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Volumn 52, Issue 1, 2005, Pages 356-358

Evidence for two phenotypes in the metabolism of methotrexate to 7-hydroxymethotrexate in patients with rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYMETHOTREXATE; ALDEHYDE OXIDASE; BENZALDEHYDE; METHOTREXATE; N METHYLNICOTINAMIDE; POLYGLUTAMIC ACID;

EID: 12344279813     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.20742     Document Type: Article
Times cited : (10)

References (14)
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    • Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone
    • Oxford
    • Fox RI, Morgan SL, Smith HT, Robbins BA, Choc MG, Baggott JE. Combined oral cyclosporin and methotrexate therapy in patients with rheumatoid arthritis elevates methotrexate levels and reduces 7-hydroxymethotrexate levels when compared with methotrexate alone. Rheumatology (Oxford) 2003;42:989-94.
    • (2003) Rheumatology , vol.42 , pp. 989-994
    • Fox, R.I.1    Morgan, S.L.2    Smith, H.T.3    Robbins, B.A.4    Choc, M.G.5    Baggott, J.E.6
  • 3
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    • Hydroxylation of 4-amino-antifolates by partially purified aldehyde oxidase from rabbit liver
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    • Fabre, G.1    Seither, R.2    Goldman, I.D.3
  • 4
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    • Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: A comparison with hepatic enzyme from guinea pig, rabbit, and baboon
    • Beedham C, Critchley DJ, Rance DJ. Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon. Arch Biochem Biophys 1995;319:481-90.
    • (1995) Arch Biochem Biophys , vol.319 , pp. 481-490
    • Beedham, C.1    Critchley, D.J.2    Rance, D.J.3
  • 5
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    • Isolation and characterization of the human aldehyde oxidase gene: Conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin
    • Terao M, Kurosaki M, Demontis S, Zanotta S, Garattini E. Isolation and characterization of the human aldehyde oxidase gene: conservation of intron/exon boundaries with the xanthine oxidoreductase gene indicates a common origin. Biochem J 1998;332:383-93.
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    • Terao, M.1    Kurosaki, M.2    Demontis, S.3    Zanotta, S.4    Garattini, E.5
  • 7
    • 0027526252 scopus 로고
    • The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis
    • Seideman P, Beck O, Eksborg S, Wennberg M. The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis. Br J Clin Pharmacol 1993;35:409-12.
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 409-412
    • Seideman, P.1    Beck, O.2    Eksborg, S.3    Wennberg, M.4
  • 10
    • 0023026453 scopus 로고
    • Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in plasma and bone marrow of children receiving low-dose oral methotrexate
    • Sonneveld P, Schultz FW, Nooter K, Hahlen K. Pharmacokinetics of methotrexate and 7-hydroxy-methotrexate in plasma and bone marrow of children receiving low-dose oral methotrexate. Cancer Chemother Pharmacol 1986;18:111-6.
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    • Sonneveld, P.1    Schultz, F.W.2    Nooter, K.3    Hahlen, K.4
  • 11
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    • Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro
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    • Rodrigues, A.D.1
  • 12
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    • Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver
    • Sugihara K, Kitamura S, Tatsumi K, Asahara T, Dohi K. Differences in aldehyde oxidase activity in cytosolic preparations of human and monkey liver. Biochem Mol Biol Int 1997;41:1153-60.
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  • 13
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    • Baggott, J.E.1    Morgan, S.L.2    Koopman, W.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.