Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation

Arthritis and Rheumatism

Volumn 60, Issue 8, 2009, Pages 2257-2261

  Baggott, Joseph E ^a   Morgan, Sarah L ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYMETHOTREXATE; ALDEHYDE OXIDASE; FOLIC ACID; FOLINIC ACID; METHOTREXATE;

ARTICLE; CLINICAL ARTICLE; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG RETENTION; DRUG URINE LEVEL; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; PAIN; PHENOTYPE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SWELLING; VITAMIN SUPPLEMENTATION;

ALDEHYDE OXIDASE; ARTHRITIS, RHEUMATOID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FOLIC ACID; HEALTH STATUS; HUMANS; JOINTS; LEUCOVORIN; METHOTREXATE; PAIN; TANDEM MASS SPECTROMETRY; TREATMENT OUTCOME;

EID: 68049100307     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24685     Document Type: Article

References (15)

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