Serum transferrin receptors: Distribution and diagnostic performance in pre-school children

Blood Cells, Molecules, and Diseases

Volumn 43, Issue 2, 2009, Pages 163-168

  Chouliaras, Giorgos L ^a   Premetis, Evangelos ^b   Tsiftis, George ^a   Drosatou, Panayiota ^a   Papassotiriou, Ioannis ^b   Stamoulakatou, Alexandra ^b   Lycopoulou, Lilia ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

Author keywords

Iron deficiency; Reference range; Thalassemia trait; Transferrin receptors

Indexed keywords

FERRITIN; HEMOGLOBIN A2; TRANSFERRIN RECEPTOR;

AGE; ARTICLE; BETA THALASSEMIA; CHILD; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; HUMAN; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCREENING TEST; SENSITIVITY AND SPECIFICITY;

ANEMIA, IRON-DEFICIENCY; BETA-THALASSEMIA; CHILD; CHILD, PRESCHOOL; FEMALE; FERRITINS; HEMOGLOBINS; HUMANS; INFANT; MALE; RECEPTORS, TRANSFERRIN; SENSITIVITY AND SPECIFICITY;

EID: 68049084848     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2009.03.007     Document Type: Article

References (35)

1. Baynes R.D., Shih Y.J., and Cook J.D. Mechanism of production of the serum transferrin receptor. Adv. Exp. Med. Biol. 356 (1994) 61-68
2. Dimitriou H., Stiakaki E., Markaki E.A., Bolonaki I., Giannakopoulou C., and Kalmanti M. Soluble transferrin receptor levels and soluble transferrin receptor/log ferritin index in the evaluation of erythropoietic status in childhood infections and malignancy. Acta Paediatr. 89 10 (2000 Oct) 1169-1173
3. Feelders R.A., Kuiper-Kramer E.P., and van Eijk H.G. Structure, function and clinical significance of transferrin receptors. Clin. Chem. Lab. Med. 37 1 (1999 Jan) 1-10
4. Halterman J.S., Kaczorowski J.M., Aligne C.A., Auinger P., and Szilagyi P.G. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics 107 6 (2001 Jun) 1381-1386
5. McCann J.C., and Ames B.N. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am. J. Clin. Nutr. 85 4 (2007 Apr) 931-945
6. Suominen P., Punnonen K., Rajamaki A., and Irjala K. Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood 92 8 (1998 Oct 15) 2934-2939
7. Sandoval C., Jayabose S., and Eden A.N. Trends in diagnosis and management of iron deficiency during infancy and early childhood. Hematol. Oncol. Clin. North Am. 18 6 (2004 Dec) 1423-1438 x
8. Grant C.C., Wall C.R., Brewster D., Nicholson R., Whitehall J., Super L., et al. Policy statement on iron deficiency in pre-school-aged children. J. Paediatr. Child Health 43 7-8 (2007 Jul-Aug) 513-521
9. WHO/UNICEF/UNU. Iron deficiency anemia: assessment, prevention, and control. Geneva: World Health Organization; 2001 [updated 2001; cited]; Available from: http://www.who.int/nutrition/publications/micronutrients/anemia_iron_deficiency/en/ida_assessment_prevention_control.pdf.
10. Kattamis C., Metaxotou-Mavromati A., Wood W.G., Nash J.R., and Weatherall D.J. The heterogeneity of normal Hb A2-beta thalassaemia in Greece. Br. J. Haematol. 42 1 (1979 May) 109-123
11. Suominen P., Virtanen A., Lehtonen-Veromaa M., Heinonen O.J., Salmi T.T., Alanen M., et al. Regression-based reference limits for serum transferrin receptor in children 6 months to 16 years of age. Clin. Chem. 47 5 (2001 May) 935-937
12. Kratovil T., DeBerardinis J., Gallagher N., Luban N.L., Soldin S.J., and Wong E.C. Age specific reference intervals for soluble transferrin receptor (sTfR). Clin. Chim. Acta 380 1-2 (2007 May 1) 222-224
13. Yeung G.S., and Zlotkin S.H. Percentile estimates for transferrin receptor in normal infants 9-15 mo of age. Am. J. Clin. Nutr. 66 2 (1997 Aug) 342-346
14. Danise P., Maconi M., Morelli G., Di Palma A., Rescigno G., Esposito C., et al. Reference limits and behaviour of serum transferrin receptor in children 6-10 years of age. Int. J. Lab. Hematol. 30 4 (2008 Aug) 306-311
