Quantification of free total plasma DNA and minimal residual disease detection in the plasma of children with acute lymphoblastic leukemia

Annals of Hematology

Volumn 88, Issue 9, 2009, Pages 897-905

  Schwarz, Arne Kristian ^a   Stanulla, Martin ^b   Cario, Gunnar ^b   Flohr, Thomas ^b   Sutton, Rosemary ^c   Möricke, Anja ^b   Anker, Philippe ^d   Stroun, Maurice ^d   Welte, Karl ^a   Bartram, Claus R ^e   Schrappe, Martin ^b   Schrauder, André ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c CHILDREN S CANCER INSTITUTE AUSTRALIA FOR MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF GENEVA   (Switzerland)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acute lymphoblastic leukemia; Childhood; Ig TCR gene rearrangements; Minimal residual disease; Plasma DNA

Indexed keywords

DNA; PREDNISONE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; LEUKOCYTE COUNT; MALE; MINIMAL RESIDUAL DISEASE; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ADOLESCENT; ALLELES; CHILD; CHILD, PRESCHOOL; DNA; FEMALE; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; HUMANS; INFANT; MALE; NEOPLASM, RESIDUAL; POLYMERASE CHAIN REACTION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS;

EID: 67849119165     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-009-0698-6     Document Type: Article

References (35)

