Conjugated linoleic acid (CLA): Effect modulation of body composition and lipid profile

Nutricion Hospitalaria

Volumn 24, Issue 4, 2009, Pages 422-428

  Baddini Feitoza, Adriana ^a,b   Fernandes Pereira, A ^a   Ferreira Da Costa, N ^a   Goncalves Ribeiro B ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b NONE   (Brazil)

Author keywords

Body composition; Conjugated linoleic acid; Fat percentage; Lipid metabolism

Indexed keywords

APOLIPOPROTEIN B; CONJUGATED LINOLEIC ACID; GLUCOSE TRANSPORTER 4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LINOLEIC ACID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POLYUNSATURATED FATTY ACID;

BODY COMPOSITION; BODY FAT; BODY MASS; CHEMICAL BOND; CONJUGATION; DIET SUPPLEMENTATION; FATTY ACID METABOLISM; HUMAN; INSULIN RESISTANCE; ISOMER; LIPID ANALYSIS; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; NONHUMAN; REVIEW;

EID: 68049126530     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: None     Document Type: Review

References (69)

1. Miner JL, Cederberg CA, Nielsen MK, Chen X, Baile CA. Conjugated linoleic acid (CLA), body fat, and apoptosis. Obes Res 2001; 9: 129-134 (Pubitemid 33603839)
2. Sisk MB, Hausman DB, Martin RJ, Azain MJ. Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. J Nutr 2001; 131: 1668-1674. (Pubitemid 32520430)
3. Azain MJ, Hausman DB, Sisk MB, Flatt WP, Jewell DE. Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J Nutr 2000; 130 (6): 1548-1554 (Pubitemid 30340701)
4. Gavino VC, Gavino G, Leblanc MJ, Tuchweber B. An isomeric mixture of conjugated linoleic acids but not pure cis-9, trans- 11-octadecadienoic acid affects body weight gain and plasma lipids in hamsters. J Nutr 2000; 130: 27-29. (Pubitemid 30032824)
5. Muller HL, Kirchgessner M, Roth FX, Stangl GI. Effect of conjugated linoleic acid on energy metabolism in growing-finishing pigs. J Anim Physiol a Anim Nutr 2000; 83: 85-94.
6. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K y cols. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 2000; 49 (9): 1534-1542 (Pubitemid 30677247)
7. West DB, Blohm FY, Truett AA, DeLany JP. Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression. J Nutr 2000; 130 (10): 2471-2477 (Pubitemid 30737861)
8. Wilson TA, Nicolosi RJ, Chrysam M, Kritchevsky D. Conjugated Linoleic Acid Reduces Early Aortic Atherosclerosis Greater Than Linoleic Acid in Hypercholesterolemic Hamsters. Nutr Res 2000; 20: 1795-1805 (Pubitemid 32040956)
9. De Deckere EAM, Van Amelsvoort JM, McNeill GP, Jones P. Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. Br J Nutr 1999; 82 (4): 309-317 (Pubitemid 29481517)
10. Muller HL, Stangl GI, Kirchgessner M. Energy balance of conjugated linoleic acid treated pigs. J Anim Physiol a Anim Nutr 1999; 81: 150-156. (Pubitemid 129492287)
11. Park Y, Albright KJ, Storkson JM, Liu W, Cook ME, Pariza MW. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 1999; 34 (3): 243-248 (Pubitemid 29169627)
12. West DB, Delany JP, Camet PM, Blohm F, Truett AA, Scimeca J. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol 1998; 275 (3): R667- 672. (Pubitemid 28439808)
13. Nicolosi RJ, Rogers EJ, Kritchevsky D, Scimeca JA, Huth PJ. Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery 1997; 22: 266-277. (Pubitemid 27264009)
14. Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice. Lipids 1997; 32 (8): 853-858 (Pubitemid 27360392)
15. Lee KN, Kritchevsky D, Pariza MW. Conjugated Linoleic Acid and Atherosclerosis in Rabbits. Atherosclerosis 1994; 108: 19-25.
16. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H & Gudmundsen O. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. American Journal of Clinical Nutrition 2004; 79: 1118-1125. (Pubitemid 41095966)
17. Noone EJ, Roche HM, Nugent AP, Gibney MJ. The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. British Journal of Nutrition 2002; 88: 243-251. (Pubitemid 34987661)
18. Risérus U, Berglund L, Vessby B. Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int J Obes 2001; 25 (8): 1129-1135 (Pubitemid 32721534)
19. Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans-metabolic effects. Lipids 2001; 36 (8): 773-781 (Pubitemid 32924104)
20. Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat in healthy exercising humans. Journal of International Medical Research 2001; 29: 392-396 (Pubitemid 33061658)
21. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000; 130 (12): 2943-2948 (Pubitemid 32005322)
22. Atkinson RL. Conjugated linoleic acid for altering body composition and treating obesity. In: Yurawecz MP, Mossoba MM, Kramer JKG, Pariza MW, Nelson GJ (eds.). Advances in Conjugated Linoleic Acid Research. Champaign, IL: AOCS Press; 1999; 328-353.
23. Smedman AEM, Gustafsson I-B, Berglund LGT, Vessby BOH. Pentadecanoic acid as a marker for intake of milk fat: relation between intake of milk fat and metabolic risk factors. Am J Clin Nutr 1999; 69: 22-29 (Pubitemid 29031247)
24. Clement L, Poirier H, Niot I et al. Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res 2002; 43: 1400-1409.
25. Martin JC, Valeille K. Conjugated linoleic acids: all the same or to everyone its own function? Reprod Nutr Dev 2002; 42: 525-536 (Pubitemid 36267559)
26. Pariza MW, Park Y, Cook ME. The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 2001; 40 (4): 283-298 (Pubitemid 32547235)
27. Park Y, Storkson JM, Albright KJ, Liu W, Pariza MW. Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 1999; 34 (3): 235-241 (Pubitemid 29169626)
28. Griinari JM, Corl BA, Lacy SH, Chouinard PY, Nurmela KVV, Bauman DE. Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by D9-desaturase. J Nutr 2000; 130: 2285-2291 (Pubitemid 30682749)
29. Belury MA. Dietary Conjugated Linoleic Acid in Health: Physiological Effects and Mechanisms of Action. Annu Rev Nutr 2002; 22: 505-531 (Pubitemid 35221471)
30. McGuire MA, McGuire MK, McGuire MS, Griinari JM. Bovine Acid: The Natural CLA. In: Cornell Nutrition Conference Feed Manufacturers 1997; 59: 217-226
31. Medeiros SR. Ácido linoleico conjugado: teores nos alimentos e seu uso no aumento da produção de leite, com maior teor de proteína e perfil de ácidos graxos modificado [PhD dissertation]. São Paulo: Escola Superior de Agricultura Luiz de Queiroz. 2002.
32. Kelly GS. Conjugated linoleic acid: A review. Altern Med Rev 2001; 6 (4): 367-382
33. Steinhart C. Conjugated linoleic acid the good news about animal fat. Journal of Chemical Education 1996; 73 (12): 302-303.
34. Shantha NC, Crum AD, Decker EA. Evaluation of conjugated linoleic acid concentrations in cooked beef. J Agric Food Chem 1994; 42: 1757-1760.
35. Shantha NC, Decker EA. Conjugated linoleic acid concentrations in processed cheese containing hydrogen donors, iron and dairy-based additives. Food Chem 1993; 47: 257-261. (Pubitemid 23162212)
36. Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J Food Compos Anal 1992; 5: 185-197
37. Ritzenthaler KL, McGuire MK, Falen R, Schultz TD, Dasgupta N, McGuire MA. Estimation of Conjugated Linoleic Acid Intake by Written Dietary Assessment Methodologies Underestimates Actual Intake Evaluated by Food Duplicate Methodology. J Nutr 2001; 131: 1548-1554 (Pubitemid 32422981)
38. Britton M, Fong C, Wickens D, Yudkin J. Diet as a source of phospholipid esterified 9,11-octadecadienoic acid in humans. Clin Sci 1992; 83: 97-101.
39. Huang YC, Luedecke LO, Schultz TD. Effect of cheddar cheese consumption on plasma conjugated linoleic acid concentrations in men. Nutr Res 1994; 14: 373-386. (Pubitemid 24068806)
40. Zambell KL, Keim NL, Van Loan MD et al. Conjugated linoleic acid supplementation in humans: Effects on body composition and energy expenditure. Lipids 2000; 35 (7): 777-782 (Pubitemid 30624543)
41. Risérus U, Vessby B, Arnlov J, Basu S. Effects of cis-9, trans- 11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 2004; 80: 279-283. (Pubitemid 41079999)
42. Malpuech-Brugere C, Verboeket-van de Venne WP, Mensink RP et al. Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obesity Research 2004; 12: 591-598. (Pubitemid 41132501)
43. Tricon S, Burdge GC, Russell JJ et al. Opposing effects of cis- 9,trans-11 and trans-10, cis-12 CLA on blood lipids in healthy humans. American Journal of Clinical Nutrition 2004; 80: 614-620. (Pubitemid 41115525)
44. Kreider RB, Ferreira MP, Greenwood M, Wilson M, Almada AL. Effects of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. Journal of Strength and Conditioning Research 2002; 16: 325-334.
45. Silveira M-B, Carraro R, Monereo S and Tébar J. Conjugated linoleic acid (CLA) and obesity. Public Health Nutrition 2007; 10 (10A): 1181-1186. (Pubitemid 350085207)