15. Virtanen M.A., Viinikka L.U., Virtanen M.K., Svahn J.C., Anttila R.M., Krusius T., et al. Higher concentrations of serum transferrin receptor in children than in adults. Am. J. Clin. Nutr. 69 2 (1999 Feb) 256-260
16. Raya G., Henny J., Steinmetz J., Herbeth B., and Siest G. Soluble transferrin receptor (sTfR): biological variations and reference limits. Clin. Chem. Lab. Med. 39 11 (2001 Nov) 1162-1168
17. Choi J.W., Pai S.H., Im M.W., and Kim S.K. Change in transferrin receptor concentrations with age. Clin. Chem. 45 9 (1999 Sep) 1562-1563
18. Olivares M., Walter T., Cook J.D., Hertrampf E., and Pizarro F. Usefulness of serum transferrin receptor and serum ferritin in diagnosis of iron deficiency in infancy. Am. J. Clin. Nutr. 72 5 (2000 Nov) 1191-1195
19. Thomas C., and Thomas L. Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency. Clin. Chem. 48 7 (2002 Jul) 1066-1076
20. Lin X.M., Ji C.Y., Liu W.J., Long Z., and Shen X.Y. Levels of serum transferrin receptor and its response to Fe-supplement in Fe-deficient children. Br. J. Nutr. 96 6 (2006 Dec) 1134-1139
21. Domellof M., Lonnerdal B., Dewey K.G., Cohen R.J., Rivera L.L., and Hernell O. Sex differences in iron status during infancy. Pediatrics 110 3 (2002 Sep) 545-552
22. Domellof M., Dewey K.G., Lonnerdal B., Cohen R.J., and Hernell O. The diagnostic criteria for iron deficiency in infants should be reevaluated. J. Nutr. 132 12 (2002 Dec) 3680-3686
23. Cook J.D., Flowers C.H., and Skikne B.S. The quantitative assessment of body iron. Blood. 101 9 (2003 May 1) 3359-3364
24. Skikne B.S., Flowers C.H., and Cook J.D. Serum transferrin receptor: a quantitative measure of tissue iron deficiency. Blood. 75 9 (1990 May 1) 1870-1876
25. Punnonen K., Irjala K., and Rajamaki A. Iron-deficiency anemia is associated with high concentrations of transferrin receptor in serum. Clin. Chem. 40 5 (1994 May) 774-776
26. Choi J.W., and Pai S.H. Associations between serum transferrin receptor concentrations and erythropoietic activities according to body iron status. Ann. Clin. Lab. Sci. 33 3 (2003 Summer) 279-284
27. Skarmoutsou C., Papassotiriou I., Traeger-Synodinos J., Stamou H., Ladis V., Metaxotou-Mavrommati A., et al. Erythroid bone marrow activity and red cell hemoglobinization in iron sufficient beta-thalassemia heterozygotes as reflected by soluble transferrin receptor and reticulocyte hemoglobin in content. Correlation with genotypes and Hb A(2) levels. Haematologica 88 6 (2003 Jun) 631-636
28. Huebers H.A., Beguin Y., Pootrakul P., Einspahr D., and Finch C.A. Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 75 1 (1990 Jan 1) 102-107
29. Beguin Y., Clemons G.K., Pootrakul P., and Fillet G. Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin. Blood 81 4 (1993 Feb 15) 1067-1076
30. Rees D.C., Williams T.N., Maitland K., Clegg J.B., and Weatherall D.J. Alpha thalassaemia is associated with increased soluble transferrin receptor levels. Br. J. Haematol. 103 2 (1998 Nov) 365-369
31. Vazquez Lopez M.A., Carracedo A., Lendinez F., Munoz F.J., Lopez J., and Munoz A. The usefulness of serum transferrin receptor for discriminating iron deficiency without anemia in children. Haematologica 91 2 (2006 Feb) 264-265
32. Malope B.I., MacPhail A.P., Alberts M., and Hiss D.C. The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status. Br. J. Haematol. 115 1 (2001 Oct) 84-89
33. Choi J.W. Sensitivity, specificity, and predictive value of serum soluble transferrin receptor at different stages of iron deficiency. Ann. Clin. Lab. Sci. 35 4 (2005 Autumn) 435-439
34. Looker A.C., Dallman P.R., Carroll M.D., Gunter E.W., and Johnson C.L. Prevalence of iron deficiency in the United States. JAMA 277 12 (1997 Mar 26) 973-976
35. Kanavakis E., Tzotzos S., Liapaki A., Metaxotou-Mavromati A., and Kattamis C. Frequency of alpha-thalassemia in Greece. Am. J. Hematol. 22 3 (1986 Jul) 225-232