Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: Results from the OCD collaborative genetics study

American Journal of Psychiatry

Volumn 164, Issue 3, 2007, Pages 493-499

  Samuels, Jack ^a   Yin, Yao Shugart ^b   Grados, Marco A ^b   Willour, Virginia L ^b   Bienvenu, O Joseph ^b   Greenberg, Benjamin D ^b   Knowles, James A ^b   McCracken, James T ^b   Rauch, Scott L ^b   Murphy, Dennis L ^b   Wang, Ying ^b   Pinto, Anthony ^b   Fyer, Abby J ^b   Piacentini, John ^b   Pauls, David L ^b   Cullen, Bernadette ^b   Rasmussen, Steven A ^b   Hoehn Saric, Rudolf ^b   Valle, David ^b   Liang, Kung Yee ^b   Riddle, Mark A ^b   Nestadt, Gerald ^b   more..

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; CHILD; CHROMOSOME 14; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC MARKER; GENETIC RISK; GENETIC TRAIT; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSESSIVE COMPULSIVE DISORDER; PHENOTYPE; PRIORITY JOURNAL; STRATIFICATION;

EID: 34047157648     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.2007.164.3.493     Document Type: Article

References (40)

1. Mataix-Cols D, Rosario-Campos MC, Leckman JF: A multidimensional model of obsessive-compulsive disorder. Am J Psychiatry 2005; 162:228-238
2. Miguel EC, Leckman JF, Rauch S, Rosario-Campos MC, Hounie AG, Mercadante MT, Chacon P, Pauls DL: Obsessive-compulsive disorder phenotypes: implications for genetic studies. Mol Psychiatry 2005; 10:258-275
3. Frost RO, Hartl TL: A cognitive-behavioral model of compulsive hoarding. Behav Res Ther 1996; 34:341-350
4. Frost RO, Krause MS, Steketee G: Hoarding and obsessive-compulsive symptoms. Behav Modif 1996; 20:116-132
5. Samuels J, Bienvenu OJ, Riddle MA, Cullen BAM, Grados MA, Liang KY, Hoehn-Saric R, Nestadt G: Hoarding in obsessive-compulsive disorder: results from a case-control study. Behav Res Ther 2002; 40:517-528
6. Frost RO, Steketee G, Williams LF, Warren R: Mood, personality disorder symptoms and disability in obsessive compulsive hoarders: a comparison with clinical and nonclinical controls. Behav Res Ther 2000; 38:1071-1081
7. Samuels JF, Bienvenu OJ III, Pinto A, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Greenberg BD, Knowles JA, Piacentini J, Cannistraro PA, Cullen B, Riddle MA, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G: Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Behav Res Ther (in press)
8. Black DW, Monahan P, Gable J, Blum N, Clancy G, Baker P: Hoarding and treatment response in 38 nondepressed subjects with obsessive-compulsive disorder. J Clin Psychiatry 1998; 59: 420-425
9. Mataix-Cols D, Rauch SL, Manzo PA, Jenike MA: Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. Am J Psychiatry 1999; 156:1409-1416
10. Mataix-Cols D, Marks IM, Greist JH, Kobak KA, Baer L: Obsessive-compulsive symptom dimensions as predictors of compliance with and response to behaviour therapy: results from a controlled trial: Psychother Psychosom 2002; 71:255-262
11. Saxena S, Maidment KM, Vapnik T, Golden G, Rishwain T, Rosen RM, Tarlow G, Bystritsky A: Obsessive-compulsive hoarding: symptom severity and response to multimodal treatment. J Clin Psychiatry 2002; 63:21-27
12. Shetti CN, Reddy YC, Kandavel T, Kashyap K, Singisetti S, Hiremath AS, Siddequehusen MU, Raghunandanan S: Clinical predictors of drug nonresponse in obsessive-compulsive disorder. J Clin Psychiatry 2005; 66:1517-1523
13. Saxena S, Brody AL, Maidment KM, Baxter LR: Paroxetine treatment of compulsive hoarding. J Psychiatr Res (in press)
14. Saxena S, Brody AL, Maidment KM, Smith EC, Zohrabi N, Katz E, Baker SK, Baxter LR Jr: Cerebral glucose metabolism in obsessive-compulsive hoarding. Am J Psychiatry 2004; 161:1038-1048
15. Mataix-Cols D, Wooderson S, Lawrence N, Brammer MJ, Speckens A, Phillips ML: Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry 2004; 61:564-576
16. Hasler G, Pinto A, Greenberg BD, Samuels J, Fyer AJ, Pauls D, Knowles JA, McCracken JT, Piacentini J, Riddle MA, Rauch SL, Rasmussen SA, Willour VL, Grados MA, Cullen B, Bienvenu OJ, Shugart YY, Liang KY, Hoehn-Saric R, Wang Y, Ronquillo J, Nestadt G, Murphy DL: Familiality of factor analysis-derived YBOCS dimensions in OCD affected sibling pairs from the OCD Collaborative Genetics Study. Biol Psychiatry (in press)