46. House RL, Cassady JP, Eisen EJ, McIntoshand MK, Odle J. Conjugated linoleic acid evokes de-lipidation through the regulation of genes controlling lipid metabolism in adipose and liver tissue. Obesity Reviews 2005; 6: 247-258. (Pubitemid 41032800)
47. Choi Y, Kim Y-C, Han YB, Park Y, Pariza MW, Ntambi JM. The trans-10, cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J Nutr 2000; 130: 1920-1924. (Pubitemid 30497521)
48. Lee KN, Pariza MW, Ntambi JM. Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase MRNA expression. Biochem Biophys Res Commun 1998; 248: 817-821. (Pubitemid 28404506)
49. Houseknecht KL, Van den Heuvel JP, Moya-Camarena SY et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochemical and Biophysical Research Communications 1998; 247: 911-1911
50. Wang Y, Jones PJH. Dietary conjugated linoleic acid and body composition. Am J Clin Nutr 2004; 79: 1153S-1158S.
51. Kamphuis MM, Lejeune MP, Saris WH, Westerterp-Plantenga MS. The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. Int J Obes 2003; 27 (7): 840-847 (Pubitemid 36819543)
52. Park YM, Pariza W. Mechanisms of body composition by conjugatd linoleic acid (CLA). Food International Research 2007; 40: 311-323. (Pubitemid 46124004)
53. Kritchevsky D. Antimutagenic and some other effects of conjugated linoleic acid. Br J Nutr 2000; 83: 459-465 (Pubitemid 30319061)
54. Benito P, Nelson GJ, Kelley DS, Bartolini G, Schmidt PC, Simon V. The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans. Lipids 2001; 36: 229-236. (Pubitemid 32290917)
55. Risérus U, Brismar K, Arner P, Vessby B. Treatment with dietary trans-10, cis-12 conjugated linoleic acid causes isomerspecific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 2002; 25: 1516-1521. (Pubitemid 41071104)
56. Yotsumoto H, Hara E, Naka S, Adlof RO, Emken EA, Yanagita T. 10 trans, 12 cis-linoleic acid reduces apolipoprotein B secretion in HepG2 cells. Food Res Int 1999; 31: 403-409.
57. Lin Y, Schuurbiers E, Van der Veen S, De Deckere EA. Conjugated linoleic acid isomers have differential effects on triglyceride secretion in Hep G2 cells. Biochim Biophys Acta 2001; 1533: 38-46. (Pubitemid 32763264)
58. Terpstra AH. Effect of conjugated linoleic acid on body composition and plasma lipid in humans: an overview of the literature. Am J Clin Nutr 2004; 79: 352-361 (Pubitemid 41115576)
59. Moloney F, Toomey S, Noone E et al. Antidiabetic Effects of cis-9, trans-11 -Conjugated Linoleic Acid May Be Mediated via Anti-Inflammatory: Effects in White Adipose Tissue. Diabetes 2007; 56: 574-582. (Pubitemid 46348448)
60. Roger S McL, LeBlanc AM, Langille MA, Mitchell PL, Currie DL. Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolism. Am J Clin Nutr 2004; 79: 1169-1174
61. Pariza MW, Park Y, Cook ME. Mechanisms of action of conjugated linoleic acid: Evidence and Speculation. Proceedings of Society for Experimental Biology and Medicine 2000; 223: 8-13. (Pubitemid 30182652)
62. Santomauro AT, Boden G, Silva ME et al. Overnight Lowering of Free Fatty Acids with Acipimox Improves Insulin Resistance and Glucose Tolerance in Obese Diabetic and Nondiabetic Subjects. Diabetes 1999; 48: 1836-1841. (Pubitemid 29415205)
63. Brown JM, McIntosh MK. Conjugated Linoleic Acid in Humans: regulation of adiposity and insulin sensitivity. J Nutr 2003; 133: 3041-3046. (Pubitemid 37222212)
64. Mougios V, Matsakas A, Petridou A et al. Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. J Nutr Biochem 2001; 12: 585-594 (Pubitemid 32930054)
65. Larsen TM, Toubro S, Astrup A. Efficacy and safety of dietary supplements containing CLA for the treatment of obesity: evidence from animal and human studies. J Lipid Res 2003; 44: 2234-2241. (Pubitemid 38082481)
66. Luyckx FH, Desaive C, Thiry A et al. Liver abnormalities in severely obese subjects: effect of drastic weight loss after gastroplasty. Int J Obes Relat Metab Disord 1998; 22: 222-226. (Pubitemid 28112021)
67. Medina EA, Horn WF, Keim NL et al. Conjugated linoleic acid supplementation in humans: Effects on circulating leptin concentrations and appetite. Lipids 2000; 35: 783-788. (Pubitemid 30624544)
68. Baile CA, Della-Fera MA, Martin RJ. Regulation of metabolism and body fat mass by leptin. Annu Rev Nutr 2000; 20: 105-127 (Pubitemid 30707976)
69. Whigham LD, O'Shea M, Mohede IC, Walaski HP, Atkinson RL. Safety profile of conjugated linoleic acid in a 12-month trial in obese humans. Food Chem Toxicol 2004; 42: 1701-1709. (Pubitemid 39078517)