Dorsal spinal cord stimulation obtunds the capacity of intrathoracic extracardiac neurons to transduce myocardial ischemia

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 297, Issue 2, 2009, Pages

  Ardell, Jeffrey L ^a   Cardinal, René ^b   Vermeulen, Michel ^b   Armour, J Andrew ^b  

^a EAST TENNESSEE STATE UNIVERSITY   (United States)

^b HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

Author keywords

Cardiac nervous system; Cardiac pacing; Middle cervical ganglion neuron; Neurocardiology; Ventricular ischemia

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CERVICAL GANGLION; DOG; ELECTROSTIMULATION; FEMALE; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART STRESS; HEART VENTRICLE PACING; MALE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD STIMULATION;

ACTION POTENTIALS; ANIMALS; BLOOD PRESSURE; CARDIAC PACING, ARTIFICIAL; CORONARY OCCLUSION; DOGS; ELECTRIC STIMULATION; FEMALE; GANGLIA, SYMPATHETIC; HEART; HEART RATE; HEART VENTRICLES; MALE; MYOCARDIAL ISCHEMIA; NEURAL PATHWAYS; NEURONS; PERICARDIUM; PHYSICAL STIMULATION; SPINAL CORD; VENTRICULAR FUNCTION;

EID: 68049111661     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90821.2008     Document Type: Article

References (43)

1. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
2. Andresen MC, Kunze DL, Mendelowitz D. Central nervous system regulation of the heart. In: Basic and Clinical Neurocardiology, edited by Armour JA and Ardell JL. New York: Oxford University Press, 2004, p. 187-219.
3. Ardell JL. Intrathoracic neuronal regulation of cardiac function. In: Basic and Clinical Neurocardiology, edited by Armour JA and Ardell JL. New York: Oxford University Press, 2004, p. 118-152.
4. Ardell JL, Butler CK, Smith FM, Hopkins DA, Armour JA. Activity of in vivo atrial and ventricular neurons in chronic decentralized canine hearts. Am J Physiol Heart Circ Physiol 260: H713-H721, 1991.
5. Armour JA. Synaptic transmission in chronically decentralized middle cervical and stellate ganglia of the dog. Can J Physiol Pharmacol 61: 1149-1155, 1983.
6. Armour JA. Activity of in situ middle cervical ganglion neurons in dogs, using extracellular recording techniques. Can J Physiol Pharmacol 63: 704-716, 1985.
7. Armour JA. Neuronal activity recorded extracellularly in chronic decentralized in situ canine middle cervical ganglia. Can J Physiol Pharmacol 64: 1038-1046, 1986.
8. Armour JA. Anatomy and function of the intrathoracic neurons regulating the mammalian heart. In: Reflex Control of the Circulation, edited by Zucker IH and Gilmore JP. Boca Raton, Fl: CRC, 1991, p. 1-37.
9. Armour JA. Cardiac neuronal hierarchy in health and disease. Am J Physiol Regul Integr Comp Physiol 287: R262-R271, 2004.
10. Armour JA. Potential clincial relevance of the 'little brain' on the mammalian heart. Exp Physiol 93: 165-176, 2008.
11. Armour JA, Collier K, Kember G, Ardell JL. Differential selectivity of cardiac neurons in separate intrathoracic autonomic ganglia. Am J Physiol Regul Integr Comp Physiol 274: R939-R949, 1998.
12. Armour JA, Kember G. Cardiac sensory neurons. In: Basic and Clinical Neurocardiology, edited by Armour JA and Ardell JL. New York: Oxford University Press, 2004, p. 79-117.
13. Armour JA, Linderoth B, Arora RC, DeJongste MJL, Ardell JL, Kingma JG, Hill M, Foreman RD. Long-term modulation of the intrinsic cardiac nervous system by spinal cord neurons in normal and ischemic hearts. Auton Neurosci 95: 71-79, 2002.
14. Cardinal R, Ardell JL, Linderoth B, Vermeulen M, Foreman RD, Armour JA. Spinal cord activation differentially modulates ischemic electrical responses to different stressors in canine ventricles. Auton Neurosci 111: 37-47, 2004.
15. Cardinal R, Pagé PL, Vermeulen M, Bouchard C, Ardell JL, Foreman RD, Armour JA. Spinal cord stimulation suppresses bradycardias and atrial tachyarrhythmias induced by mediastinal nerve stimulation in dogs. Am J Physiol Regul Integr Comp Physiol 291: R1369-R1375, 2006.
16. Dell'Italia LJ, Ardell JL. Sympathetic nervous system in the evolution of heart failure. In: Basic and Clinical Neurocardiology, edited by Armour JA and Ardell JL. New York: Oxford University Press, 2004, p. 340-367.
17. Ding XH, Ardell JL, Hua F, McAuley RJ, Sutherly K, Daniel JJ, Williams CA. Modulation of cardiac ischemia-sensitive afferent neuron signaling by preemptive C2 spinal cord stimulation: effect on substance P release. Am J Physiol Regul Integr Comp Physiol 294: R93-R101, 2008.
18. Ding XH, Hau F, Sutherly K, Ardell JL, Williams CA. C2 spinal cord stimulation induces dynorphin release from the rat T4 spinal cord: potential modulation of ischemia-sensitive neurons. Am J Physiol Regul Integr Comp Physiol 295: R1519-R1528, 2008.
19. Eddicks S, Maier-Hauff K, Schenk M, Mü ller A, Baumann G, Theres H. Thoracic spinal cord stimulation improves functional status and relieves symptoms in patients with refractory angina pectoris: the first placebo-controlled randomized study. Heart 93: 585-590, 2007.
20. Foreman RD, DeJongste MJL, Linderoth B. Integrative control of cardiac function by cervical and thoracic spinal neurons. In: Basic and Clinical Neurocardiology, edited by Armour JA and Ardell JL. New York: Oxford University Press, 2004, p. 153-186.
21. Foreman RD, Linderoth B, Ardell JL, Barron KW, Chandler MJ, Hull SS, TerHorst GJ, DeJongste MJL, Armour JA. Modulation of intrinsic cardiac neurons by spinal cord stimulation: implications for therapeutic use in angina pectoris. Cardiovasc Res 47: 367-375, 2000.
22. Foreman RD, Linderoth B, DeJongste MJL, Ardell JL, Armour JA. Central and peripheral mechanisms evoked by spinal cord stimulation (SCS) for angina pectoris. In: Management of Acute and Chronic Pain, edited by Krames E and Reig E. Bologna, Italy: Monduzzi Editore, 2000, p. 597-604.
