Mechanosensitive promoter region in the human HB-GAM gene

Biochemical and Biophysical Research Communications

Volumn 387, Issue 2, 2009, Pages 289-293

  Liedert, Astrid ^a   Kassem, Moustapha ^b   Claes, Lutz ^a   Ignatius, Anita ^a  

^a UNIVERSITY OF ULM   (Germany)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Heparin binding growth associated molecule; Mechanical loading; Mechanosensitivity; Mesenchymal stem cell; Promoter; Transcription

Indexed keywords

LUCIFERASE; PLEIOTROPHIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BINDING SITE; BONE MARROW; CELL LINE; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HB GAM GENE; HUMAN; HUMAN CELL; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSCRIPTION REGULATION; UPREGULATION;

BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; CYTOKINES; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LUCIFERASES; MECHANOTRANSDUCTION, CELLULAR; OSTEOGENESIS; PROMOTER REGIONS, GENETIC; SEQUENCE DELETION; TRANSCRIPTION FACTOR AP-1;

EID: 67949118679     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.07.002     Document Type: Article

References (29)

1. Turner C.H. Bone strength: current concepts. Ann. NY Acad. Sci. 1068 (2006) 429-446
2. Park J.S., Huang N.F., Kurpinski K.T., Patel S., Hsu S., and Li S. Mechanobiology of mesenchymal stem cells and their use in cardiovascular repair. Front. Biosci. 12 (2007) 5098-5116
3. Braddock M., Schwachtgen J.L., Houston P., Dickson M.C., Lee M.J., and Campbell C.J. Fluid shear stress modulation of gene expression in endothelial cells. News Physiol. Sci. 13 (1998) 241-246
4. Rauvala H. An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors. EMBO J. 8 (1989) 2933-2941
5. Imai S., Kaksonen M., Raulo E., Kinnunen T., Fages C., Meng X., Lakso M., and Rauvala H. Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM). J. Cell Biol. 143 (1998) 1113-1128
6. Masuda H., Tsujimura A., Yoshioka M., Arai Y., Kuboki Y., Mukai T., Nakamura T., Tsuji H., Nakagawa M., and Hashimoto-Gotoh T. Bone mass loss due to estrogen deficiency is compensated in transgenic mice overexpressing human osteoblast stimulating factor-1. Biochem. Biophys. Res. Commun. 238 (1997) 528-533
7. Tare R.S., Oreffo R.O., Clarke N.M., and Roach H.I. Pleiotrophin/osteoblast-stimulating factor 1: dissecting its diverse functions in bone formation. J. Bone Miner. Res. 17 (2002) 2009-2020
8. Li G., Bunn J.R., Mushipe M.T., He Q., and Chen X. Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair. Calcif. Tissue Int. 76 (2005) 299-306
9. Liedert A., Augat P., Ignatius A., Hausser H.J., and Claes L. Mechanical regulation of HB-GAM expression in bone cells. Biochem. Biophys. Res. Commun. 319 (2004) 951-958
10. Xing W., Baylink D., Kesavan C., Hu Y., Kapoor S., Chadwick R.B., and Mohan S. Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice. J. Cell. Biochem. 96 (2005) 1049-1060
11. Imai S., Heino T.J., Hienola A., Kurata K., Buki K., Matsusue Y., Vaananen H.K., and Rauvala H. Osteocyte-derived HB-GAM (pleiotrophin) is associated with bone formation and mechanical loading. Bone 44 (2009) 785-794
12. Simonsen J.L., Rosada C., Serakinci N., Justesen J., Stenderup K., Rattan S.I., Jensen T.G., and Kassem M. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat. Biotechnol. 20 (2002) 592-596
