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Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: A prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis
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The effect of first-line imatinib interim therapy on the outcome of allogeneic stem cell transplantation in adults with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia
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Dasatinib (Sprycel®) and chemotherapy for first-line treatment in elderly patients with de novo Philadelphia positive ALL: Results of the first 22 patients included in the EWALL-Ph-01 Trial (on Behalf of the European Working Group on Adult ALL (EWALL))
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Rousselot P, Cayuela JM, Recher C, et al. Dasatinib (Sprycel®) and chemotherapy for first-line treatment in elderly patients with de novo Philadelphia positive ALL: results of the first 22 patients included in the EWALL-Ph-01 Trial (on Behalf of the European Working Group on Adult ALL (EWALL)). Blood 2008; 112:1004a. [Abstract 2920].
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Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation
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19
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High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance
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Branford S, Rudzki Z, Walsh S, et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood 2002; 99:3472-3475.
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Contribution of ABL kinase domain mutations to imatinib resistance in different subsets of Philadelphia-positive patients
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21
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Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia
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Hofmann WK, Komor M, Wassmann B, et al. Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia. Blood 2003; 102:659-661.
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Hofmann, W.K.1
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22
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68049091531
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Philadelphia-positive acute lymphoblastic leukemia patients already harbor bcr-abl kinase domain mutations at low levels at the time of diagnosis - a report by the GIMEMA ALL Working Party
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Abstract 722
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Soverini S, Martinelli G, Vitale A, et al. Philadelphia-positive acute lymphoblastic leukemia patients already harbor bcr-abl kinase domain mutations at low levels at the time of diagnosis - a report by the GIMEMA ALL Working Party. Blood 2008; 112:268a. [Abstract 722].
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Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)
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Pfeifer H, Wassmann B, Pavlova A, et al. Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL). Blood 2007; 110:727-734.
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Pfeifer, H.1
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78649513225
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Efficacy of allogeneic hematopoietic stem cell transplantation during first complete remission following imatinib-combined chemotherapy in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
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25
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68049100831
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Minimal residual disease and mutational status prior to and after SCT for patients with Philadelphia-chromosome-positive acute lymphoblastic leukemia (Ph+ ALL)
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Abstract 702
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Early molecular response to posttransplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)
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