17. Shugart YY, Samuels J, Willour VL, Grados MA, Greenberg BD, Knowles JA, McCracken JT, Rauch SL, Murphy DL, Wang Y, Pinto A, Fyer AJ, Piacentini J, Pauls DL, Cullen B, Page J, Rasmussen SR, Bienvenu OJ, Hoehn-Saric R, Valle D, Liang KY, Riddle MA, Nestadt G: Genome-wide linkage scan for obsessive-compulsive disorder: evidence for susceptibility loci on chromosomes 3q, 7p, 15q, 6q, and 1q. Mol Psychiatry 2006; 11:763-770
18. Samuels JF, Riddle MA, Greenberg BD, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Pinto A, Knowles JA, Piacentini J, Cannistraro PA, Cullen B, Bienvenu OJ III, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G: The OCD Collaborative Genetics Study: methods and sample description. Am J Med Genet B Neuropsychiatr Genet 2006; 141:201-207
19. Fyer AJ, Mannuzza SM, Schleyer B, Aaronson C, Klein DF, Endicott J: Schedule for Affective Disorders and Schizophrenia: Life-time Anxiety Version, revised ed. New York, New York State Psychiatric Institute, 1991
20. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS: The Yale-Brown Obsessive Compulsive Scale, I: development, use, and reliability. Arch Gen Psychiatry 1989; 46:1006-1011
21. First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Edition (SCID-P). New York, New York State Psychiatric Institute, Biometrics Research, 1995
22. Mannuzza S, Fyer AJ, Endicott J, Klein DF: Family Informant Schedule and Criteria. New York, New York State Psychiatric Institute, 1985
23. Broman KW, Weber JL: Estimation of pairwise relationships in the presence of genotyping errors. Am J Hum Genet 1998; 63: 259-266
24. O'Connell JR, Weeks DE: PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998; 63:259-266
25. Douglas JA, Skol AD, Boehnke M: Probability of detection of genotyping errors and mutations as inheritance inconsistencies in nuclear-family data. Am J Hum Genet 2002; 70:487-495
26. Abecasis GR, Cherny SS, Cookson WO, Cardon LR: Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30:97-101
27. Kong A, Cox NJ: Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 1997; 61:1179-1188
28. Black DW, Noyes R Jr, Goldstein RB, Blum N: A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 1992; 49: 362-368
29. Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF: A family study of obsessive-compulsive disorder. Am J Psychiatry 1995; 152:76-84
30. Nestadt G, Samuels J, Riddle M, Bienvenu OJ, Liang KY, LaBuda M, Walkup J, Grados M, Hoehn-Saric R: A family study of obsessive compulsive disorder. Arch Gen Psychiatry 2000; 57:358-363
31. Hanna GL, Himle JA, Curtis GC, Gillespie BW: A family study of obsessive-compulsive disorder with pediatric probands. Am J Med Genet B Neuropsychiatr Genet 2005; 34:13-19
32. Nestadt G, Lan T, Samuels J, Riddle M, Bienvenu OJ, Liang KY, Hoehn-Saric R, Cullen B, Grados M, Beaty TH, Shugart YY: Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder (OCD) and heterogeneity by gender. Am J Hum Genet 2000; 67:1611-1616
33. Hanna GL, Fingerlin TE, Himle JA, Boehnke M: Complex segregation analysis of obsessive-compulsive disorder in families with pediatric probands. Hum Hered 2005; 60:1-9
34. Hanna GL, Veenstra-VanderWeele J, Cox NJ, Boehnke M, Himle JA, Curtis GC, Leventhal BL, Cook EH Jr: Genome-wide linkage analysis of families with obsessive-compulsive disorder ascertained through pediatric probands. Am J Med Genet 2002; 114:541-552
35. Kruglyak L, Lander ES: High-resolution genetic mapping of complex traits. Am J Hum Genet 1995; 56:1212-1223
36. Pulver AE, Mulle J, Nestadt G, Swartz KL, Blouin JL, Dombroski B, Liang KY, Housman DE, Kazazian HH, Antonarakis SE, Lasseter VK, Wolyniec PS, Thornquist MH, McGrath JA: Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes. Mol Psychiatry 2000; 5:650-653
37. Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS: Replication of linkage studies of complex traits: an examination of variation in location estimates. Am J Hum Genet 1999; 65:876-884
38. Zhang H, Leckman JF, Pauls DL, Tsai CP, Kidd KK, Campos MR: Tourette Syndrome Association International Consortium for Genetics: genomewide scan of hoarding in sib pairs in which both sibs have Gilles de la Tourette syndrome. Am J Hum Genet 2002; 70:896-904
39. Dykens E, Shah B: Psychiatric disorders in Prader-Willi syndrome. CNS Drugs 2003; 17:167-178
40. Gothelf D, Presburger G, Zohar AH, Burg M, Nahmani A, Frydman M, Shohat M, Inbar D, Aviram-Goldring A, Yeshaya J, Steinberg T, Finkelstein Y, Frisch A, Weizman A, Apter A: Obsessive-compulsive disorder in patients with velocardiofacial (22q11 deletion) syndrome. Am J Med Genet B Neuropsychiatr Genet 2004; 126:99-105