13. Neidlinger-Wilke C., Wilke H.J., and Claes L. Cyclic stretching of human osteoblasts affects proliferation and metabolism: a new experimental method and its application. J. Orthop. Res. 12 (1994) 70-78
14. Liedert A., Kaspar D., Claes L., and Ignatius A. Signal transduction pathways involved in mechanical regulation of HB-GAM expression in osteoblastic cells. Biochem. Biophys. Res. Commun. 342 (2006) 1070-1076
15. Li Y.S., Hoffman R.M., Le Beau M.M., Espinosa III R., Jenkins N.A., Gilbert D.J., Copeland N.G., and Deuel T.F. Characterization of the human pleiotrophin gene. Promoter region and chromosomal localization. J. Biol. Chem. 267 (1992) 26011-26016
16. Petersen W., Wildemann B., Pufe T., Raschke M., and Schmidmaier G. The angiogenic peptide pleiotrophin (PTN/HB-GAM) is expressed in fracture healing: an immunohistochemical study in rats. Arch. Orthop. Trauma Surg. 124 (2004) 603-607
17. Stock M., Schafer H., Fliegauf M., and Otto F. Identification of novel genes of the bone-specific transcription factor Runx2. J. Bone Miner. Res. 19 (2004) 959-972
18. Yang X., Tare R.S., Partridge K.A., Roach H.I., Clarke N.M., Howdle S.M., Shakesheff K.M., and Oreffo R.O. Induction of human osteoprogenitor chemotaxis, proliferation, differentiation, and bone formation by osteoblast stimulating factor-1/pleiotrophin: osteoconductive biomimetic scaffolds for tissue engineering. J. Bone Miner. Res. 18 (2003) 47-57
19. Dreyfus J., Brunet-de Carvalho N., Duprez D., Raulais D., and Vigny M. HB-GAM/pleiotrophin: localization of mRNA and protein in the chicken developing leg. Int. J. Dev. Biol. 42 (1998) 189-198
20. Zhang P., Su M., Liu Y., Hsu A., and Yokota H. Knee loading dynamically alters intramedullary pressure in mouse femora. Bone 40 (2007) 538-543
21. Knothe Tate M.L., Falls T.D., McBride S.H., Atit R., and Knothe U.R. Mechanical modulation of osteochondroprogenitor cell fate. Int. J. Biochem. Cell Biol. 40 (2008) 2720-2738
22. Nomura S., and Takano-Yamamoto T. Molecular events caused by mechanical stress in bone. Matrix Biol. 19 (2000) 91-96
23. Wagner E.F., and Eferl R. Fos/AP-1 proteins in bone and the immune system. Immunol. Rev. 208 (2005) 126-140
24. Kakisis J.D., Liapis C.D., and Sumpio B.E. Effects of cyclic strain on vascular cells. Endothelium 11 (2004) 17-28
25. Ogasawara A., Arakawa T., Kaneda T., Takuma T., Sato T., Kaneko H., Kumegawa M., and Hakeda Y. Fluid shear stress-induced cyclooxygenase-2 expression is mediated by C/EBP beta, cAMP-response element-binding protein, and AP-1 in osteoblastic MC3T3-E1 cells. J. Biol. Chem. 276 (2001) 7048-7054
26. Mora-Garcia P., Cheng J., Crans-Vargas H.N., Countouriotis A., Shankar D., and Sakamoto K.M. Transcriptional regulators and myelopoiesis: the role of serum response factor and CREB as targets of cytokine signaling. Stem Cells 21 (2003) 123-130
27. Peake M.A., and El Haj A.J. Preliminary characterisation of mechanoresponsive regions of the c-fos promoter in bone cells. FEBS Lett. 537 (2003) 117-120
28. Inoue D., Kido S., and Matsumoto T. Transcriptional induction of FosB/DeltaFosB gene by mechanical stress in osteoblasts. J. Biol. Chem. 279 (2004) 49795-49803
29. Friedl G., Schmidt H., Rehak I., Kostner G., Schauenstein K., and Windhager R. Undifferentiated human mesenchymal stem cells (hMSCs) are highly sensitive to mechanical strain: transcriptionally controlled early osteo-chondrogenic response in vitro. Osteoarthritis Cartilage 15 (2007) 1293-1300