Antitumor treatment using interleukin-12-secreting marrow stromal cells in an invasive glioma model

Neurosurgery

Volumn 64, Issue 6, 2009, Pages 1139-1146

  Hong, Xin ^a   Miller, Cathie ^a   Savant Bhonsale, Smita ^b   Kalkanis, Steven N ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b Theradigm Inc   (United States)

Author keywords

Animal model; Glioma; Interleukin 12; Invasion; Marrow stromal cells

Indexed keywords

ADENOVIRUS VECTOR; CD57 ANTIGEN; RECOMBINANT INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CANCER GENE THERAPY; CANCER IMMUNOTHERAPY; CANCER INVASION; CD3+ T LYMPHOCYTE; CELL TRANSPLANTATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GLIOBLASTOMA; GLIOMA; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; TUMOR XENOGRAFT; Y CHROMOSOME;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD3; ANTIGENS, CD57; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; CELL LINE, TUMOR; DACTINOMYCIN; DISEASE MODELS, ANIMAL; FLOW CYTOMETRY; GLIOMA; INTERLEUKIN-12; KAPLAN-MEIERS ESTIMATE; KILLER CELLS, NATURAL; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; STROMAL CELLS; TIME FACTORS; Y CHROMOSOME;

EID: 68049097118     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000345646.85472.EA     Document Type: Article

References (20)

1. Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Ourednik V, Black PM, Breakefield XO, Snyder EY: Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas. Proc Natl Acad Sci U S A 97:12846-12851, 2000. (Pubitemid 30840504)
2. Azizi SA, Stokes D, Augelli BJ, DiGirolamo C, Prockop DJ: Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats- similarities to astrocyte grafts. Proc Natl Acad Sci U S A 95:3908-3913, 1998. (Pubitemid 28173227)
3. Benedetti S, Pirola B, Pollo B, Magrassi L, Bruzzone MG, Rigamonti D, Galli R, Selleri S, Di Meco F, De Fraja C, Vescovi A, Cattaneo E, Finocchiaro G: Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 6:447-450, 2000. (Pubitemid 30208163)
4. Bögler O, Huang HJ, Cavenee WK: Loss of wild- type p53 bestows a growth advantage on primary cortical astrocytes and facilitates their in vitro transformation. Cancer Res 55:2746-2751, 1995.
5. Chopp M, Li Y: Treatment of neural injury with marrow stromal cells. Lancet Neurol 1:92-100, 2002. (Pubitemid 37163494)
6. Cohen J: IL-12 deaths: Explanation and a puzzle. Science 270:908, 1995.
7. Ehtesham M, Kabos P, Kabosova A, Neuman T, Black KL, Yu JS: The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma. Cancer Res 62:5657-5663, 2002. (Pubitemid 35204717)
8. Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, Teng YD, Frenkel D, Li J, Sidman RL, Walsh CA, Snyder EY, Khoury SJ: Directed migration of neural stem cells to sites of CNS injury by the stromal cell- derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc Natl Acad Sci U S A 101:18117-18122, 2004. (Pubitemid 40054083)
9. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G: Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170:827-845, 1989. (Pubitemid 19226667)
10. Leonard JP, Sherman ML, Fisher GL, Buchanan LJ, Larsen G, Atkins MB, Sosman JA, Dutcher JP, Vogelzang NJ, Ryan JL: Effects of single- dose interleukin- 12 exposure on interleukin-12-associated toxicity and interferongamma production. Blood 90:2541-2548, 1997.
11. Li Y, McIntosh K, Chen J, Zhang C, Gao Q, Borneman J, Raginski K, Mitchell J, Shen L, Zhang J, Lu D, Chopp M: Allogeneic bone marrow stromal cells promote glial- axonal remodeling without immunologic sensitization after stroke in rats. Exp Neurol 198:313-325, 2006.
12. Lu M, Chen J, Lu D, Yi L, Mahmood A, Chopp M: Global test statistics for treatment effect of stroke and traumatic brain injury in rats with administration of bone marrow stromal cells. J Neurosci Methods 128:183-190, 2003. (Pubitemid 37013561)
13. Mahmood A, Lu D, Chopp M: Marrow stromal cell transplantation after traumatic brain injury promotes cellular proliferation within the brain. Neurosurgery 55:1185-1193, 2004. (Pubitemid 39525223)
14. Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J, Chen J, Hentschel S, Vecil G, Dembinski J, Andreeff M, Lang FF: Human bone marrow- derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 65:3307-3318, 2005. (Pubitemid 40524615)
15. Nakamura K, Ito Y, Kawano Y, Kurozumi K, Kobune M, Tsuda H, Bizen A, Honmou O, Niitsu Y, Hamada H: Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther 11:1155-1164, 2004. (Pubitemid 39117311)
16. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147, 1999. (Pubitemid 29282067)
17. Prockop DJ, Azizi SA, Phinney DG, Kopen GC, Schwarz EJ: Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system. Prog Brain Res 128:293-297, 2000. (Pubitemid 35461245)
18. Trinchieri G, Gerosa F: Immunoregulation by interleukin-12. J Leukoc Biol 59:505-511, 1996.
19. Trinchieri G, Rengaraju M, D'Andrea A, Valiante NM, Kubin M, Aste M, Chehimi J: Producer cells of interleukin-12. Immunol Today 14:237-238, 1993.
20. Zhang R, Zhang Z, Wang L, Wang Y, Gousev A, Zhang L, Ho KL, Morshead C, Chopp M: Activated neural stem cells contribute to stroke- induced neurogenesis and neuroblast migration toward the infarct boundary in adult rats. J Cereb Blood Flow Metab 24:441-448, 2004. (Pubitemid 38452235)