1. Leon SA, Shapiro B, Sklaroff DM, Yaros MJ (1977) Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 37:646-650
2. Shapiro B, Chakrabarty M, Cohn EM, Leon SA (1983) Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease. Cancer 51:2116-2120 doi: 10.1002/ 1097-0142(19830601)51:11<2116::AID-CNCR2820511127>3.0.CO;2-S
3. Stroun M, Anker P, Lyautey J, Lederrey C, Maurice PA (1987) Isolation and characterization of DNA from the plasma of cancer patients. Eur J Cancer Clin Oncol 23:707-712 doi: 10.1016/0277-5379(87)90266-5
4. Anker P, Stroun M (2001) Tumor-related alterations in circulating DNA, potential for diagnosis, prognosis and detection of minimal residual disease. Leukemia 15:289-291 doi: 10.1038/sj.leu.2402016
5. Anker P, Lefort F, Vasioukhin V, Lyautey J, Lederrey C, Chen XQ, Stroun M, Mulcahy HE, Farthing MJ (1997) K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer. Gastroenterology 112:1114-1120 doi: 10.1016/S0016-5085(97)70121-5
6. Chen XQ, Stroun M, Magnenat JL, Nicod LP, Kurt AM, Lyautey J, Lederrey C, Anker P (1996) Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat Med 2:1033-1035 see comments doi: 10.1038/ nm0996-1033
7. Nawroz H, Koch W, Anker P, Stroun M, Sidransky D (1996) Microsatellite alterations in serum DNA of head and neck cancer patients. Nat Med 2:1035-1037 doi: 10.1038/nm0996-1035
8. Goessl C, Heicappell R, Munker R, Anker P, Stroun M, Krause H, Muller M, Miller K (1998) Microsatellite analysis of plasma DNA from patients with clear cell renal carcinoma. Cancer Res 58:4728-4732
9. Fujiwara Y, Chi DD, Wang H, Keleman P, Morton DL, Turner R, Hoon DS (1999) Plasma DNA microsatellites as tumor-specific markers and indicators of tumor progression in melanoma patients. Cancer Res 59:1567-1571
10. Esteller M, Sanchez-Cespedes M, Rosell R, Sidransky D, Baylin SB, Herman JG (1999) Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res 59:67-70
11. Wong IH, Lo YM, Zhang J, Liew CT, Ng MH, Wong N, Lai PB, Lau WY, Hjelm NM, Johnson PJ (1999) Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. Cancer Res 59:71-73
12. Silva JM, Dominguez G, Villanueva MJ, Gonzalez R, Garcia JM, Corbacho C, Provencio M, Espana P, Bonilla F (1999) Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients. Br J Cancer 80:1262-1264 doi: 10.1038/sj.bjc.6690495
13. Vasioukhin V, Anker P, Maurice P, Lyautey J, Lederrey C, Stroun M (1994) Point mutations of the N-ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia. Br J Haematol 86:774-779 doi: 10.1111/j.1365-2141.1994.tb04828.x
14. Frickhofen N, Muller E, Sandherr M, Binder T, Bangerter M, Wiest C, Enz M, Heimpel H (1997) Rearranged Ig heavy chain DNA is detectable in cell-free blood samples of patients with B-cell neoplasia. Blood 90:4953-4960
15. Rogers A, Joe Y, Manshouri T, Dey A, Jilani I, Giles F, Estey E, Freireich E, Keating M, Kantarjian H, Albitar M (2004) Relative increase in leukemia-specific DNA in peripheral blood plasma from patients with acute myeloid leukemia and myelodysplasia. Blood 103:2799-2801 doi: 10.1182/blood-2003-06-1840
16. Stanulla M, Schrappe M (2009) Treatment of childhood acute lymphoblastic leukemia. Semin Hematol 46:52-63 doi: 10.1053/j.seminhematol.2008.09.007
17. Cario G, Stanulla M, Fine BM, Teuffel O, Neuhoff NV, Schrauder A, Flohr T, Schafer BW, Bartram CR, Welte K, Schlegelberger B, Schrappe M (2005) Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia. Blood 105:821-826 doi: 10.1182/blood-2004-04-1552
18. Cave H, van der Werff ten Bosch J, Suciu S, Guidal C, Waterkeyn C, Otten J, Bakkus M, Thielemans K, Grandchamp B, Vilmer E (1998) Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer - Childhood Leukemia Cooperative Group. N Engl J Med 339:591-598 see comments doi: 10.1056/NEJM199808273390904
19. van Dongen JJM, Seriu T, Panzer-Grumayer ER, Biondi A, Pongers-Willemse MJ, Corral L, Stolz F, Schrappe M, Masera G, Kamps WA, Gadner H, van Wering ER, Ludwig W-D, Basso G, de Bruijn MAC, Cazzaniga G, Hettinger K, van der Does-van den Berg A, Hop WCJ, Riehm H, Bartram CR (1998) Prognostic value of minimal residual disease in childhood acute lymphoblastic leukemia: A prospective study of the International BFM Study Group. Lancet 352:1731-1738 doi: 10.1016/S0140-6736(98)04058-6
20. Flohr T, Schrauder A, Cazzaniga G, Panzer-Grumayer R, van der Velden V, Fischer S, Stanulla M, Basso G, Niggli FK, Schafer BW, Sutton R, Koehler R, Zimmermann M, Valsecchi MG, Gadner H, Masera G, Schrappe M, van Dongen JJ, Biondi A, Bartram CR (2008) Minimal residual disease-directed risk stratification using real-time quantitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements in the international multicenter trial AIEOP-BFM ALL 2000 for childhood acute lymphoblastic leukemia. Leukemia 31:31
21. Lee TH, Montalvo L, Chrebtow V, Busch MP (2001) Quantitation of genomic DNA in plasma and serum samples: Higher concentrations of genomic DNA found in serum than in plasma. Transfusion 41:276-282 doi: 10.1046/ j.1537-2995.2001.41020276.x
22. Anker P, Stroun M, Maurice PA (1975) Spontaneous release of DNA by human blood lymphoctyes as shown in an in vitro system. Cancer Res 35:2375-2382
23. Nakao M, Janssen JW, Flohr T, Bartram CR (2000) Rapid and reliable quantification of minimal residual disease in acute lymphoblastic leukemia using rearranged immunoglobulin and T-cell receptor loci by LightCycler technology. Cancer Res 60:3281-3289
24. van der Velden VH, Hochhaus A, Cazzaniga G, Szczepanski T, Gabert J, van Dongen JJ (2003) Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: Principles, approaches, and laboratory aspects. Leukemia 17:1013-1034 doi: 10.1038/sj.leu.2402922
25. van der Velden VH, Cazzaniga G, Schrauder A, Hancock J, Bader P, Panzer-Grumayer ER, Flohr T, Sutton R, Cave H, Madsen HO, Cayuela JM, Trka J, Eckert C, Foroni L, Zur Stadt U, Beldjord K, Raff T, van der Schoot CE, van Dongen JJ (2007) Analysis of minimal residual disease by Ig/TCR gene rearrangements: Guidelines for interpretation of real-time quantitative PCR data. Leukemia 21:604-611
26. van der Velden VH, Panzer-Grumayer ER, Cazzaniga G, Flohr T, Sutton R, Schrauder A, Basso G, Schrappe M, Wijkhuijs JM, Konrad M, Bartram CR, Masera G, Biondi A, van Dongen JJ (2007) Optimization of PCR-based minimal residual disease diagnostics for childhood acute lymphoblastic leukemia in a multi-center setting. Leukemia 21:706-713
27. Stroun M, Maurice P, Vasioukhin V, Lyautey J, Lederrey C, Lefort F, Rossier A, Chen XQ, Anker P (2000) The origin and mechanism of circulating DNA. Ann N Y Acad Sci 906:161-168
28. Stroun M, Anker P, Maurice P, Lyautey J, Lederrey C, Beljanski M (1989) Neoplastic characteristics of the DNA found in the plasma of cancer patients. Oncology 46:318-322
29. Fournie GJ, Courtin JP, Laval F, Chale JJ, Pourrat JP, Pujazon MC, Lauque D, Carles P (1995) Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumours. Cancer Lett 91:221-227 doi: 10.1016/ 0304-3835(95)03742-F
30. Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD, Knippers R (2001) DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 61:1659-1665
31. Li CN, Hsu HL, Wu TL, Tsao KC, Sun CF, Wu JT (2003) Cell-free DNA is released from tumor cells upon cell death: A study of tissue cultures of tumor cell lines. J Clin Lab Anal 17:103-107 doi: 10.1002/jcla.10081
32. Jachertz D, Anker P, Maurice PA, Stroun M (1979) Information carried by the DNA released by antigen-stimulated lymphocytes. Immunology 37:753-763
33. Stroun M, Lyautey J, Lederrey C, Mulcahy HE, Anker P (2001) Alu repeat sequences are present in increased proportions compared to a unique gene in plasma/serum DNA: Evidence for a preferential release from viable cells? Ann N Y Acad Sci 945:258-264
34. Coustan-Smith E, Sancho J, Hancock ML, Razzouk BI, Ribeiro RC, Rivera GK, Rubnitz JE, Sandlund JT, Pui CH, Campana D (2002) Use of peripheral blood instead of bone marrow to monitor residual disease in children with acute lymphoblastic leukemia. Blood 100:2399-2402 doi: 10.1182/ blood-2002-04-1130
35. van der Velden VH, Jacobs DC, Wijkhuijs AJ, Comans-Bitter WM, Willemse MJ, Hahlen K, Kamps WA, van Wering ER, van Dongen JJ (2002) Minimal residual disease levels in bone marrow and peripheral blood are comparable in children with T cell acute lymphoblastic leukemia (ALL), but not in precursor-B-ALL. Leukemia 16:1432-1436 doi: 10.1038/ sj.leu.2402636