. Chemical Engineering Journal 135 (2008) S153-S158
29. Wissing S.A., Kayser O., and Müller R.H. Solid lipid nanoparticles for parenteral drug delivery. Advanced Drug Delivery Reviews 56 (2004) 1257-1272
30. Ying Y., Chen G.W., Zhao Y.C., Li S.L., and Yuan Q. A high throughput methodology for continuous preparation of monodispersed nanocrystals in microfluidic reactors. Chemical Engineering Journal 135 (2008) 209-215
31. Yun J.X., and Shen Z.Q. Modeling of solid layer growth from melt for Taylor bubbles rising in a vertical crystallization tube. Chemical Engineering Science 58 (2003) 5257-5268
32. Yun J.X., and Shen Z.Q. Hydrodynamics of an external-loop gas-lift system with restrictions located in the downcomer. Chemical Engineering Science 58 (2003) 377-385
33. Zhang S.H., Yun J.X., Shen S.C., Chen Z., Yao K.J., Chen J.Z., and Chen B.B. Preparation of solid lipid nanoparticles in co-flowing microchannel. Chemical Engineering Journal 144 (2008) 324-328
34. Zhang S.H., Yun J.X., Shen S.C., Chen Z., Yao K.J., Chen J.Z., and Chen B.B. Formation of solid lipid nanoparticles in a microchannel system with a cross-shaped junction. Chemical Engineering Science 63 (2008) 5600-5605