23. Hautvast RW, DeJongste MJL, Staal MJ, Van Gilst VH, Lie KI. Spinal cord stimulation in chronic intractable angina pectoris: a randomized, controlled efficacy study. Am Heart J 136: 114-120, 1998.
24. Hopkins DA, Armour JA. Localization of sympathetic postganglionic and parasympathetic preganglionic neurons which innervate different regions of the dog heart. J Comp Neurol 229: 186-198, 1984.
25. Hopkins DA, Armour JA. Ganglionic distribution of afferent neurons innervating the canine heart and cardiopulmonary nerves. J Auton Nerv Syst 26: 213-222, 1989.
26. Hou Y, Scherlag BJ, Lin J, Zhang Y, Lu Z, Truong K, Patterson E, Lazzara R, Jackman WM, Po SS. Ganglionated plexi modulate extrinsic cardiac neuronal input. J Am Coll Cardiol 50: 61-68, 2007.
27. Issa ZF, Zhou X, Ujhelyi MR, Rosenberger J, Bhakta D, Groh WJ, Miller JM, Zipes DP. Thoracic spinal cord stimulation reduces the risk of ischemic ventricular arrhythmias in a post-infarction heart failure canine model. Circulation 111: 3217-3220, 2005.
28. Kember G, Fenton GA, Armour JA, Kalyaniwalla N. Competition model for aperiodic stochastic resonance in a Fitzhugh-Nagumo model of cardiac sensory neurons. Phys Rev E Stat Nonlin Soft Matter Phys 63: 1-6, 2001.
29. Kim MC, Kini A, Sharma SK. Refractory angina pectoris: mechanism and therapeutic options. J Am Coll Cardiol 39: 923-934, 2002.
30. La Rovere MT, Bersano C, Gnemmi M, Specchia G, Schwartz PJ. Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infaction. Circulation 106: 945-949, 2002.
31. Lemola K, Chartier D, Yeh YH, Dubuc M, Cartier R, Armour JA, Ting M, Sakabe M, Shiroshita-Takeshita A, Comtois P, Nattel S. Pulmonary vein region ablation in experimental vagal atrial fibrillation: role of pulmonary veins versus autonomic ganglia. Circulation 117: 470-477, 2008.
32. Mannheimer C, Camici P, Chester MR, Collins A, DeJongste MJL, Eliasson T, Follath F, Hellemans I, Herlitz J, Luscher T, Pasic M, Thelle D. The problem of chronic refractory angina: report from the ESC Joint Study Group on Treatment of Refractory Angina. Eur Heart J 23: 355-370, 2002.
33. Mannheimer C, Eliasson T, Andersson B, Bergh CH, Augustinsson LE, Emanuelsson H, Waagstein F. Effects of spinal cord stimulation in angina pectoris induced by pacing and possible mechanisms of action. Br Med J 307: 477-480, 1993.
34. Olgin JE, Takahashi T, Wilson E, Vereckei A, Steinberg H, Zipes DP. Effects of thoracic spinal cord stimulation on cardiac autonomic regulation of the sinus and atrioventricular nodes. J Cardiov Electrophysiol 13: 475-481, 2002.
35. Qin C, Farber JP, Linderoth B, Shahid A, Foreman RD. Neuromodulation of thoracic intraspinal visceroreceptive transmission by electrical stimulation of spinal cord dorsal column and somatic afferents in rats. J Pain 9: 71-78, 2008.
36. Richer LP, Vinet A, Kus T, Cardinal R, Ardell JL, Armour JA. α-Adrenoceptor blockade modifies neurally induced atrial arrhythmias. Am J Physiol Regul Integr Comp Physiol 295: R1175-R1180, 2008.
37. Southerland EM, Milhorn D, Foreman RD, Linderoth B, DeJongste MJL, Armour JA, Subramanian V, Singh M, Singh K, Ardell JL. Preemptive, but not reactive, spinal cord stimulation mitigates transient ischemia-induced infarction via cardiac adrenergic neurons. Am J Physiol Heart Circ Physiol 292: H311-H317, 2007.
38. Squire I. Neurohumoral intervention to reduce sudden cardiac death in heart failure: what is the optimal pharmacological strategy? Heart Fail Rev 9: 337-345, 2004.
39. 1-adrenergic receptor blockade attenuates angiotensin II-mediated catecholamine release into the cardiac interstitium in mitral regurgitation. Circulation 108: 225-230, 2003.
40. Vanoli E, Adamson PB, Foreman RD, Schwartz PJ. Prediction of unexpected sudden death among healthy dogs by a novel marker of autonomic neural activity. Heart Rhythm 5: 300-305, 2008.
41. Waldmann M, Thompson GW, Kember G, Ardell JL, Armour JA. Stochastic behavior of atrial and ventricular intrinsic cardiac neurons. J Appl Physiol 101: 1-7, 2006.
42. Westfall TC, Westfall DP. Adrenergic agonists and antagonists. In: Goodman & Gilman's: The Pharmacolgoical Basis of Therapeutics, edited by Brunton LL, Lazo JS, and Parker KL. New York: McGraw-Hill, 2006, p. 237-295.
43. Wu M, Linderoth B, Foreman RD. Putative mechanisms behind effects of spinal cord stimulation on vascular diseases: a review of experimental studies. Auton Neurosci 138: 9-23, 2008.